Extensive In Silico Analysis of ATL1 Gene : Discovered Five Mutations That May Cause Hereditary Spastic Paraplegia Type 3A

Table 2

The most damaging SNPs predicted by different online tools.

dbSNP rs#	SUB	SNPs&GO prediction	RI	Probability	PHD-SNP prediction	RI	Probability	P-mut prediction	Score
rs746927118	V67F	Disease	1	0.559	Disease	7	0.827	Disease	0.88 (92%)
rs979765709	T120I	Disease	2	0.622	Disease	5	0.765	Disease	0.92 (94%)
rs119476049	R217Q	Disease	3	0.626	Disease	6	0.81	Disease	0.84 (90%)
rs864622269	R495W	Disease	5	0.744	Disease	8	0.921	Disease	0.79 (89%)
rs1242753115	G504E	Disease	1	0.557	Disease	7	0.85	Disease	0.73 (87%)