Extensive In Silico Analysis of ATL1 Gene : Discovered Five Mutations That May Cause Hereditary Spastic Paraplegia Type 3A

Figure 10

The conserved amino acids across species in ATL1 protein were determined using ConSurf. e: exposed residues according to the neural-network algorithm are indicated in orange letters. b: residues predicted to be buried are demonstrated via green letters. f: predicted functional residues (highly conserved and exposed) are indicated with red letters. s: predicted structural residues (highly conserved and buried) are demonstrated in blue letters. I: insufficient data (the calculation for this site performed in less than 10% of the sequences) is demonstrated in yellow letters.