Review Article

The Effects of Exercise on Aging-Induced Exaggerated Cytokine Responses: An Interdisciplinary Discussion

Table 1

Observational studies of the relationship between exercise and inflammatory cytokines in aging.

Age (years)Exercise/physical activityInflammatory markersReferences

74.3 ± 2.7Moderate or strenuous activity (hand-grip strength, chair stands, and gait speed)↓ CRP,
↓ IL-6
D.R. Taaffe et al. 2000 [80]
70–79 years oldRecreational activity, house/yard work activity, work activity, and total physical activity↓ CRP,
↓ IL-6
D. B. Reuben et al. 2003 [81]
40–75 years oldMetabolic equivalent-hours (MET-hours) method↓ sTNF-R1,
↓ sTNF-R2,
↓ IL-6,
↓ CRP
T. Pischon et al. 2003 [82]
70–79 years oldPhysical activity questionnaire (MET-hours/weeks) physical activity from the following categories (housework, stair climbing, walking for exercise, other types of walking, aerobics/calisthenics, weight training, high-intensity exercises, moderate-intensity exercises, or work/volunteer/caregiving activities)↓ CRP,
↓ IL-6,
↓ TNF-α
L. H. Colbert et al. 2004 [83]
48 ± 12Physical activity (MET-hour/weeks)↓ CRP,
↓ WBC count,
↓ TNF-α,
↓ IL-6
C. Pitsavos et al. 2004 [84]
63 ± 10Maximal exercise testing on a motor-driven treadmill or an electrically braked supine bicycle↓ CRPK. Rahimi et al. 2005 [85]
70.3 ± 4.1 69.8 ± 5.5Aerobic exercise treatment (cardio) or a flexibility/strength exercise treatment (flex) 3 days/week, 45 min/day for 10 months↓ IL-18,
↓ IL-6,
↓ CRP
M. L. Kohut et al. 2006 [62]
18–65 years oldPhysical activity test performed on a modified Monark cycle ergometer with 6 min workloads, each separated by a 1 min rest↓ CRP,
↓ TNF-α,
↔ IL-6,
↔ adiponectin
B. J. Arsenault et al. 2009 [86]
76.4 ± 4.1 77.0 ± 4.4Walking for 150 min per week at RPE 12–13 and resistance training at RPE 15-16↓ IL-8,
↔ TNF-α,
↔ sTNFr I,
↔ sTNFr II,
↔ IL-6sR,
↔ IL-1sRII,
↔ IL-1ra
K. M. Beavers et al. 2010 [87]
>50 years old70% of one maximum repetition (1 RM) or less was classified as moderate intensity, while activities requiring over 70% of 1 RM were classified as vigorous intensity↓ CRP,
↓ IL-6,
↔ TNF-α
A. V. Sardeli et al. 2018 [88]

Notes: ↓ refers to significant decreased; ↔ refers to no change. CRP, C-reactive protein (CRP); IL-6, interleukin 6; sTNF-R1, soluble tumor necrosis factor receptor 1; sTNF-R2, soluble tumor necrosis factor receptor 2; TNFα, tumor necrosis factor alpha; WBC count, white blood cell count; IL-18, interleukin 18; sTNFr I, soluble tumor necrosis factor receptor 1; sTNFr II, soluble tumor necrosis factor receptor 2; IL-6sR, soluble interleukin 6 receptor; IL-1sRII, soluble interleukin 1 receptor 2; IL-1ra, interleukin 1 receptor antagonist.