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Surgery Research and Practice
Volume 2015 (2015), Article ID 307879, 4 pages
Clinical Study

Evaluation of Factor VIII as a Risk Factor in Indian Patients with DVT

1Department of Vascular Surgery, The Christian Medical College, Vellore 632004, India
2Department of Transfusion Medicine and Immunohaematology, The Christian Medical College, Vellore 632004, India

Received 2 June 2015; Revised 23 August 2015; Accepted 24 August 2015

Academic Editor: Miltiadis I. Matsagkas

Copyright © 2015 Darpanarayan Hazra et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Introduction. Elevated factor VIII population in the Indian population has not been studied as a possible risk factor for deep vein thrombosis (DVT). High factor VIII level is considered a predisposing factor for DVT and its recurrence. However it is known to vary between populations and its exact role in the etiopathogenesis of thrombophilia remains unknown. Material and Methods. Factor VIII levels of patients with DVT who had undergone a prothrombotic workup as a part of their workup was compared to normal age matched controls in a 1 : 3 ratio. Results. There were 75 patients with DVT who had undergone a prothrombotic workup in the course of their treatment for lower limb DVT. In these, 64% had levels of factor VIII more than 150 as compared to 63% of normal controls (, not significant). Conclusion. Elevated factor VIII in the Indians may not be associated with the same thrombotic risk as seen in the West. We find a variation in the levels of factor VIII with a different “normal” than what is reported in other populations. This needs further study to elucidate the role of factor VIII in the evaluation and treatment of thrombophilia.