Extensive In Silico Analysis of ATL1 Gene : Discovered Five Mutations That May Cause Hereditary Spastic Paraplegia Type 3A

Table 1

Pathogenic nsSNPs predicted by different online tools.

dbSNP rs#	SUB	SIFT prediction	Score	Polyphen prediction	Score	PROVEAN prediction	Score	SNAP2 prediction	Score
rs778130435	F46S	Affect	0	Probably damaging	1	Deleterious	−7.014	Effect	48
rs746927118	V67F	Affect	0	Probably damaging	1	Deleterious	−4.221	Effect	36
rs979765709	T120I	Affect	0	Probably damaging	1	Deleterious	−5.216	Effect	83
rs149031604	T147I	Affect	0	Probably damaging	1	Deleterious	−5.544	Effect	79
rs119476049	R217Q	Affect	0	Probably damaging	1	Deleterious	−3.749	Effect	95
rs1212638776	A359T	Affect	0	Probably damaging	1	Deleterious	−3.722	Effect	20
rs864622269	R495W	Affect	0	Probably damaging	1	Deleterious	−7.265	Effect	73
rs1242753115	G504E	Affect	0	Probably damaging	1	Deleterious	−7.659	Effect	78