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Sleep Disorders
Volume 2012, Article ID 634920, 9 pages
http://dx.doi.org/10.1155/2012/634920
Research Article

Association of Plasma Homocysteine with Self-Reported Sleep Apnea Is Confounded by Age: Results from the National Health and Nutrition Examination Survey 2005-2006

1Lata Medical Research Foundation, Nagpur, 440022, India
2Cleveland Clinic Sleep Disorders Center, Cleveland, OH 44195, USA
3Advanced Education in General Dentistry program, Case School of Dental Medicine, Cleveland, OH 44206, USA
4Texas Biomedical Research Institute, San Antonio, TX 78227-5301, USA

Received 15 October 2011; Revised 10 November 2011; Accepted 14 November 2011

Academic Editor: Sophia Schiza

Copyright © 2012 Tushar P. Thakre et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. G. Park, K. Ramar, and E. J. Olson, “Updates on definition, consequences, and management of obstructive sleep apnea concise review for clinicians,” Mayo Clinic Proceedings, vol. 86, no. 6, pp. 549–555, 2011. View at Publisher · View at Google Scholar
  2. L. Ye, G. W. Pien, and T. E. Weaver, “Gender differences in the clinical manifestation of obstructive sleep apnea,” Sleep Medicine, vol. 10, no. 10, pp. 1075–1084, 2009. View at Publisher · View at Google Scholar · View at Scopus
  3. K. Chilukuri, D. Dalal, S. Gadrey et al., “A prospective study evaluating the role of obesity and obstructive sleep apnea for outcomes after catheter ablation of atrial fibrillation,” Journal of Cardiovascular Electrophysiology, vol. 21, no. 5, pp. 521–525, 2010. View at Publisher · View at Google Scholar · View at Scopus
  4. P. S. Yeh, Y. C. Lee, W. J. Lee et al., “Clinical predictors of obstructive sleep apnea in Asian bariatric patients,” Obesity Surgery, vol. 20, no. 1, pp. 30–35, 2010. View at Publisher · View at Google Scholar · View at Scopus
  5. F. H. S. Kuniyoshi, S. Pusalavidyasagar, P. Singh, and V. K. Somers, “Cardiovascular consequences of obstructive sleep apnoea,” Indian Journal of Medical Research, vol. 131, no. 2, pp. 196–205, 2010. View at Google Scholar · View at Scopus
  6. W. K. Al-Delaimy, J. E. Manson, W. C. Willett, M. J. Stampfer, and F. B. Hu, “Snoring as a risk factor for type II diabetes mellitus: a prospective study,” American Journal of Epidemiology, vol. 155, no. 5, pp. 387–393, 2002. View at Publisher · View at Google Scholar · View at Scopus
  7. P. A. Lanfranchi and V. K. Somers, “Sleep-disordered breathing in heart failure: characteristics and implications,” Respiratory Physiology and Neurobiology, vol. 136, no. 2-3, pp. 153–165, 2003. View at Publisher · View at Google Scholar
  8. A. Iranzo, J. Santamaría, J. Berenguer, M. Sánchez, and A. Chamorro, “Prevalence and clinical importance of sleep apnea in the first night after cerebral infarction,” Neurology, vol. 58, no. 6, pp. 911–916, 2002. View at Google Scholar · View at Scopus
  9. M. Winnicki and P. Palatini, “Obstructive sleep apnoea and plasma homocysteine: an overview,” European Heart Journal, vol. 25, no. 15, pp. 1281–1283, 2004. View at Publisher · View at Google Scholar · View at Scopus
  10. B. G. Phillips and V. K. Somers, “Sleep disordered breathing and risk factors for cardiovascular disease,” Current Opinion in Pulmonary Medicine, vol. 8, no. 6, pp. 516–520, 2002. View at Publisher · View at Google Scholar · View at Scopus
  11. S. Bananian, S. G. Lehrman, and G. P. Maguire, “Cardiovascular consequences of sleep-related breathing disorders,” Heart Disease, vol. 4, no. 5, pp. 296–305, 2002. View at Google Scholar · View at Scopus
