System Device type Database /ratio maleAge (mean ± std.) AHI (mean ± std.) Reference test Event definition Lab/home Cut-off AHI Sensitivity (%) Specificity (%) Others Study source Morpheus I I Brigham and Women’s Hospital, USA 31/0.71 44.3 ± 11.3 20.6 ± 23 (scorer 1) 22.5 ± 24.5 (scorer 2) Same-night Level 1 PSG H: >30% reduction + 4% desaturation L 15 — — AUC = 0.98 Pittman et al. [105 ] Somnolyzer 24x7 I SIESTA database [106 ] 51/0.86 51 ± 10 45 ± 31 Same-night Level 1 PSG — L — — — Woertz et al. [107 ] -Somnostar 4100I Hospital Mutua de Terrassa, Spain 28/0.75 50 ± 8.8 — Same-night Level 1 PSG H: significant reduction + [3% desaturation or arousal] L 10 55 100 ICC = 0.81 Barreiro et al. [108 ] Morpheus Hx III Brigham and Women’s Hospital, USA 53/0.68 47.8 ± 11.3 15.4 ± 24 Same-night Level 1 PSG AASM2007 L 15 100 92.7 Amir et al. [109 ] ARES III Murrieta Sleep Medical Center and Pomona Valley Hospital, USA 284/0.62 48 — Same-night Level 1 PSG — L 10 97.4 85.6 = 0.85Westbrook et al. [110 ] 187/0.66 46 — Different-night Level 1 PSG — H 30 79.4 100 = 0.77Westbrook et al. [110 ] NYU Sleep Disorders Center, USA 92/— — — Same-night Level 1 PSG H: >50% reduction or discernible reduction + 4% desaturation L 15 951 941 — Ayappa et al. [111 ] 86/— — — Different-night Level 1 PSG H: >50% reduction or discernible reduction + 4% desaturation H 15 851 911 — Ayappa et al. [111 ] Prince of Wales Hospital, The Chinese University of Hong Kong, China 132/0.75 47.8 ± 9.8 (men) 52.3 ± 12.2 (women) 41.6 ± 26.9 (men) 32.3 ± 22.9 (women) Same-night Level 1 PSG AASM1999 H: >50% reduction or discernible reduction + [3% desaturation or arousal] L 5 89 100 AUC = 0.97 To et al. [112 ] Somnocheck III University of Erlangen-Nuremberg, Germany 51/0.86 53.4 ± 12.9 23.9 ± 26.2 Same-night Level 1 PSG H: >50% reduction + 4% desaturation L 10 83 95 = 0.83Ficker et al. [113 ] WristOx 3100 IV Hospital Aleman, Argentina 154/0.77 50.8 ± 14.3 13.8 Same-night Level 1 PSG H: discernible reduction + [3% desaturation or arousal] L 5 89.2 94.2 AUC = 0.96 Nigro et al. [114 ] WatchPAT 100 IV Brigham and Women’s Hospital, USA 30/0.63 47 ± 14.8 23 ± 23.9 Same-night Level 1 PSG AASM1999 H: >50% reduction or discernible reduction + [3% desaturation or arousal] L 20 90.9 84.2 = 0.87Ayas et al. [115 ] Technion Sleep Medicine Center, Israel 102/0.76 41.4 ± 15.2 — Same-night Level 1 PSG AASM1999 H: >50% reduction or discernible reduction + [3% desaturation or arousal] L 20 — — = 0.88 AUC = 0.87Bar et al. [116 ] Brigham and Women’s Hospital, USA 29/0.72 43.2 ± 10.8 31.6 ± 20.6 Same-night Level 1 PSG AASM1999 H: >50% reduction or discernible reduction + [3% desaturation or arousal] L 10 96 100 = 0.89 ICC = 0.88 AUC = 0.96Pittman et al. [117 ] Different-night Level 1 PSG AASM1999 H: >50% reduction or discernible reduction + [3% desaturation or arousal] H 15 96 100 r = 0.72 ICC = 0.72 AUC = 0.97Pittman et al. [117 ] Skaraborg Sleep Study [118 ], Sweden 98/0.56 60 ± 6.7 25.5 ± 22.9 Same-night Level 2 PSG H: >50% reduction or discernible reduction + [4% desaturation or arousal] H 10 — — r = 0.90 AUC = 0.93Zou et al. [119 ] ApneaLink IV Prince of Wales Hospital, The Chinese University of Hong Kong, China 50/0.88 50 ± 11.8 — Same-night Level 1 PSG AASM1999 H: >50% reduction or discernible reduction + [3% desaturation or arousal] L 5 1001 1001 AUC2 = 1.00 Ng et al. [120 ] — 59/0.49 57.3 ± 12 — Same-night Level 1 PSG AASM1999 L 15 90.9 94.6 AUC = 0.97 Erman et al. [121 ] Sleep Disorders Center, King Saud University, Saudi Arabia 95/0.61 46.3 ± 12.6 34.1 ± 32.4 Same-night Level 1 PSG AASM2007 H: >50% reduction + [3% desaturation or arousal] L 30 63 98 r = 0.88 AUC = 0.88Bahammam et al. [122 ] Hospital Aleman, Argentina 90/0.77 49.6 ± 15.1 — Same-night Level 1 PSG H: >50% reduction L 30 88.5 95.3 ICC = 0.88 r = 0.89 AUC = 0.92 Nigro et al. [123 ] The University of British Columbia Hospital, Canada 50/0.64 48.7 ± 12.6 30 ± 25.8 Same-night Level 1 PSG AASM1999 L 10 95 90 AUC = 0.98 ICC = 0.96 Chen et al. [124 ] — 102/0.76 54.7 ± 13.3 — Same-night Level 1 PSG AASM1999 L 15 92 88.5 r = 0.95Ragette et al. [125 ] 131/0.72 59.1 ± 14.6 — Different-night Level 1 PSG AASM1999 H 5 91.8 76.5 r = 0.85Ragette et al. [125 ] Somnolter III — 90/0.67 55.4 ± 8.7 — Same-night Level 1 PSG H: >50% reduction or >30% reduction + [3% desaturation or arousal] L — 83.6 81.8 r = 0.95Cheliout-Heraut et al. [126 ] Embletta III Sleep Center, Royal Infirmary NHS Trust, Scotland, UK 39/0.82 46 ± 9 35.4 ± 5.5 Same-night Level 1 PSG H: >50% reduction (on nasal pressure) L — — — = 0.28Dingli et al. [127 ] 50/— 50 ± 11 29.2 ± 2.7 Different-night Level 1 PSG H: >50% reduction (on thoracoabdominal movement) H — — — = 0.1Dingli et al. [127 ] Embletta PDS III Prince of Wales Hospital, China 80/0.78 51.4 ± 11.9 21.6 ± 19.1 Same-night Level 1 PSG H: >30% reduction + [4% desaturation or arousal] L 15 88 95 = 0.98Ng et al. [128 ] Lifeshirt III — 48/0.72 44 19.3 ± 24.6 Same-night Level 1 PSG H: >30% reduction + [3% desaturation or arousal] L 25 1001 971 AUC2 = 0.99 Goodrich and Orr [129 ] Dallas Veterans Affairs Medical Center, USA 10/0.8 48.8 ± 14.2 28.2 ± 21.1 Same-night Level 1 PSG H: >25% reduction + 3% desaturation L 5 100 50 = 0.82Carter et al. [130 ] Different-night Level 1 PSG H: >25% reduction + 3% desaturation H 5 100 100 = 0.96Carter et al. [130 ] BreasSC20 III Hospital Virgen de la Arrixaca, Spain 48/— — 28.2 Same-night Level 3 PG H: >30% reduction + 4% desaturation H 5 — — = 0.72Ruiz-López et al. [131 ] Hospital Txagorritxu de Victoria-Gasteiz, Spain 60/0.77 51.6 ± 13.2 31 ± 27.6 Same-night Level 1 PSG H: >50% reduction + [3% desaturation or arousal] L 20 93.5 96.6 = 0.90 AUC = 0.98Núñez et al. [132 ] RUSleeping RTS IV Greater Pittsburgh Clinical Sleep Laboratory, USA 25/0.36 42.4 ± 12.9 20.6 ± 26.8 Same-night Level 1 PSG AASM1999 L 5 83 100 = 0.73 AUC = 0.94Grover and Pittman [133 ] Stardust II III — 62/0.67 45.6 ± 18.2 25.3 ± 21.4 Same-night Level 3 PG AASM1999 H: >50% reduction or discernible reduction + [3% desaturation or arousal] H 50 100 92.5 = 0.33 = 0.95Yin et al. [134 ]