An Investigation into the Use of Stimulant Therapy during Pregnancy

Table 2

Diagnosis, mean sleep latency test (MSLT) results, number of sleep onset REM (SOREM), stimulant therapy, dose, timing of discontinuation of stimulant, medical history, other medications, caffeine use, and smoking status of each patient.

	Diagnosis	MSLT score	SOREM	Medication	Dose	Timing of discontinuation of stimulants	Other medical conditions	Medication other than stimulant	Caffeine use	Smoking status
A	Narcolepsy	Diagnosis made prior to 2000 MSLT result not available		Dexamphetamine	10 mg BD	2004 1st baby: discontinued 8/40; 2009 2nd baby: discontinued 5/40; Continued medication with 2 miscarriages and 1 ectopic	Nil	Nil	Caffeine not used	Smoking status not recorded
B	Idiopathic hypersomnia	4 min	0/4 naps	Dexamphetamine	10 mg BD	Postconceptually but not clear what gestation	Asthma	Seretide, salbutamol, aminophylline montelukast	Caffeine not used	Nonsmoker
C	Idiopathic hypersomnia	2, 4 min	1/5 naps	Modafinil	100 mg BD	Discontinued at 12/40	Obstructive sleep apnoea, Gestational Diabetes	CPAP, metformin	Caffeine use unknown	Nonsmoker
D	Narcolepsy with Cataplexy	Diagnosis made prior to 2000 and referral to this sleep centre		Mazindol	2 mg BD	Continued throughout pregnancy	Hypertension	Fluoxetine, omeprazole, atenolol	Caffeine used	Smoking status not recorded
E	Idiopathic hypersomnia	3, 8 min	1/5 naps	Modafinil	400 mg OD	Stopped modafinil when fell pregnant; started methylphenidate at 17/40	Nil	Nil	Caffeine not used	Smoking status not recorded
F	Hypersomnia	11 min	0/4 naps	Modafinil	100 mgs OD	4 weeks preconception	Costochondritis, asthma	Salbutamol	Caffeine used	Nonsmoker
H	Narcolepsy	Diagnosis make by a private neurologist		Modafinil	200 mg BD	Discontinued 2/40	Eczema	Nil	Caffeine used	Nonsmoker
I	Narcolepsy with Cataplexy	0, 6 min	3/4 naps	Modafinil; citalopram	200 mg BD 20 mgs daily, respectively	Discontinued preconceptually	Previous glandular fever	Nil	Caffeine used	Smoking status not recorded
J	Narcolepsy with Cataplexy	3, 6 min	3/4 naps	Modafinil	100 mg BD	Discontinued at 6/40	Nil	Nil	Caffeine not used	Smoking status not recorded
K	Likely narcolepsy	2, 7 min	1/5 naps	Modafinil	300 mg OD	Discontinued 3 weeks preconception	Nil	Nil	Caffeine use unknown	Ex-smoker
L	Narcolepsy with Cataplexy	2, 3 min	3/4 naps	Methylphenidate	10 mgs BD	Discontinued 6 months perceptually	Nil	Nil	Caffeine used	Nonsmoker
M	Narcolepsy with cataplexy	4, 9 min	3/4 naps	Dexamphetamine	5 mgs BD	Discontinued 7/40	Simple solar lentigos on upper back	Nil	Caffeine used	Smoking status not recorded
N	Narcolepsy with cataplexy	Diagnosis made by paediatric neurologist: notes unavailable		Methylphenidate	36 mg OD	Continued throughout pregnancy	Nil	Nil	Caffeine use unknown	Smoking status not recorded
O	Narcolepsy	1, 6 min	3/4 naps	Modafinil and venlafaxine	200 mgs daily	Discontinued 4 weeks preconceptually	Polycystic ovaries, eczema	nil	Caffeine not used	Nonsmoker
P	Narcolepsy	0 h 7 m 0 s	2/4 naps	Modafinil	100 mgs BD	Discontinued 2 weeks preconceptually	Nil	nil	Caffeine use unknown	Nonsmoker