  12. R. Ientile, M. Curro', N. Ferlazzo, S. Condello, D. Caccamo, and F. Pisani, “Homocysteine, vitamin determinants and neurological diseases,” Frontiers in Bioscience, vol. 2, pp. 359–372, 2010. View at Google Scholar
  13. O. Stanger, W. Herrmann, K. Pietrzik et al., “DACH-LIGA homocystein (German, Austrian and Swiss homocysteine society): consensus paper on the rational clinical use of homocysteine, folic acid and B-vitamins in cardiovascular and thrombotic diseases: guidelines and recommendations,” Clinical Chemistry and Laboratory Medicine, vol. 41, no. 11, pp. 1392–1403, 2003. View at Publisher · View at Google Scholar · View at Scopus
  14. O. K. Basoglu, F. Sarac, S. Sarac, H. Uluer, and C. Yilmaz, “Metabolic syndrome, insulin resistance, fibrinogen, homocysteine, leptin, and C-reactive protein in obese patients with obstructive sleep apnea syndrome,” Annals of Thoracic Medicine, vol. 6, no. 3, pp. 120–125, 2011. View at Publisher · View at Google Scholar
  15. M. Can, S. Açikgöz, G. Mungan et al., “Serum cardiovascular risk factors in obstructive sleep apnea,” Chest, vol. 129, no. 2, pp. 233–237, 2006. View at Publisher · View at Google Scholar · View at Scopus
  16. R. M. Cerbo, R. Cabano, G. Lombardi, L. Bollani, R. Colombo, and M. Stronati, “From apneic spells to the development of hypertensive hydrocephalus: a case report of homocystinuria with early onset,” Journal of Child Neurology, vol. 25, no. 3, pp. 368–370, 2010. View at Publisher · View at Google Scholar · View at Scopus
  17. M. Chen, B. Wu, X. Ye et al., “Association between plasma homocysteine levels and obstructive sleep apnoea in patients with ischaemic stroke,” Journal of Clinical Neuroscience, vol. 18, no. 11, pp. 1454–1457, 2011. View at Publisher · View at Google Scholar
  18. F. Cintra, S. Tufik, V. D'Almeida et al., “Cysteine: a potential biomarker for obstructive sleep apnea,” Chest, vol. 139, no. 2, pp. 246–252, 2011. View at Publisher · View at Google Scholar
  19. H. Hachul De Campos, L. Brandão, V. D'Almeida et al., “Sleep disturbances, oxidative stress and cardiovascular risk parameters in postmenopausal women complaining of insomnia,” Climacteric, vol. 9, no. 4, pp. 312–319, 2006. View at Publisher · View at Google Scholar · View at Scopus
  20. O. Kokturk, T. U. Ciftci, E. Mollarecep, and B. Ciftci, “Serum homocysteine levels and cardiovascular morbidity in obstructive sleep apnea syndrome,” Respiratory Medicine, vol. 100, no. 3, pp. 536–541, 2006. View at Publisher · View at Google Scholar · View at Scopus
  21. M. Kumor, R. Rubinsztajn, K. Byśkiniewicz, P. Bielicki, and R. Chazan, “Serum concentration of homocysteine and the risk of atherosclerosis in patients with obstructive sleep apnea syndrome,” Pneumonologia i Alergologia Polska, vol. 74, no. 1, pp. 117–121, 2006. View at Google Scholar · View at Scopus
  22. L. Lavie, A. Perelman, and P. Lavie, “Plasma homocysteine levels in obstructive sleep apnea: association with cardiovascular morbidity,” Chest, vol. 120, no. 3, pp. 900–908, 2001. View at Publisher · View at Google Scholar · View at Scopus
  23. Y. Ozkan, H. Firat, B. Şimşek, M. Torun, and S. Yardim-Akaydin, “Circulating nitric oxide (NO), asymmetric dimethylarginine (ADMA), homocysteine, and oxidative status in obstructive sleep apnea-hypopnea syndrome (OSAHS),” Sleep and Breathing, vol. 12, no. 2, pp. 149–154, 2008. View at Publisher · View at Google Scholar · View at Scopus
