Research Article

Modeling and Optimization of the Drug Extraction Production Process

Table 1

Parameters used in mechanistic model.

ParameterDescriptionValue

Cross-sectional area of extraction tank (m2)3
Steam temperature before entering extraction tank (°C)125
Volume ratio of water and steam1/80
Standard heat of liquefaction of vapor (kJ/mol)40.68
Specific heat capacity of feed liquid (kJ/(kg  ×  °C))4
Specific heat capacity of water (kJ/(kg  ×  °C))4.2
Coefficient in 4.4
Coefficient in 0.001
Lifting area of oil layer (m2)2.8
Density of water (g/cm3)1
Density of volatile oil (g/cm3)0.72
Acceleration of gravity (m/s2)9.8
Diameter of oil droplet (m)
Initial concentration of volatile oil in herbs0.3
Radius of solid herb particle (m)
Thickness of liquid film (m)
Thickness of gas film (m)
Sinuosity of holes inside gray layer in solid particle1.2
Porosity of gray layer in solid particle0.98
Solubility of EC in liquid film0.85
Associating parameter of solvent2.65
Molecular weight of solvent (D)100
Molecular volume of EC (m3)
Linear equilibrium proportional constant0.15
Initial liquid level in extraction tank (m)3.5
Initial temperature of feed liquid in extraction tank (°C)20
Initial concentration of EC in solvent0
Sampling period (s)0.05