Rare Pseudopapillary Neoplasm of the Pancreas: A 10-Year Experience

Jena, Suvendu Sekhar; Ray, Samrat; Das, Sri Aurobindo Prasad; Mehta, Naimish N; Yadav, Amitabh; Nundy, Samiran

doi:https://doi.org/10.1155/2021/7377991

Surgery Research and Practice

On this page

Abstract Introduction Methods Results Discussion Conclusion Data Availability Disclosure Conflicts of Interest Acknowledgments References Copyright Related Articles

Research Article | Open Access

Volume 2021 | Article ID 7377991 | https://doi.org/10.1155/2021/7377991

Rare Pseudopapillary Neoplasm of the Pancreas: A 10-Year Experience

Suvendu Sekhar Jena,¹Samrat Ray,¹Sri Aurobindo Prasad Das,¹Naimish N Mehta,¹Amitabh Yadav,¹and Samiran Nundy¹

Academic Editor: Cosimo Sperti

Received03 Jun 2021

Revised06 Sept 2021

Accepted08 Sept 2021

Published17 Sept 2021

Abstract

Introduction. The solid pseudopapillary epithelial neoplasm (SPN) is a rare form of pancreatic neoplasm with an incidence of 2-3% of all pancreatic tumours. The recent increase in incidence is attributed to the increasing use of imaging techniques for nonspecific abdominal complaints. We report our institutional experience in the management of this tumour over the last decade. Method. We retrospectively analyzed from a prospectively maintained database of patients from January 2011 to December 2020 who were operated upon for SPN. All the patients were followed till date. Results. Of 479 patients operated on for various types of pancreatic tumours during this period, 15 (3.1%) had SPN. The mean age of presentation was 28 years with a female preponderance (12/15, 80%). The most common location was the body and tail of the pancreas (66%), and the mean size was 6.4 cm (2–15 cm). The tumour extent was defined as ‘borderline resectable’ in 20% of cases. Distal pancreatectomy was done in 11 patients with spleen preservation in 3. R0, R1, and R2 resection were done in 12, 2, and 1 patient(s), respectively. The operative mortality was 6.7%. All the patients are doing well on follow-up. Conclusion. SPN is a low-grade malignant tumour with a strong female predilection. Clinical manifestations have no specificity, imaging examination only contributes tumour location, and the final diagnosis rests on pathology. Surgery is the main modality of treatment and carries a good prognosis.

1. Introduction

Solid pseudopapillary neoplasms (SPNs) of the pancreas are defined by the new 5th edition of the World Health Organization (WHO) Classification of Digestive System Tumors as low-grade malignant tumours composed of poorly cohesive epithelial cells which form solid and pseudopapillary structures and lack a specific line of pancreatic epithelial differentiation [1]. SPN incidence is around 2-3% of all pancreatic neoplasms. It has a female preponderance and also malignant potential [2]. A total of 8334 cases have been reported in the English literature till 2018 with an increasing incidence in recent times. This is attributed to the extended use of imaging techniques for nonspecific abdominal complaints and their better availability since most of the tumours are indolent and patients have nonspecific complaints [3]. Cubilla and Fitzgerald reported an incidence of SPN of 0.17% in 1979, Morohoshi et al. reported an incidence of 2.7% in 1987, and Koshmal et al. reported an incidence of 6.1% of all pancreatic tumours in 2004 [4–6]. Lichtenstein was the first to report this entity, but Frantz in 1959 described its pathology and Hamoudi et al. described its electron microscopy features in 1970 [7–9]. Before being defined as a tumour of uncertain differentiation or solid pseudopapillary neoplasm in 1996 by the World Health Organization, it was also known as a solid cystic tumour, papillary epithelial neoplasm, or papillary epithelial tumour [10]. It is a rare tumour and has an estimated incidence of 2-3% of all pancreatic tumours and 6–12% of all pancreatic cystic neoplasms [3]. It usually affects women below the age of 40 years (2–85 years), with a male to female ratio of 7–11 : 1. In the paediatric age group, the incidence is 8–12.5%. The usual location is the body and tail of the pancreas (55–60%) followed by the head and neck of the gland (35–40%). It is usually associated with a favourable prognosis with a long-term disease-free survival of 95% [11]. SPNs are slow-growing tumours and have a low malignant potential, and the usual symptoms are due to local manifestations of the tumour. It may occasionally present with tumour rupture or metastasis. The origin of the disease is unknown with various authors claiming different points of origin. Surgery is the mainstay of treatmentwhich depends upon the location of the tumour and ranges from distal pancreatectomy and Whipple’s pancreaticoduodenectomy, to debulking. Radiotherapy and chemotherapy have very little or no role in its management [12]. We had previously published a case report of a young girl presented with ruptured SPN in 2016 and highlighted various aspects of management [13]. The present study was done to report our institutional experience in the management of this rare tumour over the last decade.

