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Sleep Disorders
Volume 2014, Article ID 518920, 6 pages
Clinical Study

Relationships between Obstructive Sleep Apnea Syndrome, Continuous Positive Airway Pressure Treatment, and Inflammatory Cytokines

1Department of Chest Diseases, Seydişehir State Hospital, 42370 Konya, Turkey
2Department of Chest Diseases, Meram Medical Faculty, Necmettin Erbakan University, 42090 Konya, Turkey
3Department of Chest Diseases, Fatih Sultan Mehmet Education and Research Hospital, 34726 Istanbul, Turkey
4Department of Biochemistry, Konya Education and Research Hospital, 42090 Konya, Turkey

Received 2 February 2014; Accepted 23 March 2014; Published 6 May 2014

Academic Editor: Marco Zucconi

Copyright © 2014 Filiz Ünüvar Doğan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The cardiovascular complications that frequently accompany obstructive sleep apnea syndrome (OSAS) are thought to develop as a result of inflammatory stress associated with cytokines such as IL-6 and TNF-α. We conducted the current study to compare levels of these cytokines in OSAS patients and nonapneic controls . Furthermore, we investigated the impact of a three-month regime of continuous positive airway pressure (CPAP) on serum levels of IL-6 and TNF-α only in the OSAS patients. There were no significant differences in serum levels of either IL-6 () or TNF- α () or TNF-α () between OSAS patients and nonapneic controls. Serum IL-6 levels correlated significantly with neck circumference in OSAS patients (). In OSAS patients, reduced levels of TNF-α and IL-6 correlated with increases in mean SaO2 after CPAP treatment ( and , resp.). However, neither of cytokine levels was significantly impacted by CPAP therapy (both ). We have demonstrated that plasma cytokine levels are similar in both otherwise healthy subjects with OSAS and in nonapneic control, and we conclude that OSAS-related parameters and CPAP treatment do not play a significant role in altering cytokine levels.