Table of Contents Author Guidelines Submit a Manuscript
Sleep Disorders
Volume 2016, Article ID 8032528, 7 pages
http://dx.doi.org/10.1155/2016/8032528
Research Article

Characteristics and Trends in Hypnotics Consumption in the Largest Health Care System in Israel

1Sleep Clinic, Clalit Health Services, Technion Faculty of Medicine, Haifa, Israel
2Department of Community Medicine and Epidemiology, Carmel Medical Center and Technion Faculty of Medicine, Haifa, Israel
3Office of Chief Physician, Clalit Health Services, Tel Aviv, Israel

Received 4 June 2016; Accepted 9 August 2016

Academic Editor: Michel M. Billiard

Copyright © 2016 O. Marom et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. H. Silber, “Clinical practice. Chronic insomnia,” The New England Journal of Medicine, vol. 353, no. 8, pp. 803–810, 2005. View at Publisher · View at Google Scholar
  2. E. Mai and D. J. Buysse, “Insomnia: prevalence, impact, pathogenesis, differential diagnosis, and evaluation,” Sleep Medicine Clinics, vol. 3, no. 2, pp. 167–174, 2008. View at Publisher · View at Google Scholar · View at Scopus
  3. D. N. Neubauer, “The evolution and development of insomnia pharmacotherapies,” Journal of Clinical Sleep Medicine, vol. 3, no. 5, pp. S11–S15, 2007. View at Google Scholar · View at Scopus
  4. N. D. Dautovich, J. McNamara, J. M. Williams, N. J. Cross, and C. S. McCrae, “Tackling sleeplessness: psychological treatment options for insomnia,” Nature and Science of Sleep, vol. 2, pp. 23–37, 2010. View at Google Scholar · View at Scopus
  5. M. M. Ohayon, “Nocturnal awakenings and difficulty resuming sleep: their burden in the European general population,” Journal of Psychosomatic Research, vol. 69, no. 6, pp. 565–571, 2010. View at Publisher · View at Google Scholar · View at Scopus
  6. M. M. Ohayon and T. Sagales, “Prevalence of insomnia and sleep characteristics in the general population of Spain,” Sleep Medicine, vol. 11, no. 10, pp. 1010–1018, 2010. View at Publisher · View at Google Scholar · View at Scopus
  7. S. J. Wilson, D. J. Nutt, C. Alford et al., “British Association for Psychopharmacology consensus statement on evidence-based treatment of insomnia, parasomnias and circadian rhythm disorders,” Journal of Psychopharmacology, vol. 24, no. 11, pp. 1577–1601, 2010. View at Publisher · View at Google Scholar · View at Scopus
  8. T. Unbehaun, K. Spiegelhalder, V. Hirscher, and D. Riemann, “Management of insomnia: update and new approaches,” Nature and Science of Sleep, vol. 2, pp. 127–138, 2010. View at Google Scholar · View at Scopus
  9. A. N. Vgontzas, D. Liao, E. O. Bixler, G. P. Chrousos, and A. Vela-Bueno, “Insomnia with objective short sleep duration is associated with a high risk for hypertension,” SLEEP, vol. 32, no. 4, pp. 491–497, 2009. View at Google Scholar · View at Scopus
  10. J. Fernandez-Mendoza, A. N. Vgontzas, D. Liao et al., “Insomnia with objective short sleep duration and incident hypertension: the Penn State Cohort,” Hypertension, vol. 60, no. 4, pp. 929–935, 2012. View at Publisher · View at Google Scholar · View at Scopus
  11. L. E. Laugsand, L. J. Vatten, C. Platou, and I. Janszky, “Insomnia and the risk of acute myocardial infarction: a population study,” Circulation, vol. 124, no. 19, pp. 2073–2081, 2011. View at Publisher · View at Google Scholar · View at Scopus
  12. Y. Kachi, M. Nakao, T. Takeuchi, and E. Yano, “Association between insomnia symptoms and hemoglobin A1c level in Japanese men,” PLoS ONE, vol. 6, no. 7, Article ID e21420, 2011. View at Publisher · View at Google Scholar · View at Scopus
  13. R. Budhiraja, T. Roth, D. W. Hudgel, P. Budhiraja, and C. L. Drake, “Prevalence and polysomnographic correlates of insomnia comorbid with medical disorders,” SLEEP, vol. 34, no. 7, pp. 859–867, 2011. View at Publisher · View at Google Scholar · View at Scopus
  14. M. Novak, I. Mucsi, C. M. Shapiro, J. Rethelyi, and M. S. Kopp, “Increased utilization of health services by insomniacs—an epidemiological perspective,” Journal of Psychosomatic Research, vol. 56, no. 5, pp. 527–536, 2004. View at Publisher · View at Google Scholar · View at Scopus
  15. D. Garfinkel, M. Zorin, J. Wainstein, Z. Matas, M. Laudon, and N. Zisapel, “Efficacy and safety of prolonged-release melatonin in insomnia patients with diabetes: a randomized, double-blind, crossover study,” Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, vol. 4, pp. 307–313, 2011. View at Google Scholar
