Effects of Lornoxicam on Anastomotic Healing: A Randomized, Blinded, Placebo-Control Experimental Study
Table 2
Raw data and clustered and overall comparisons of histologic variables studied between controls and lornoxicam treated subjects. Comparisons were made with Fischer exact test. Variables with statistically significant differences are presented.
Grading score
CG3
EG3
value
CG7
EG7
value
Overall
p value
CG versus EG
Depth of colon destruction
2
1/6
0/12
0.270
0/6
0/6
0.015
0.009
3
5/6
5/6
6/6
1/6
4
0/6
1/6
0/6
5/6
Fibroblast infiltration
1
0/6
4/6
0.023
0/6
2/6
0.540
0.015
2
5/6
2/6
4/6
3/6
3
1/6
0/6
2/6
1/6
Granulation tissue
1
4/6
5/6
1
0/6
4/6
0.002
0.005
2
1/6
0/6
6/6
0/6
3
1/6
1/6
0/6
2/6
Macrophage density
1
5/6
5/6
1
5/6
0/6
0.015
0.082
2
1/6
1/6
0/6
3/6
3
0/6
0/6
1/6
3/6
Reepithelization
0
0/6
4/6
0.005
0/6
0/6
1
0.049
1
0/6
2/6
0/6
0/6
2
2/6
0/6
2/6
3/6
3
4/6
0/6
3/6
3/6
4
0/6
0/6
1/6
0/6
Microabscesses
Presence
1/6
5/6
0.08
0/6
5/6
0.015
0.01
Necrosis
0
2/6
2/6
0.474
1/6
0/6
0.015
0.003
1
4/6
2/6
5/6
1/6
2
0/6
2/6
0/6
5/6
CG3: control group 3rd POD, EG3: experimental (lornoxicam) group 3rd POD, CG7: control group 7th POD, EG7: experimental (lornoxicam) group 7th POD, and : number of subjects. Statistical significance at the level of 0.05.