2. Patients and Methods

We retrospectively analyzed, from a prospectively maintained database, all patients with a diagnosis of solid pseudopapillary epithelial neoplasm operated at the Department of Surgical Gastroenterology and Liver Transplantation at Sir Ganga Ram Hospital, New Delhi, over a period of 10 years from January 2011 to December 2020. Their demographic data, associated comorbidities, presenting complaints, preoperative blood parameters, and preoperative tumour markers like carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA 19-9) were analyzed. The imaging results, i.e., the ultrasound and contrast-enhanced computed tomography (CECT) of the abdomen, were also analyzed. The type of surgery performed and its complications along with the histopathology reports were also recorded, and the complications were graded according to the Clavien–Dindo classification (CDC) and comprehensive complication index (CCI) [14, 15]. The postoperative pancreatic fistula (POPF) was defined as per the definition of an international study group of pancreatic fistula. The patients were followed up till December 2020. The pancreatic exocrine functions were assessed from the symptoms and need for pancreatic enzyme supplementation, while the endocrine functions were assessed by the need for insulin or any increase in the requirement of insulin if already on insulin. The data were compared with those published from western countries as well as from India. Statistical analysis was performed using SPSS version 22.0 software. Continuous variables were reported as mean ± standard deviation (±SD). Informed consent was taken from the patients for the use of their data.

3. Results

Of 479 patients operated for various types of pancreatic tumours during this period, 15 (3.1%) were operated for SPN. They had a mean age of 28.13 (±11.2) years (11–47). Of 15 patients, 12 were female and 3 were male. Their mean body mass index (BMI) was 22.37 (±3.85) kg/meter². Only 1 patient had hypertension as an associated comorbid illness with a mean Charlson comorbidity index of 8.7.

The majority of the patients presented with a mild, dull aching type of pain (66.7%), while one patient was incidentally diagnosed while being evaluated for unexplained anaemia when she was found to have a SPN along with a uterine fibroid. One patient presented with severe abdominal pain and on evaluation was found to have a ruptured SPN. Three patients presented with a lump in the abdomen. The median size of the tumour was 6 cm (2–15 cm). The location was the body and tail of the pancreas in 5, tail in 5, and body in 3, 1 each in head and uncinate process (Table 1).

Preoperative tumour markers like the CA 19-9 and CEA, found to rule out primary pancreatic adenocarcinoma or metastatic disease, were normal in all cases. The imaging modalities used were ultrasound (USG) abdomen and CECT abdomen. USG abdomen was done in 12 patients, among whom the tumour was hypoechoic in 5, heteroechoic in 5, and isoechoic in 2 patients. CECT abdomen revealed a borderline resectable lesion in 3 patients and resectable lesion in 12 patients. The tumour was solid only in 8 patients, cystic only in 1 patient, and mixed solid and cystic in 6 patients. The cystic areas probably indicated haemorrhage into the tumour. In 14 cases, the tumours were encapsulated. Calcification was seen in 12 patients (Figure 1). Endoscopic ultrasound (EUS) was done as a part of the diagnostic procedure in 6 patients (Figure 2). 2 patients had a preoperative diagnosis other than SPN on EUS, like islet cell tumour in one patient and pancreatic cystadenoma in the other. A preoperative biopsy was done in 8 patients, among whom 6 had fine-needle aspiration cytology via EUS and 2 underwent exploration and biopsy somewhere else for a lump in the abdomen before coming here (Table 2).