  16. A. D. Krystal, M. Erman, G. K. Zammit, C. Soubrane, and T. Roth, “Long-term efficacy and safety of zolpidem extended-release 12.5 mg, administered 3 to 7 nights per week for 24 weeks, in patients with chronic primary insomnia: a 6-month, randomized, double-blind, placebo-controlled, parallel-group, multicenter study,” SLEEP, vol. 31, no. 1, pp. 79–90, 2008. View at Google Scholar · View at Scopus
  17. B. A. Kleykamp, R. R. Griffiths, U. D. McCann, M. T. Smith, and M. Z. Mintzer, “Acute effects of zolpidem extended-release on cognitive performance and sleep in healthy males after repeated nightly use,” Experimental and Clinical Psychopharmacology, vol. 20, no. 1, pp. 28–39, 2012. View at Publisher · View at Google Scholar · View at Scopus
  18. D. F. Kripke, M. R. Klauber, D. L. Wingard, R. L. Fell, J. D. Assmus, and L. Garfinkel, “Mortality hazard associated with prescription hypnotics,” Biological Psychiatry, vol. 43, no. 9, pp. 687–693, 1998. View at Publisher · View at Google Scholar · View at Scopus
  19. G. Belleville, “Mortality hazard associated with anxiolytic and hypnotic drug use in the National Population Health Survey,” Canadian Journal of Psychiatry, vol. 55, no. 9, pp. 558–567, 2010. View at Google Scholar · View at Scopus
  20. N. T. Vozoris and R. S. Leung, “Sedative medication use: prevalence, risk factors, and associations with body mass index using population-level data,” Sleep, vol. 34, no. 7, pp. 869–874, 2011. View at Publisher · View at Google Scholar · View at Scopus
  21. S. M. Bertisch, S. J. Herzig, J. W. Winkelman, and C. Buettner, “National use of prescription medications for insomnia: NHANES 1999–2010,” SLEEP, vol. 37, no. 2, pp. 343–349, 2014. View at Publisher · View at Google Scholar · View at Scopus
  22. A. Tarasiuk, G. Reznor, S. Greenberg-Dotan, and H. Reuveni, “Financial incentive increases CPAP acceptance in patients from low socioeconomic background,” PLoS ONE, vol. 7, no. 3, Article ID e33178, 2012. View at Publisher · View at Google Scholar · View at Scopus
  23. T. Simon-Tuval, S. M. Scharf, N. Maimon, B. J. Bernhard-Scharf, H. Reuveni, and A. Tarasiuk, “Determinants of elevated healthcare utilization in patients with COPD,” Respiratory Research, vol. 12, article 7, 2011. View at Publisher · View at Google Scholar · View at Scopus
  24. T. Simon-Tuval, H. Reuveni, S. Greenberg-Dotan, A. Oksenberg, A. Tal, and A. Tarasiuk, “Low socioeconomic status is a risk factor for CPAP acceptance among adult OSAS patients requiring treatment,” Sleep, vol. 32, no. 4, pp. 545–552, 2009. View at Google Scholar · View at Scopus
  25. A. Safadi, T. Etzioni, D. Fliss, G. Pillar, and C. Shapira, “The effect of the transition to home monitoring for the diagnosis of OSAS on test availability, waiting time, patients' satisfaction, and outcome in a large health provider system,” Sleep Disorders, vol. 2014, Article ID 418246, 6 pages, 2014. View at Publisher · View at Google Scholar
  26. W. Saliba and G. Rennert, “CHA2DS2-VASc score is directly associated with the risk of pulmonary embolism in patients with atrial fibrillation,” The American Journal of Medicine, vol. 127, no. 1, pp. 45–52, 2014. View at Publisher · View at Google Scholar · View at Scopus
  27. E. Hering, I. Pritsker, L. Gonchar, and G. Pillar, “Obesity in children is associated with increased health care use,” Clinical Pediatrics, vol. 48, no. 8, pp. 812–818, 2009. View at Publisher · View at Google Scholar · View at Scopus
  28. J. M. Y. Cheung, D. J. Bartlett, C. L. Armour, N. Glozier, and B. Saini, “Insomnia patients' help-seeking experiences,” Behavioral Sleep Medicine, vol. 12, no. 2, pp. 106–122, 2014. View at Publisher · View at Google Scholar · View at Scopus
  29. R. Paulose-Ram, B. S. Jonas, D. Orwig, and M. A. Safran, “Prescription psychotropic medication use among the U.S. adult population: results from the third National Health and Nutrition Examination Survey, 1988–1994,” Journal of Clinical Epidemiology, vol. 57, no. 3, pp. 309–317, 2004. View at Publisher · View at Google Scholar · View at Scopus
  30. M. Calem, J. Bisla, A. Begum et al., “Increased prevalence of insomnia and changes in hypnotics use in England over 15 years: analysis of the 1993, 2000, and 2007 National Psychiatric Morbidity Surveys,” Sleep, vol. 35, no. 3, pp. 377–384, 2012. View at Publisher · View at Google Scholar · View at Scopus
