Flavonoid Doses Treatment duration Effects Reference Naringenin 5, 10, and 20 mg/kg 21 days Increase in BDNF concentrations in the hippocampus in male mice [28 ] 5, 10, and 20 mg/kg 14 days Increase in 5-HT, DA, and NE in the hippocampus in male ICR mice [29 ] Luteolin 10 mg/kg 30 min before test Increases in chloride ion flow at the [30 ] 50 mg/kg 23 days Attenuation of the expression of endoplasmic reticulum stress-related proteins in the hippocampus in male ICR mice [31 ] Icariin 60 mg/kg 21 days Increases in BDNF concentrations in the hippocampus in male rats [32 ] Hesperidin 0.01, 0.1, 0.3, and 1 mg/kg 21 days Increase in BDNF concentrations in the hippocampus in male mice [9 ] 50 mg/kg 13 days Increase in BDNF and NGF concentrations in the hippocampus in male C57BL/6 mice [33 ] Astilbin 10, 20, and 40 mg/kg 21 days Increase in BDNF concentrations in the cerebral cortex in male mice, similar to imipramine [34 ] Baicalein 10, 20, and 40 mg/kg 14 days Increase in dopamine and BDNF concentrations in the hippocampus in male rats [35 ] 1 and 4 mg/kg Single injection or 21 days Restoring of the reduction of extracellular signal-regulated kinase phosphorylation and BDNF expression in the hippocampus of male Kunming mice subjected to CUMS [36 ] Chrysin 5 and 20 mg/kg 28 days Increase in BDNF concentrations in the hippocampus and prefrontal cortex in female mice [10 ] 5 and 20 mg/kg 14 days Increase in 5-HT and BDNF concentrations in the hippocampus in male C57B/6J mice [37 ] Fisetin 5, 10, and 20 mg/kg 60 min before test Activation of the serotonergic system, apparently through inactivation of MAO-A enzyme in male mice [38 ] 5 mg/kg 14 days Increases in phosphorylated TrkB (pTrkB) in the hippocampus in male ICR mice [39 ] Orientin 20 and 40 mg/kg 21 days Increase in BDNF, serotonin, and norepinephrine concentrations in the hippocampus and prefrontal cortex in male mice [40 ] 7,8-Dihydroxyflavone 1, 3, and 10 mg/kg 60 min before test Increase in BDNF concentrations in the hippocampus and prefrontal cortex in male mice [41 ] Icariin 20 and 40 mg/kg 35 days Decrease in oxidative stress and neuroinflammation in the hippocampus in male rats [42 ] Dihydromyricetin 10 and 20 mg/kg 7 days Increase in m RNA for BDNF in the hippocampus in male C57BL/6 mice [43 ] Silymarin 100 and 200 mg/kg 14 days Increase in 5-HT, DA, NE, and BDNF concentration in the hippocampus and cerebral cortex, similar to fluoxetine in adult Wistar rats [44 ] Myricitrin 10 mg/kg 21 days Increases in cell proliferation in the subgranular zone of the hippocampal dentate gyrus in male BALB/c mice [45 ] Myricetin 50 mg/kg 21 days Increases in BDNF concentrations in the hippocampus in male C57BL/6 mice [46 ] 50 and 100 mg/kg 15 days Increase in BDNF concentration, neurogenesis, and neuroplasticity in the hippocampus in male C57BL/6 mice [47 , 48 ] Apigenin 20 and 40 mg/kg 21 days Increase in BDNF concentrations in the hippocampus in male ICR mice [49 ] Miquelianin 0.6 mg/kg 14 days Modulation of the hypothalamic-pituitary-adrenal axis by reducing plasma concentration of ACTH and corticosterone in male CD rats [50 ] Isoquercitrin 0.6 mg/kg 14–56 days Modulation of the hypothalamic-pituitary-adrenal axis by reducing plasma concentration of ACTH and corticosterone in male CD rats [50 ] Liquiritin and isoliquiritin 20 mg/kg 30 min before sample Increases in 5-HT and NE concentrations in the hippocampus, hypothalamus, and cortex in mice [51 ]