  24. S. Ryan, G. M. Nolan, E. Hannigan, S. Cunningham, C. Taylor, and W. T. McNicholas, “Cardiovascular risk markers in obstructive sleep apnoea syndrome and correlation with obesity,” Thorax, vol. 62, no. 6, pp. 509–514, 2007. View at Publisher · View at Google Scholar · View at Scopus
  25. N. Sariman, E. Levent, F. B. Aksungar, A. C. Soylu, and O. Bektaş, “Homocysteine levels and echocardiographic findings in obstructive sleep apnea syndrome,” Respiration, vol. 79, no. 1, pp. 38–45, 2009. View at Publisher · View at Google Scholar · View at Scopus
  26. A. Svatikova, R. Wolk, M. J. Magera, A. S. Shamsuzzaman, B. G. Phillips, and V. K. Somers, “Plasma homocysteine in obstructive sleep apnoea,” European Heart Journal, vol. 25, no. 15, pp. 1325–1329, 2004. View at Publisher · View at Google Scholar · View at Scopus
  27. L. Wang, J. Li, Y. Xie, and X. G. Zhang, “Association between serum homocysteine and oxidative stress in elderly patients with obstructive sleep apnea/hypopnea syndrome,” Biomedical and Environmental Sciences, vol. 23, no. 1, pp. 42–47, 2010. View at Publisher · View at Google Scholar · View at Scopus
  28. Z. Yavuz, A. Ursavaş, E. Ege et al., “Homocysteine levels in patients with obstructive sleep apnea syndrome,” Tüberküloz ve Toraks, vol. 56, no. 1, pp. 37–42, 2008. View at Google Scholar · View at Scopus
  29. J. L. Shih and A. Malhotra, “Could vitamins be helpful to patients with sleep apnea?” Chest, vol. 139, no. 2, pp. 237–238, 2011. View at Publisher · View at Google Scholar
  30. C. Li, E. S. Ford, G. Zhao, J. B. Croft, L. S. Balluz, and A. H. Mokdad, “Prevalence of self-reported clinically diagnosed sleep apnea according to obesity status in men and women: National Health and Nutrition Examination Survey, 2005-2006,” Preventive Medicine, vol. 51, no. 1, pp. 18–23, 2010. View at Publisher · View at Google Scholar · View at Scopus
  31. M. M. Budge, C. De Jager, E. Hogervorst, and A. D. Smith, “Total plasma homocysteine, age, systolic blood pressure, and cognitive performance in older people,” Journal of the American Geriatrics Society, vol. 50, no. 12, pp. 2014–2018, 2002. View at Publisher · View at Google Scholar · View at Scopus
  32. M. El-Sammak et al., “Elevated plasma homocysteine is positively associated with age independent of C677T mutation of the methylenetetrahydrofolate reductase gene in selected Egyptian subjects,” International Journal of Medical Sciences, vol. 1, no. 3, pp. 181–192, 2004. View at Google Scholar
  33. L. Norlund, A. Grubb, G. Fex et al., “The increase of plasma homocysteine concentrations with age is partly due to the deterioration of renal function as determined by plasma cystatin C,” Clinical Chemistry and Laboratory Medicine, vol. 36, no. 3, pp. 175–178, 1998. View at Publisher · View at Google Scholar · View at Scopus
  34. L. D. Spotila, P. F. Jacques, P. B. Berger, K. V. Ballman, R. C. Ellison, and R. Rozen, “Age dependence of the influence of methylenetetrahydrofolate reductase genotype on plasma homocysteine level,” American Journal of Epidemiology, vol. 158, no. 9, pp. 871–877, 2003. View at Publisher · View at Google Scholar · View at Scopus
  35. L. Lavie, P. Lavie, A. Svatikova et al., “Obstructive sleep apnoea and plasma homocysteine,” European Heart Journal, vol. 26, no. 20, pp. 2210–2211, 2005. View at Publisher · View at Google Scholar · View at Scopus
  36. M. Galloway and L. Rushworth, “Red cell or serum folate? Results from the National Pathology Alliance benchmarking review,” Journal of Clinical Pathology, vol. 56, no. 12, pp. 924–926, 2003. View at Publisher · View at Google Scholar · View at Scopus