(a)

(b)

All 15 patients underwent curative resection. The patient who presented with a tumour rupture underwent emergency laparotomy due to haemodynamic instability and altered sensorium. Upon exploration, around 1400 ml of blood was found in the peritoneal cavity. The mass was found to be adherent to the splenic flexure of the colon, spleen, and transverse mesocolon with complete obliteration of the lesser sac. Because of her unstable condition, peritoneal lavage and biopsy for the tumour were performed. She then received four cycles of chemotherapy using vincristine (1.5 mg/m²), actinomycin D (0.045 mg/kg), and cyclophosphamide (1200 mg/m²) to reduce the size of the tumour. The tumour response was assessed with the USG abdomen. She subsequently underwent distal pancreaticosplenectomy. This procedure was performed in a total of 11 patients with spleen-preserving distal pancreatectomy in 3 patients. Whipple’s pancreaticodudoenectomy was performed in 2 patients. One patient had a central pancreatectomy with Roux-en-Y reconstruction (Figure 3). None of the patients underwent vascular resection or reconstruction. Of 11 patients who underwent distal pancreatectomy with or without splenectomy, 6 patients underwent laparoscopic resection while 5 underwent open resection. Multivisceral resection was not required in any of the patients. The average blood loss was 228 ml. A total of 4 patients received blood transfusion. The average duration of surgery was 268.3 ± 145.8 min (Table 3).

(a)

(b)

R0 resection was performed in 12 patients, while R1 resection was performed in 2 patients. The patient, who presented with tumour rupture, initially underwent damage control surgery (R2) followed by tumour downsizing with chemotherapy and complete resection. None of the patients had lymphovascular invasion, while 1 of them showed perineural invasion. On immunohistochemical (IHC) staining, cells were stained positive for vimentin in 13 patients and synaptophysin and beta-catenin in 11. Chromogranin was negative in all 15 patients (Table 4) (Figure 4). The Ki-67 proliferation index was less than 1% in all cases. The average number of lymph nodes retrieved were 10 ( 2–24), and none of the nodes showed metastatic deposits.

(a)

(b)

(c)

(d)

(e)

Figure 4

(a) Tumour cells arranged as solid nests and pseudopapillae with intervening hyalinised vascular channels (normal pancreas) (20x). (b) Tumour appears fairly delineated, however, in places it is intermixed with pancreatic acini at the periphery. The tumour is abutting the superficial fibres of the muscularis propria of the duodenum. (c) The tumour cells are polyhedral with mildly anisomorphic nuclei having longitudinal grooves, inconspicuous nucleoli, and moderate to scant amount of eosinophilic cytoplasm (40x). (d) Beta-catenin +. (e) Synaptophysin +.

There was 1 patient with operative mortality. The patient underwent exploratory laparotomy, cholecystectomy, gastrojejunostomy, and biopsy of intra-abdominal mass elsewhere following which there was a bile leak followed by endoscopic stenting of the common bile duct. He then received 3 cycles of chemotherapy and underwent distal pancreaticosplenectomy in our hospital. He had a POPF that was managed conservatively, and he was discharged with a drain in situ. Gradually, the drain output reduced and it was removed. He was readmitted with hematemesis and hemorrhagic shock on postoperative day (POD) 45. On evaluation, there was a pseudoaneurysm of the gastroduodenal artery which was managed by angioembolization. He subsequently developed septicaemia and died on POD 88.

All the patients were followed up. At a median follow-up of 59 months (2–109), there was no recurrence. Except for the patient who underwent damage control surgery, no patient received adjuvant chemotherapy. There was no endocrine or exocrine insufficiency in any of the patients.

4. Discussion

SPN is a rare pancreatic tumour, accounting for 1-2% of all pancreatic neoplasms [16]. Unlike pancreatic adenocarcinoma, these tumours are indolent and benign with a risk of malignant transformation in around 10–15% [17]. Their cell of origin is unknown. One theory suggests it originates from multipotent primordial germ cells lacking a definite differentiation of the exocrine or endocrine cell [18]. Various authors have also described various sources of origin like the acinar cell and endocrine cell. Another theory suggests its origin from the incorporation of primitive ovarian cells within the pancreatic parenchyma during the seventh week of embryogenesis, but this does not explain its occurrence in males [19–22].

It is frequently seen in young females in their second to fourth decade of life with a female preponderance of 80% and mean age of 28.13 ± 11.2 years. Law et al. in their systematic review of 2744 patients revealed 87.8% incidence in females with an average age of 28.5 ± 13.7 years [23].

Obesity had no relation with SPN in our study which was also confirmed by Song et al. with an average BMI of 23.7 ± 2.4 kg/m² [8]. The average BMI in our study was 22.37 ± 3.85 kg/m² (14.3–27.8). There are some reports of an association between hepatitis B virus and SPN due to overexpression of beta-catenin in tumour cells, but none of our patients had hepatitis B [24].

