The Role of Endothelial Mesenchymal Transformation on Infantile Hemangioma

Figure 1

TGF-β1 induces EndMT in HemECs. Under the inverted phase contrast microscope, before the treatment of TGF-β1, the cells were irregular polygon with clear boundary and tight connection between cells. After 3 days of culture, the cells in the TGF-β1 group changed significantly in morphology, elongated spindle type, fuzzy boundary, and large gap, from paving stone to shuttle shape.