Clinical Analysis on Alteration of Thyroid Hormones in the Serum of Patients with Acute Ischemic Stroke

Table 1

Characteristics of acute ischemic stroke patients with low T3 and normal T3 values.

	Low T3 group	Normal T3 group	$P$-value
	($\text{T}3\le 75$ ng/dL)	($\text{T}3>75$ ng/dL)
	$n=29$	$n=18$
Clinical variables
Age (years)	68.1 ($\pm$12.7)	66.8 ($\pm$11.5)	NS
Sex (% male)	18 (62.1%)	11 (61.1%)	NS
Smoking	9 (31.0%)	6 (33.3%)	NS
Hypercholesterolemia	8 (27.6%)	5 (27.8%)	NS
Coronary artery disease	5 (17.2%)	3 (16.7%)	NS
Diabetes mellitus	9 (31.0%)	6 (33.3%)	NS
Atrial fibrillation	6 (20.1%)	4 (22.2%)	NS
History of hypertension	19 (65.5%)	11 (61.1%)	NS
BP on admission
Systolic BP (mmHg)	156.2 ($\pm$27.9)	150.2 ($\pm$29.5)	NS
Diastolic BP (mmHg)	89.7 ($\pm$11.4)	87.8 ($\pm$14.2)	NS
Baseline NIHSS scores	11.5 ($\pm$3.5)	6.6 ($\pm$4.3)	<.05
Distribution of NIHSS scores
Mild (<8)	2 (6.9%)	15 (83.3%)	<.01
Moderate (8–14)	17 (58.6%)	2 (11.1%)	<.01
Severe (≥14)	10 (34.5%)	1 (5.6%)	<.01
Laboratory variables
Anterior carotid artery territory	11 (37.9%)	7 (38.9%)	NS
Posterior/basilar artery territory	6 (20.1%)	4 (22.2%)	NS
Thyroid function tests
TSH ($\mu$U/mL)	1.24 ($\pm$1.19)	1.30 ($\pm$1.21)	NS
T3 (ng/dL)	53.1 ($\pm$11.7)	109.5 ($\pm$21.6)	<.01
T4 (ng/dL)	8.5 ($\pm$3.04)	9.2 ($\pm$2.6)	NS
Initial WBC count	7.8 ($\pm$3.9)	7.3 ($\pm$2.5)	NS
Initial hemoglobin	9.4 ($\pm$1.4)	9.1 ($\pm$1.8)	NS
Glucose on admission (mmol/L)	135.6 ($\pm$56.8)	128.9 ($\pm$55.4)	<.05
Medications
Antiplatelets/Anticoagulants	14 (48.3%)	9 (50%)	NS

Numbers for nominal data indicate percentages in parentheses and for continuous data indicate mean $\pm$ standard deviation. Statistical significance ($P<.05$). NS: no statistical significance; BP: blood pressure; NIHSS: National Institutes of Health Stroke Scale; Baseline NIHSS scores: the initial scores on admission; TSH: thyroid-stimulating hormone; T3: triiodothyronine; T4: thyroxine; Antiplatelets/Anticoagulants: ASA or Plavix or coumadin.