Nonfunctional Metastatic Parathyroid Carcinoma in the Setting of Multiple Endocrine Neoplasia Type 2A Syndrome

Table 1

Cases of PCA in the setting of MEN-2A reported in the literature.

Reference	Jenkins et al. (1997) [3]	J. J. Alfaro (2002) [4]	This case
Age (years)	47	49	54
Sex	Male	Male	Male
RET mutation	(Cys634Tyr) of exon 11	Not known mutation	(Cys618Arg) of exon 10
Clinical presentation	8-week symptoms of thirst and polyuria	Severe hypercalcemia	Asymptomatic
Serum calcium (mmol/L)*	3.3	3.77	2.3
Serum PTH (pmol/L)°	102	1399	6.1
Serum calcitonin (ng/L)^6	5110	75.8	2.1
Serum and urinary metanephrines	Normal	Normal	Normal
Tumour size (cm)	Not recorded	Not recorded	1.4
Metastases	First thoracic vertebra (T1) and right frontal bone	Lung	Cervical lymph node
Medullary carcinoma	Yes	Yes	No
Pheochromocytoma	No	No	Yes

Serum calcium normal limit (2.1–2.5 mmol/L).
Serum PTH normal limit (11–54 ng/L).
Serum calcitonin normal limit (males < 13.8 ng/L; females < 6.4 ng/L).