The symptoms are mostly nonspecific, and abdominal pain caused by the mass is the most common manifestation with nausea and vomiting being other symptoms [3]. The subtle nature of their presentation leads to a delay in diagnosis, resulting in large tumours found at that time. However, the size of the lesion does not affect resectability [25]. SPNs are usually bulky tumours (median tumour size 6 cm in our study). Despite their large size, they usually do not invade the surrounding structures but only displace them, so symptoms like obstructive jaundice and pancreatitis are rare. Abdominal pain was the most common mode of presentation seen in 66.7% of our cases followed by a lump in 20%. Incidental detection was seen in one. Usually, it is restricted to the pancreas in approximately 85% of cases, while 10–15% of cases present with metastases [23]. The most common sites of metastasis are the liver, regional lymph nodes, omentum, and peritoneum [26]. None of our patients had metastasis during their presentation.

Although rare, rupture of the tumour can also be a mode of presentation that can either be spontaneous or following blunt trauma to the abdomen. The reported incidence of rupture in the literature is 2.7% with blunt trauma to the abdomen being the most common cause [27]. The incidence of spontaneous rupture is 1% of all SPN and thought to be due to sudden massive haemorrhage causing a rise in pressure inside. One 11-year-old young girl presented to us with a sudden onset of abdominal pain with haemodynamic instability and underwent debulking because of bleeding and infiltration of the surrounding structures.

The most common location of the tumour was the body and tail of the pancreas in 80% of cases. Law et al. in their meta-analysis showed 59.3% located in the body and tail of the pancreas [23], and one of the largest meta-analyses conducted by Yao et al. in 2450 Chinese patients also showed the most common location to be the body and tail of the pancreas. In contrast, Panieri et al. showed an equal spatial distribution of the tumour [28, 29]. The size of the tumour or its location did not predict malignancy as reported by Yu et al. [30]. Ectopic locations have also been described in the retro peritoneum, mesentery, and left adrenal gland [28]. None of our patients had an ectopic location.

No additional information in our series was provided by the haematological investigations, while hyperamylasaemia, elevated hepatic enzymes, and leukocytosis were occasionally identified [24]. In tumour markers like carbohydrate antigen 19-9 and carcinoembryonic antigen did not contribute to the diagnosis. In preoperative assessment, radiological studies are the most important. Abdominal roentgenograms can demonstrate displacement of the stomach, colon, or spleen by an extrinsic mass [31]. Calcification is seldom encountered within the large mass. However, calcifications are peripheral and curvilinear when present, as compared to the pattern of sunburst defined in microcystic adenomas [32]. Ultrasonography, CT scan, and MRI typically demonstrate the same characteristics with an encapsulated tumour composed of solid and cystic elements, often with capsule rim-like calcifications as well as intraparenchymal calcifications. The lesion has well-defined margins often without pancreatic duct dilation. Ultrasonography demonstrates hypoechoic, isoechoic, or heteroechoic components, while CT shows solid or cystic components with calcification. MRI and positron emission tomography can also be used. MRI is better than CT in various aspects like demonstration of a capsule and solid or cystic degeneration [33]. None of the radiological findings are specific for SPN, and similar findings can also be seen in other cystic neoplasms and pancreatoblastoma. Endoscopic ultrasound and fine-needle aspiration were used in 40% of cases. Preoperative tissue diagnosis is not always necessary but can be used in cases of uncertain diagnosis [12].

Distal pancreatectomy with or without splenectomy was performed in 11 (73.3%) cases, and Whipple’s pancreaticoduodenectomy was performed in 2 (13.3%) patients. Although no patients in our study required vascular resection, various studies have shown excellent long-term survival after vascular or multivisceral resection [34, 35]. Extensive lymphadenectomy is not done always due to the low incidence of lymph node metastases [12]. No patient showed lymphovascular invasion in our study, and all the resected nodes were negative for tumour deposits. Metastatectomy also improves long-term outcomes [12]. Debulking of a locally advanced tumour also has a role as shown by a previous case report from our institution [13]. Enucleation is also another option for moving small tumours away from the duct but carries a risk of fistulae and tumour dissemination. Complete R0 resection was performed in 80% of patients, while 13.3% had an R1 resection. It is difficult to differentiate between the malignant and benign varieties as the criteria for malignancy is not clear cut. As per the WHO classification, the clear-cut criteria for malignant varieties are lymphovascular or perineural invasion and liver or lymph node metastases which are known as pseudopapillary carcinoma. A size of more than 5 cm, capsular invasion, high Ki-67 proliferation index, and growth into peripancreatic tissue are also linked with malignancy by a few authors [36]. Nishihara et al. proposed venous invasion, high nuclear grade, and prominent necrobiotic nests as indicators of malignancy [37]. Only one patient had a perineural invasion in our study and is surviving 5 years after surgery without any recurrence. All our patients had a low Ki-67 proliferation index of <1%.