  31. C. I. Neutel and S. B. Patten, “Sleep medication use in Canadian seniors,” Canadian Journal of Clinical Pharmacology, vol. 16, no. 3, pp. e443–e452, 2009. View at Google Scholar · View at Scopus
  32. P.-L. Chen, W.-J. Lee, W.-Z. Sun, Y.-J. Oyang, and J.-L. Fuh, “Risk of dementia in patients with insomnia and long-term use of hypnotics: a population-based retrospective cohort study,” PLoS ONE, vol. 7, no. 11, Article ID e49113, 2012. View at Publisher · View at Google Scholar · View at Scopus
  33. D.-Y. Kang, S. Park, C.-W. Rhee et al., “Zolpidem use and risk of fracture in elderly insomnia patients,” Journal of Preventive Medicine and Public Health, vol. 45, no. 4, pp. 219–226, 2012. View at Publisher · View at Google Scholar · View at Scopus
  34. S. Ram, H. Seirawan, S. K. S. Kumar, and G. T. Clark, “Prevalence and impact of sleep disorders and sleep habits in the United States,” Sleep and Breathing, vol. 14, no. 1, pp. 63–70, 2010. View at Publisher · View at Google Scholar · View at Scopus
  35. D. J. Bartlett, N. S. Marshall, A. Williams, and R. R. Grunstein, “Predictors of primary medical care consultation for sleep disorders,” Sleep Medicine, vol. 9, no. 8, pp. 857–864, 2008. View at Publisher · View at Google Scholar · View at Scopus
  36. F. Hoffmann, “Perceptions of German GPs on benefits and risks of benzodiazepines and Z-drugs,” Swiss Medical Weekly, vol. 143, Article ID w13745, 2013. View at Publisher · View at Google Scholar
  37. G. Rennert and Y. Peterburg, “Prevalence of selected chronic diseases in Israel,” The Israel Medical Association Journal, vol. 3, no. 6, pp. 404–408, 2001. View at Google Scholar
  38. E. Robinson, J. Mohilever, J. Zidan, and D. Sapir, “Colorectal cancer: incidence, delay in diagnosis and stage of disease,” European Journal of Cancer and Clinical Oncology, vol. 22, no. 2, pp. 157–161, 1986. View at Publisher · View at Google Scholar · View at Scopus
  39. P. Voyer, M. Préville, D. Cohen, D. Berbiche, and S.-G. Béland, “The prevalence of benzodiazepine dependence among community-dwelling older adult users in Quebec according to typical and atypical criteria,” Canadian Journal on Aging, vol. 29, no. 2, pp. 205–213, 2010. View at Publisher · View at Google Scholar · View at Scopus
  40. M. Ben-Hamou, N. S. Marshall, R. R. Grunstein, B. Saini, and R. A. Fois, “Spontaneous adverse event reports associated with zolpidem in Australia 2001–2008,” Journal of Sleep Research, vol. 20, no. 4, pp. 559–568, 2011. View at Publisher · View at Google Scholar · View at Scopus
  41. S. Omvik, S. Pallesen, B. Bjorvatn, B. Sivertsen, O. E. Havik, and I. H. Nordhus, “Patient characteristics and predictors of sleep medication use,” International Clinical Psychopharmacology, vol. 25, no. 2, pp. 91–100, 2010. View at Publisher · View at Google Scholar
  42. Y. Dagan, M. Dushenat, and B. Silverman, “Chronic use of sleep medications—how serious is it in Israel?” Harefuah, vol. 148, no. 5, pp. 292–351, 2009. View at Google Scholar
  43. I. A. T. Willems, W. J. Gorgels, R. C. Voshaar, J. Mulder, and P. L. Lucassen, “Tolerance to benzodiazepines among long-term users in primary care,” Family Practice, vol. 30, no. 4, pp. 404–410, 2013. View at Publisher · View at Google Scholar · View at Scopus
  44. R. P. Allen, J. Mendels, D. B. Nevins, D. A. Chernik, and E. Hoddes, “Efficacy without tolerance or rebound insomnia for midazolam and temazepam after use for one to three months,” The Journal of Clinical Pharmacology, vol. 27, no. 10, pp. 768–775, 1987. View at Publisher · View at Google Scholar
  45. S. L. Schutte-Rodin, L. Broch, D. Buysee, C. Dorsey, and M. Sateia, “Clinical guideline for the evaluation and management of chronic insomnia in adults,” Journal of Clinical Sleep Medicine, vol. 4, no. 5, pp. 487–504, 2008. View at Google Scholar · View at Scopus
  46. T. Roth, P. Berglund, V. Shahly, A. C. Shillington, J. J. Stephenson, and R. C. Kessler, “Middle-of-the-night hypnotic use in a large national health plan,” Journal of Clinical Sleep Medicine, vol. 9, no. 7, pp. 661–668, 2013. View at Publisher · View at Google Scholar · View at Scopus
  47. R. S. Carel, I. Brodsky, and G. Pillar, “Obstructive sleep apnea: comparison of syndrome severity and risk factors for adult Jewish and Arab males in Northern Israel,” Israel Medical Association Journal, vol. 17, no. 8, pp. 492–495, 2015. View at Google Scholar · View at Scopus