Extensive In Silico Analysis of ATL1 Gene : Discovered Five Mutations That May Cause Hereditary Spastic Paraplegia Type 3A

Table 3

Protein structural stability calculated using I-Mutant 3.0 and MUPro.

dbSNP rs#	SUB	SVM2 prediction effect	RI	DDG value prediction	MUPro prediction	Score
rs746927118	V67F	Decrease	8	−1.39 kcal/mol	Decrease	−0.88922
rs979765709	T120I	Increase	2	−0.08 kcal/mol	Decrease	−0.39384
rs119476049	R217Q	Decrease	9	−1.09 kcal/mol	Decrease	−0.93524
rs864622269	R495W	Decrease	3	−0.24 kcal/mol	Decrease	−1.07508
rs1242753115	G504E	Decrease	4	0.59 kcal/mol	Decrease	−0.64728