The most common complication following surgery was postoperative pancreatic fistula, probably due to the soft nature of the pancreas, which was seen in 8 (53.3%) patients of which grade A fistula, that is a biochemical leak, was seen in 6 patients while grades B and C were seen in one patient each. There was one patient with mortality having grade C fistula, following distal pancreaticosplenectomy due to sepsis and haemorrhage from a gastroduodenal artery pseudoaneurysm on POD 88.

On histopathology, SPN is a cellular neoplasm with cells arranged in several layers around a fibrovascular stalk giving a pseudopapillary appearance. The presence of a pseudopapillary structure, hyaline globules, cholesterol clefts, foamy macrophages, and nuclear grooving in the absence of salt-pepper chromatin on histopathology are characteristics of SPN. Immunohistochemical markers are also peculiar to SPN and can be used to differentiate it from various conditions like cystic neoplasms of the pancreas, pancreatoblastoma, acinic cell tumour, and neuroendocrine tumours [36]. Beta-catenin and Wnt signaling pathway have been found to play an important role in the tumorigenesis and are consistently positive in 90% of cases of SPN, which is consistent with our study where beta-catenin was found to be positive in 86.6%. The other consistently positive markers were vimentin, neuron-specific enolase, and α1-antitrypsin. The neuroendocrine markers, except chromogranin A which is consistently negative in SPN, like synaptophysin, neuron-specific enolase, and CD 56 also showed variable expression [37, 38]. The positive expression of the progesterone receptor was also seen in 53.35% of patients suggesting an origin from ovarian cells.

The literature regarding the use of adjuvant chemotherapy is limited with various authors trying gemcitabine, oxaliplatin, irinotecan, and etoposide in various combinations postoperatively and reporting disease stability. Various authors also used chemotherapy to downstage the tumour and in turn facilitated surgery and prolonged survival. Radiation can be used in case of an unresectable tumour to provide a better quality of life and even a survival benefit. Selective internal chemotherapy has also been described. Tamoxifen is a viable option for metastatic disease in patients who are poor candidates for chemotherapy [39]. In our study, one patient who had presented with tumour rupture underwent debulking initially due to her haemodynamic instability, received chemotherapy, and underwent definitive resection at a later stage after downstaging of her tumour.

The overall five-year survival rate after surgery is around 95–97% [40]. According to Yu et al., the estimated 1-, 3-, and 5-year survival rates were 99.4%, 97.5%, and 96.9%, respectively [41]. The tumour recurrence rate was <10% [42]. In our study, at a median follow-up of 59 months (2–109), there was no recurrence of the tumour and none of the patients has signs of exocrine or endocrine insufficiency.

5. Conclusion

To conclude, although rare, SPN are treatable tumours, the origin of which is still an enigma. Mostly seen in young females, they have a nonspecific presentation. They can be readily identified by radiological imaging, while typical histological and immunochemical markers separate these from their close counterparts. Because of the risk of malignant transformation and for good survival, resection is the best option. The size of the tumour does not predict the outcome. Locally advanced tumours can be given chemotherapy to downstage them for a definitive resection. Aggressive lymphadenectomy is not required.

Data Availability

Data are available with the corresponding author and can be reproduced upon request.

Disclosure

This work was presented at the Indian Association of Surgical Gastroenterology Conference in 20/02/2021 as a free paper, conducted virtually by the Department of Surgical Gastroenterology and Liver Transplantation, Sir Ganga Ram Hospital.

Conflicts of Interest

The authors declare no conflicts of interest.

Acknowledgments

The authors thank Mr. Parmanand Tiwari, executive, for his help in data maintenance.

