Does Helium Pneumoperitoneum Reduce the Hyperinflammatory Response in Septic Animals during Laparoscopy?
Table 1
Serum levels of biomarkers of sepsis in rats after 24 h of laparoscopic cecal ligation and puncture (CLP) induced sepsis assisted by either carbon dioxide or helium pneumoperitoneum.
Biomarkers
Laparoscopy with carbon dioxide insufflation
Laparoscopy with helium insufflation
SLC
CLC
value
SLH
CLH
value
Cortisol (ng/mL)
Mean ± SD
0.72 ± 0.33
0.88 ± 0.28
>0.05
0.69 ± 0.27
0.56 ± 0.26
>0.05
Median
0.7
0.8
0.6
0.6
Minimum
0.31
0.58
0.42
0.16
Maximum
1.19
1.40
1.24
0.99
Interleukin-1 (pg/mL)
Mean ± SD
176.35 ± 73.07
48.45 ± 27.18
0.001
207.29 ± 81.65
41.99 ± 27.21
0.0001
Median
183.32
47.17
211.31
33.24
Minimum
63.25
11.26
99.70
6.97
Maximum
290.53
82.55
326.98
91.12
Interleukin-6 (pg/mL)
Mean ± SD
189.19 ± 69.10
41.50 ± 20.02
0.001
179.32 ± 111.64
56.11 ± 44.49
0.009
Median
175.05
33.75
166.51
40.14
Minimum
72.15
17.50
41.59
14.09
Maximum
305.09
74.11
361.63
146.44
Tumor nuclear factor-α (ng/mL)
Mean ± SD
16.59 ± 19.07
52.87 ± 62.85
>0.05
61.88 ± 47.52
39.91 ± 35.81
>0.05
Median
12.35
30.52
92.03
36.01
Minimum
0
0
0
0
Maximum
48
168
103
83
Differences considered statistically significant at according to Kruskal–Wallis or Mann–Whitney U tests. SD, standard deviation; SLC, sepsis laparoscopy carbon dioxide pneumoperitoneum; CLC, control laparoscopy carbon dioxide pneumoperitoneum; SLH, sepsis laparoscopy helium pneumoperitoneum; and CLH, control laparoscopy helium pneumoperitoneum.