Preoperative Neutrophil-Lymphocyte Ratio and Platelet-Lymphocyte Ratio Are Not Clinically Useful in Predicting Prognosis in Early Stage Cervical Cancer
Table 3
Univariate analysis of disease-free survival and overall survival.
Variable
n (%) ()
Disease-free survival
Overall survival
5-year DFS% (95% CI)
value
5-year OS% (95% CI)
value
Age
0.024
0.448
<50 years
170 (35.1)
86.6 (79.1–91.5)
97.9 (91.6–99.5)
≥50 years
314 (64.9)
89.2 (84.6–92.5)
96.5 (92.8–98.3)
Stage
0.066
0.238
IA2
45 (9.3)
97.1 (81.4–99.6)
100
IB1
439 (90.7)
87.5 (83.3–90.6)
96.7 (93.7–98.3)
Histology
<0.001
0.644
Squamous carcinoma
285 (58.9)
91.1 (86.5–94.2)
96.6 (92.6–98.5)
Adenocarcinoma
158 (32.6)
90.1 (83.2–94.3)
98.8 (91.7–99.8)
Adenosquamous carcinoma
28 (5.8)
63.8 (36.7–81.7)
95.0 (69.5–99.3)
Others
13 (2.7)
56.3 (24.4–79.1)
85.7 (33.4–97.9)
Tumor size
0.072
0.125
≤2 cm
326 (67.4)
91.1 (86.9–94.0)
98.4 (95.2–99.5)
>2 cm
158 (32.6)
82.2 (73.8–88.1)
93.5 (85.9–97.1)
Lymph vascular space invasion
0.027
0.404
No
360 (74.4)
90.5 (86.3–93.4)
97.6 (94.4–99.0)
Yes
124 (25.6)
82.1 (72.7–88.6)
94.9 (86.9–98.1)
Deep stromal invasion
<0.001
0.181
No
359 (74.2)
92.2 (88.4–94.8)
97.6 (94.4–99.0)
Yes
125 (25.8)
76.1 (65.7–83.7)
94.8 (86.6–98.1)
Parametrium involvement
0.006
0.002
No
465 (96.1)
89.4 (85.7–92.2)
97.7 (95.0–99.0)
Yes
19 (3.9)
64.2 (36.9–82.1)
80.8 (51.4–93.4)
Lymph node status
<0.001
<0.001
No
460 (95.0)
89.7 (86.0–92.4)
98.1 (95.6–99.2)
Yes
24 (5.0)
61.8 (36.0–79.7)
71.3 (39.2–88.5)
Vaginal margin
0.007
0.534
No
466 (96.3)
89.1 (85.3–92.0)
97.1 (94.3–98.6)
Yes
18 (3.7)
70.6 (43.2–86.6)
93.8 (63.2–99.1)
Adjuvant treatment
0.024
0.201
No
385 (79.6)
90.5 (86.5–93.3)
98.2 (95.2–99.3)
Yes
99 (20.4)
80.7 (69.9–88.0)
98.2 (95.2–99.3)
Hemoglobin
0.009
0.016
≥11 g/dl
430 (89.6)
90.0 (86.2–92.8)
98.0 (95.2–99.2)
<11 g/dl
50 (10.4)
73.8 (57.3–84.8)
86.8 (67.8–95.0)
White blood cell
0.468
0.892
≤10,000/µl
409 (85.4)
87.8 (83.7–91.0)
97.2 (94.2–98.7)
>10,000/µl
70 (14.6)
90.5 (78.6–96.0)
95.3 (82.4–98.8)
Platelet
0.473
0.926
≤400,000/µl
454 (94.8)
88.1 (84.2–91.1)
97.1 (94.2–98.6)
>400,000/µl
25 (5.2)
90.2 (66.2–97.5)
94.1 (65.0–99.2)
NLR
0.670
0.934
≤1.8
242 (52.4)
89.7 (84.2–93.3)
98.7 (94.9–99.7)
>1.8
220 (47.6)
85.6 (79.3–90.1)
94.8 (89.4–97.5)
PLR
0.780
0.306
≤119
231 (50.2)
87.9 (81.7–92.1)
96.8 (91.5–98.8)
>119
229 (49.8)
87.3 (81.6–91.3)
96.7 (92.2–98.6)
Numbers may not sum to total because of missing data, value based on nonmissing data. NLR = neutrophil/lymphocyte ratio; PLR = platelet/lymphocyte ratio; DFS = disease-free survival; OS = overall survival; CI = confidence interval.