References

G. Kloppel, O. Basturk, D. S. Klimstra, L. Ak, and K. Notohara, “Solid pseudo-papillary neoplasm of the pancreas,” in Tumors of Pancreas. In Who Classification of Tumors Editorial Board Eds: WHO Classification of Tumours. Digestive System Tumours, International Agency for Research on Cancer (IARC), A. J. Gill, D. S. Klimstra, A. K. Lam, and M. K. Washington, Eds., pp. 340–342, 5th edition, 2019.
View at: Google Scholar
A. L. Mulkeen, P. S. Yoo, and C. Cha, “Less common neoplasms of the pancreas,” World Journal of Gastroenterology, vol. 12, no. 20, p. 3180, 2006.
View at: Publisher Site | Google Scholar
R. Casadei, D. Santini, L. Calculli, R. Pezzilli, N. Zanini, and F. Minni, “Pancreatic solid-cystic papillary tumor: clinical features, imaging findings and operative management,” JOP: Journal of the Pancreas, vol. 7, pp. 137–144, 2006.
View at: Google Scholar
A. L. Cubilla and P. J. Fitzgerald, “Cancer of the pancreas (nonendocrine): a suggested morphologic classification,” Seminars in Oncology, vol. 6, pp. 285–297, 1979.
View at: Google Scholar
T. Morohoshi, M. Kanda, A. Horie et al., “Immunocytochemical markers of uncommon pancreatic tumors. Acinar cell carcinoma, pancreatoblastoma and solid cystic (papillary-cystic) tumor,” Cancer, vol. 59, no. 4, pp. 739–747, 1987.
View at: Publisher Site | Google Scholar
M. Kosmahl, L. S. Seada, U. Jänig, D. Harms, and G. Klöppel, “Solid-pseudopapillary tumor of the pancreas: its origin revisited,” Virchows Archiv, vol. 436, no. 5, pp. 473–480, 2000.
View at: Publisher Site | Google Scholar
L. Lichtenstein, “Papillary cystadenocarcinoma of pancreas: case report, with notes on classification of malignant cystic tumors of pancreas,” American Journal of Cancer, vol. 21, no. 3, pp. 542–553, 1934.
View at: Publisher Site | Google Scholar
H. Song, M. Dong, J. Zhou, W. Sheng, B. Zhong, and W. Gao, “Solid pseudopapillary neoplasm of the pancreas: clinicopathologic feature, risk factors of malignancy and survival analysis of 53 cases from a single center,” BioMed Research International, vol. 2017, Article ID 5465261, 7 pages, 2017.
View at: Publisher Site | Google Scholar
A. B. Hamoudi, K. Misugi, J. L. Grosfeld, and C. B. Reiner, “Papillary epithelial neoplasm of pancreas in a child.Report of a case with electron microscopy,” Cancer, vol. 26, no. 5, pp. 1126–1134, 1970.
View at: Publisher Site | Google Scholar
F. Eder, H. U. Schulz, C. Röcken, and H. Lippert, “Solid-pseudopapillary tumor of the pancreatic tail,” World Journal of Gastroenterology, vol. 11, no. 26, p. 4117, 2005.
View at: Publisher Site | Google Scholar
S. Gurzu, T. Bara, M. Sincu et al., “Solid pseudopapillary neoplasm of pancreas: two case reports,” Medicine, vol. 98, Article ID e16455, 2019.
View at: Publisher Site | Google Scholar
N. A. N. Kumar, M. S. Bhandare, V. Chaudhari, S. P. Sasi, and S. V. Shrikhande, “Analysis of 50 cases of solid pseudopapillary tumor of pancreas: aggressive surgical resection provides excellent outcomes,” European Journal of Surgical Oncology, vol. 45, no. 2, pp. 187–191, 2019.
View at: Publisher Site | Google Scholar
S. K. Jha, V. Mangla, S. Lalwani et al., “Solid pseudo-papillary neoplasm of pancreas: an unusual presentation and management,” JOP. J Pancreas (Online), vol. 17, pp. 440–443, 2016.
View at: Google Scholar
P. A. Clavien, J. Barkun, M. L. De Oliveira et al., “The clavien-dindo classification of surgical complications,” Annals of Surgery, vol. 250, no. 2, pp. 187–196, 2009.
View at: Publisher Site | Google Scholar
