Advances in the Preclinical Study of Some Flavonoids as Potential Antidepressant Agents

Table 1

Plants with antidepressant-like effects associated with their total flavonoids content.

Plant (family)	Doses (animal)	Duration of treatment	Behavioral test	Reference
Alpinia oxyphylla Miq.; (Zingiberaceae)	10 mg/kg,; p.o. (A)	14 days	FST, SPT	[13]
Hemerocallis citrina L.; (Xanthorrhoeaceae)	400 mg/kg,; p.o. (B)	Single dose	TST	[14]
	10, 20, and 40 mg/kg,; p.o. (C)	35 days	SPT	[15]
Apocynum venetum Linn.; (Apocynaceae)	0.35 mM/kg,; i.p. (B)	Single dose	FST, TST	[16]
Hibiscus esculentus L.; (Malvaceae)	500 and 750 mg/kg,; i.p. (D)	Single dose	FST, TST	[17]
Apocynum venetum L.; (Apocynaceae)	50 and 100 mg/kg,; p.o. (E)	10 days	FST, TST	[18]
Glycyrrhiza uralensis Fisch.; (Fabaceae)	30, 100, and 300 mg/kg,; p.o. (F)	28 days	FST, TST	[19, 20]
Byrsonima crassifolia (L.) Kunth; (Malpighiaceae)	500 mg/kg,; p.o. (E)	Single dose	FST	[21]
Cecropia pachystachya Trécul; (Urticaceae)	50 mg/kg,; p.o. (G)	8 days	FST	[22]
Chrysactinia mexicana A. Gray; (Asteraceae)	1, 5, 10, 100, and 200 mg/kg,; p.o. (H)	Single dose	FST	[23]
Opuntia ficus-indica (L.) Mill.; (Cactaceae)	30 mg/kg,; p.o. (E)	14 days	FST, TST	[24]
Hibiscus rosa-sinensis Linn.; (Malvaceae)	30 and 100 mg/kg,; p.o. (C)	Single dose	FST, TST	[25]
Actaea spicata L.; (Ranunculaceae)	200 mg/kg,; p.o. (I)	Single dose	FST	[26]
Clerodendrum serratum Linn.; (Verbenaceae)	25 and 50 mg/kg,; p.o.	7 days	FST, TST	[27]

(A) Male Kunming mice; (B) male mice; (C) male Sprague-Dawley rats; (D) male Swiss albino mice; (E) male ICR mice; (F) rats; (G) male Wistar rats; (H) male Swiss Webster mice; (I) male LACA mice. FST: forced swim test; TST: tail suspension test; SPT: sucrose preference test.