Use of Integra for Reconstruction after Nevi Resection: A Systematic Review and Pooled Analysis of Reported Cases

Table 2

Pooled data from all 13 included studies.

Patient	Age (yrs)	Gender	Site	Size (%TBSA)	Initial Integra take rate	Time to skin graft (weeks)	Type of skin coverage	Follow-up time (yrs)	Initial skin graft take rate	Complete wound healing	Complications
Schiestl et al. [8]	2.2	F	Face	2	Yes	3.1	STSG	4.08	Yes	Yes	None
	11.0	F	Face	3	Yes	3.1	STSG	4	Yes	Yes	None
	8.3	F	Trunk	2	Yes	2.7	STSG	3.6	Yes	Yes	None
	3.5	F	Trunk	10	No	4.3	STSG	0.08	Yes	Yes	Infection
	0.6	F	Trunk	2	No	2.7	STSG	2.92	Yes	Yes	No Integra take
	0.8	M	Trunk	12	Yes	2.1	STSG	2.35	Yes	Yes	None
	3.8	M	Arm	3	Yes	3	STSG	2	Yes	Yes	None
	2.5	M	Leg	3	No	2.7	STSG	1.5	Yes	Yes	None
	1.2	M	Face	1	Yes	3.1	STSG	1.35	Yes	Yes	None
	9.7	F	Trunk	4	Yes	2.9	STSG	1.15	Yes	Yes	None
	2.3	F	Arm	4	Yes	2.3	STSG	0.75	Yes	Yes	None
	1.5	F	Trunk	6	Yes	3	STSG	0.5	Yes	Yes	None
Tønseth et al. [19]	1.5	M	Trunk	16	Yes	3	STSG	0.2	Yes	Yes	Regrafting
Ramasamy and Jeffery [9]	17.0	M	Trunk	10	Yes	6	STSG	0.8	Yes	Yes	None
Ozerdem et al. [10]	6.0	M	Trunk	6	Yes	—	CEA	0.08	Yes	Yes	None
Kopp et al. [11]	44.0	F	Trunk	12	Yes	2.9	STSG	2.5	Yes	Yes	None
Kumbla et al. [12]	5.5	F	Hands/arm	2	Yes	3	STSG	1	Yes	Yes	None
	3.7	F	Hands/arm	2	Yes	3	STSG	1	Yes	Yes	None
Maguire et al. [13]	0.4	F	Trunk	26	Yes	—	STSG	5	Yes	Yes	—
Barcot et al. [14]	9.0	F	Leg/foot	5	Yes	3	STSG	2.7	Yes	Yes	—
Alrawi and Jeffery [15]	13.0	M	Trunk	16	Yes	4	STSG	13	Yes	Yes	None
	12.0	M	Thigh/leg	12	Yes	4	STSG	13	Yes	Yes	None
Earle and Marshall [16]	7.0	F	Thigh	3	Yes	—	CEA	—	Yes	Yes	—
	8.0	M	Trunk	12	Yes	—	CEA	—	Yes	Yes	—
Grunwaltd et al. [17]	11.0	M	Nose	0.005	Yes	—	FTSG	—	Yes	Yes	None
	7.0	F	Nose	0.005	Yes	—	FTSG	—	Yes	Yes	None
Abai et al. [4]	2.8	F	Leg	4	Yes	4	STSG	0.5	Yes	Yes	None
	13.0	M	Leg	4	Yes	4	STSG	1	Yes	Yes	None
	10.0	F	Trunk	4	Yes	4	STSG	2	Yes	Yes	None
	8.0	F	Trunk	6	Yes	4	STSG	1.1	Yes	Yes	None
Marano et al. [18]	2.0	M	Trunk	3	Yes	2	STSG	1	Yes	Yes	Hypertrophic scar
Totals	Mean: 7.36 yrs; SD: 7.99 yrs	M: 77%; F:33%	Trunk: 51.6%; Extremities: 32.3%; Face: 16.1%	Mean: 6.29% TBSA; SD: 5.73% TBSA	90.30%	Mean: 3.28 wks; SD: 0.83 wks	STSG: 83.9%; FTSG: 6.5%; CEA: 9.7%	Mean: 2.56 yrs; SD: 3.22 yrs	100%	100%	14.8%