K. Slankamenac, R. Graf, J. Barkun, M. A. Puhan, and P.-A. Clavien, “The comprehensive complication index,” Annals of Surgery, vol. 258, no. 1, pp. 1–7, 2013.
View at: Publisher Site | Google Scholar
W. M. Hackeng, R. H. Hruban, G. J. Offerhaus, and L. A. Brosens, “Surgical and molecular pathology of pancreatic neoplasms,” Diagnostic Pathology, vol. 11, pp. 47–7, 2016.
View at: Publisher Site | Google Scholar
C. M. Kang, K. S. Kim, J. Sub Choi, H. Kim, W. Jung Lee, and B. Ro Kim, “Solid pseudopapillary tumor of the pancreas suggesting malignant potential,” Pancreas, vol. 32, no. 3, pp. 276–280, 2006.
View at: Publisher Site | Google Scholar
D. Santini, F. Poli, and S. Lega, “Solid-papillary tumors of the pancreas: histopathology,” JOP : Journal of the Pancreas, vol. 7, pp. 131–136, 2006.
View at: Google Scholar
J. A. Bombí, A. Milla, J. M. Badal, J. Piulachs, J. Estape, and A. Cardesa, “Papillary-cystic neoplasm of the pancreas. Report of two cases and review of the literature,” Cancer, vol. 54, no. 4, pp. 780–784, 1984.
View at: Publisher Site | Google Scholar
M. Ladanyi, S. Mulay, J. Arseneau, and P. Bettez, “Estrogen and progesterone receptor determination in the papillary cystic neoplasm of the pancreas. With immunohistochemical and ultrastructural observations,” Cancer, vol. 60, no. 7, pp. 1604–1611, 1987.
View at: Publisher Site | Google Scholar
G. M. Learmonth, S. K. Price, A. E. Visser, and M. Emms, “Papillary and cystic neoplasm of the pancreas-an acinar cell tumour?” Histopathology, vol. 9, no. 1, pp. 63–79, 1985.
View at: Publisher Site | Google Scholar
M. R. Lieber, E. E. Lack, J. R. Roberts et al., “Solid and papillary epithelial neoplasm of the pancreas an ultrastructural and immunocytochemical study of six cases,” The American Journal of Surgical Pathology, vol. 11, no. 2, pp. 85–93, 1987.
View at: Publisher Site | Google Scholar
J. K. Law, A. Ahmed, V. K. Singh et al., “A systematic review of solid-pseudopapillary neoplasms,” Pancreas, vol. 43, no. 3, pp. 331–337, 2014.
View at: Publisher Site | Google Scholar
G. Q. Sun, C. Q. Chen, J. Y. Yao, H. P. Shi, Y. L. He, and W. H. Zhan, “Diagnosis and treatment of solid pseudopapillary tumor of pancreas: a report of 8 cases with review of domestic literature,” Chinese Journal of General Surgery, vol. 17, pp. 902–907, 2008.
View at: Google Scholar
A. N. Kingsnorth, S. W. Galloway, H. Lewis-Jones, J. R. Nash, and P. A. Smith, “Papillary cystic neoplasm of the pancreas: presentation and natural history in two cases,” Gut, vol. 33, no. 3, pp. 421–423, 1992.
View at: Publisher Site | Google Scholar
L. H. Tang, H. Aydin, M. F. Brennan, and D. S. Klimstra, “Clinically aggressive solid pseudopapillary tumors of the pancreas,” The American Journal of Surgical Pathology, vol. 29, no. 4, pp. 512–519, 2005.
View at: Publisher Site | Google Scholar
H.-L. Huang, S. C. Shih, W. H. Chang, T. E. Wang, M. J. Chen, and Y. J. Chan, “Solid-pseudopapillary tumor of the pancreas: clinical experience and literature review,” World Journal of Gastroenterology, vol. 11, no. 9, p. 1403, 2005.
View at: Publisher Site | Google Scholar
J. Yao and H. Song, “A review of clinicopathological characteristics and treatment of solid pseudopapillary tumor of the pancreas with 2450 cases in Chinese population,” BioMed Research International, vol. 2020, Article ID 2829647, 11 pages, 2020.
View at: Publisher Site | Google Scholar
E. Panieri, J. E. J. Krige, P. C. Bornman, S. M. Graham, J. Terblanche, and J. P. Cruse, “Operative management of papillary cystic neoplasms of the pancreas,” Journal of the American College of Surgeons, vol. 186, no. 3, pp. 319–324, 1998.
View at: Publisher Site | Google Scholar
