Prophylactic Dermatologic Treatment of Afatinib-Induced Skin Toxicities in Patients with Metastatic Lung Cancer: A Pilot Study

Table 1

Skin toxicity grading according to the National Cancer Institute Common Toxicity Criteria for Adverse Events (NCI-CTCAE).

Grade	Description
1	Papules and/or pustules covering <10% BSA, which may or may not be associated with symptoms of pruritus or tenderness
2	Papules and/or pustules covering 10–30% BSA, which may or may not be associated with symptoms of pruritus or tenderness; associated with psychosocial impact; limiting instrumental ADL
3	Papules and/or pustules covering >30% BSA, which may or may not be associated with symptoms of pruritus or tenderness; limiting self-care ADL; associated with local superinfection with oral antibiotics indicated
4	Papules and/or pustules covering any % BSA, which may or may not be associated with symptoms of pruritus or tenderness and are associated with extensive superinfection with IV antibiotics indicated; life-threatening consequences
5	Death

BSA: body surface area; ADL: activities of daily living.