P. Yu, X. Cheng, Y. Du et al., “Solid pseudopapillary neoplasms of the pancreas: a 19-year multicenter experience in China,” Journal of Gastrointestinal Surgery, vol. 19, no. 8, pp. 1433–1440, 2015.
View at: Publisher Site | Google Scholar
R. B. Rustin, T. A. Broughan, R. E. Hermann, S. F. Grundfest-Broniatowski, R. E. Petras, and W. R. Hart, “Papillary cystic epithelial neoplasms of the pancreas,” Archives of Surgery, vol. 121, no. 9, pp. 1073–1076, 1986.
View at: Publisher Site | Google Scholar
I. S. Sheen, C. S. Chang-Chien, and C. S. Wu, “Solid and papillary neoplasm of the pancreas: a report of an unusual pattern of calcification,” American Journal of Gastroenterology, vol. 83, no. 7, pp. 789–91, 1988.
View at: Google Scholar
C.-C. Yu, J. H. Tseng, C. N. Yeh, T. L. Hwang, and Y. Y. Jan, “Clinicopathological study of solid and pseudopapillary tumor of pancreas: emphasis on magnetic resonance imaging findings,” World Journal of Gastroenterology, vol. 13, no. 12, p. 1811, 2007.
View at: Publisher Site | Google Scholar
K. Cheng, B. Shen, C. Peng, F. Yuan, and Q. Yin, “Synchronous portal-superior mesenteric vein or adjacent organ resection for solid pseudopapillary neoplasms of the pancreas: a single-institution experience,” The American Surgeon, vol. 79, no. 5, pp. 534–539, 2013.
View at: Publisher Site | Google Scholar
C. Sperti, M. Berselli, C. Pasquali, D. Pastorelli, and S. Pedrazzoli, “Aggressive behaviour of solid-pseudopapillary tumor of the pancreas in adults: a case report and review of the literature,” World Journal of Gastroenterology, vol. 14, no. 06, p. 960, 2008.
View at: Publisher Site | Google Scholar
C. P. Hansen, T. S. Kristensen, J. H. Storkholm, and B. H. Federspiel, “Solid pseudopapillary neoplasm of the pancreas: clinical-pathological features and management, a single-center experience,” Rare Tumors, vol. 11, 2019.
View at: Publisher Site | Google Scholar
K. Nishihara, M. Nagoshi, M. Tsuneyoshi, K. Yamaguchi, and I. Hayashi, “Papillary cystic tumors of the pancreas assessment of their malignant potential,” Cancer, vol. 71, no. 1, pp. 82–92, 1993.
View at: Publisher Site | Google Scholar
N. Bhutani, P. Kajal, S. Singla, and V. Sangwan, “Solid pseudopapillary tumor of the pancreas: experience at a tertiary care centre of Northern India,” International Journal of Surgery Case Reports, vol. 39, pp. 225–230, 2017.
View at: Publisher Site | Google Scholar
A. Bansal, V. Kaushal, and R. Kapoor, “Solid pseudopapillary tumors of the pancreas: is there a role for adjuvant treatment?” Saudi Surgical Journal, vol. 4, no. 2, p. 47, 2016.
View at: Publisher Site | Google Scholar
R. C. G. Martin, D. S. Klimstra, M. F. Brennan, and K. C. Conlon, “Solid-pseudopapillary tumor of the pancreas: a surgical enigma?” Annals of Surgical Oncology, vol. 9, no. 1, pp. 35–40, 2002.
View at: Publisher Site | Google Scholar
P.-F. Yu, Z. H. Hu, X. B. Wang et al., “Solid pseudopapillary tumor of the pancreas: a review of 553 cases in Chinese literature,” World Journal of Gastroenterology, vol. 16, no. 10, p. 1209, 2010.
View at: Publisher Site | Google Scholar
T. Papavramidis and S. Papavramidis, “Solid pseudopapillary tumors of the pancreas: review of 718 patients reported in English literature,” Journal of the American College of Surgeons, vol. 200, no. 6, pp. 965–972, 2005.
View at: Publisher Site | Google Scholar

Copyright

Copyright © 2021 Suvendu Sekhar Jena et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PDF Download Citation

Download other formats

Order printed copies

Views

890

Downloads

751

Citations