Case Report | Open Access
Intracranial Vertebrobasilar Artery Dissection Associated with Postpartum Angiopathy
Background. Cervicocephalic arterial dissection (CCAD) is rare in the postpartum period. To our knowledge this is the first reported case of postpartum angiopathy (PPA) presenting with ischemic stroke due to intracranial arterial dissection. Case. A 41-year-old woman presented with blurred vision, headache, and generalized seizures 5 days after delivering twins. She was treated with magnesium for eclampsia. MRI identified multiple posterior circulation infarcts. Angiography identified a complex dissection extending from both intradural vertebral arteries, through the basilar artery, and into both posterior cerebral arteries. Multiple segments of arterial dilatation and narrowing consistent with PPA were present. Xenon enhanced CT (Xe-CT) showed reduced regional cerebral blood flow that is improved with elevation in blood pressure. Conclusion. Intracranial vertebrobasilar dissection causing stroke is a rare complication of pregnancy. Eclampsia and PPA may play a role in its pathogenesis. Blood pressure management may be tailored using quantitative blood flow studies, such as Xe-CT.
1. Case Report
A 41-year-old pregnant woman with no other past medical history presented to a community hospital with pre-eclampsia at 36-week gestation. She had a systolic blood pressure (SBP) of 160 mmHg with proteinuria but no neurologic signs or symptoms. Twins were delivered by emergent Cesarean section under spinal anesthesia without apparent complications. She was discharged home on hospital day 5.
The following day she developed a severe headache, blurred vision, and SBP 160 mmHg. She had a generalized tonic-clonic seizure in the emergency department. She was orotracheally intubated for airway protection, treated with magnesium sulfate, levetiracetam, and labetalol. She had no further clinical seizures. A noncontrast CT of the head was normal. After extubation the following day, she became lethargic, and her mental status rapidly declined. MRI of the brain showed several areas of acute infarction in the posterior circulation. She was transferred to our neurological intensive care unit (NeuroICU) for further evaluation on the third day of hospitalization.
On presentation to our facility, she was lethargic and opened her eyes only to repeated tactile stimulation. She was oriented to name, could follow simple commands, and was severely dysarthric with incomprehensible speech. She had a right homonymous hemianopia, disconjugate gaze, and was quadriparetic. She was treated with a magnesium infusion, intravenous levetiracetam, aspirin 325 mg daily, and a nicardipine infusion which was titrated to maintain a goal SBP less than 120 mmHg. On the third day of hospitalization at our institution she became comatose, and her SBP was persistently 130 mmHg despite aggressive medical therapy. Continuous EEG showed diffuse slowing but no epileptiform activity. MRI of the brain redemonstrated multiple acute infarcts isolated to the posterior circulation (Figure 1).
There was a small area of hemorrhagic transformation of the left occipital lobe infarct seen on gradient echo images (not shown). MRA of the head and neck revealed patent cervical arteries with an apparent dissection flap visualized throughout the basilar artery (Figure 2).
A conventional angiogram confirmed a “double lumen” within the basilar artery with possible involvement of both intradural vertebral arteries, a finding specific for a vertebrobasilar dissection [1, 2]. In addition, distinct from the vertebrobasilar dissection, there were multiple regions of segmental narrowing and dilatation of the intracranial arteries predominantly in the posterior circulation, consistent with concomitant PPA (Figure 3).
Given the radiographic findings there was uncertainty whether the patient’s elevated blood pressure was contributing to her clinical deterioration or whether it was a compensatory mechanism to improve perfusion of ischemic tissue. To better direct management of her blood pressure, a Xenon enhanced CT (Xe-CT) was performed to quantify cerebral blood flow (CBF) at different blood pressures. This study showed areas of decreased relative cerebral blood volume in the bilateral posterior cerebral, right middle cerebral, and left anterior cerebral vascular territories at an SBP of 120 mmHg which improved by allowing the SBP to rise above 130 mmHg (Figure 4).
The Mg infusion was discontinued at that time, and her blood pressure target was changed to an SBP of 130 mmHg. Her neurological examination improved slowly over the next several weeks. She was discharged to an acute rehabilitation facility on hospital day 30. At the time of discharge, she was awake, alert, and oriented to person, place, and year. She had a dense right homonymous hemianopia and a moderate right hemiparesis. She required intermittent enteral feeding through a percutaneous gastrostomy tube.
Three months after hospital discharge, she remained in an acute rehabilitation facility. She continued to clinically improve. The gastrostomy tube had been removed, and she could walk with assistance. She continued to have significant memory difficulties and vision loss.
Cervicocephalic arterial dissection (CCAD) is a rare postpartum complication only previously described in case reports and one recent small case series, involving a total of 6 patients [3–7]. The general annual incidence of symptomatic spontaneous CCAD is reported to be about 2.6 cases per 100000 . A recent registry database identified 2.4% of cases of spontaneous CCAD occurred in the postpartum period . Extrapolating this data would indicate that postpartum CCAD is as rare as 6.2 cases per 10000000 annually. In general, ischemic stroke complicating pregnancy and the postpartum period is also an uncommon condition with a reported incidence of 4.3 cases per 100000 deliveries . In a series of 348295 consecutive deliveries, the most common cause of ischemic stroke was identified as eclampsia in 7 (47%) cases. The remaining etiologies were reported to be one case, each of extracranial vertebral artery dissection, PPA, amniotic fluid embolism with disseminated intravascular coagulation, and protein S deficiency. No etiology was determined in four cases.
The relationship between CCAD and the postpartum period remains unclear. A traumatic mechanism from strenuous labor is unlikely to be the mechanism in most cases. All 6 of the patients reported by Arnold et al. had uneventful deliveries with symptomatic dissection occurring at least 5 days postpartum, as did our patient who delivered via C-section and did not become symptomatic until day 6. A more likely association exists between CCAD and an acquired vasculopathy. In the prior series of spontaneous CCAD, 4/6 (67%) of patients who were postpartum had neuroimaging characteristics consistent with reversible cerebral vasoconstriction syndrome (RCVS), reversible posterior leukoencephalopathy (RPLS), or cortical subarachnoid hemorrhage (cSAH) without associated intradural dissection, while only 3/96 (3%) patients in the age and sex matched controls had similar findings . Literature suggests that conditions such as pre-eclampsia/eclampsia, RCVS, PPA, and RPLS are all likely variable expressions of a common disease, but the underlying pathophysiology is poorly understood . A common unifying theme is that surges in blood pressure and vasoactive or angiogenic substances damage the endothelial lining of vessels causing blood-brain-barrier dysfunction and accumulation of extracellular vasogenic edema. Placental growth factor (PlGF), soluble PlGF receptor (sFlt-1), and soluble endoglin are factors in the angiogenesis pathway which have been implicated in the development of PPA and eclampsia [11–13]. The resulting vessel injury causes cerebral autoregulatory dysfunction and segmental alterations in vessel tone with variable areas of arterial narrowing and dilatation [10, 14, 15].
Aggressive blood pressure reduction is accepted as the treatment of hypertension in the RCVS syndromes including PPA and eclampsia [16, 17]. There are no clinical trials that have assessed treatment thresholds in these settings. There is a general consensus to lower blood pressures to less than 160/110 mmHg in patients with pre-eclampsia or eclampsia . However, these recommendations are based on expert opinion and not guided by data from clinical trials. There are no clear treatment guidelines directing blood pressure management in patients with other cerebral vasoconstriction syndromes; however we routinely strive for normotensive blood pressure goals. The current American Heart Association/American Stroke Association guidelines for the management of blood pressure in acute stroke recommend permissive hypertension . There seems to be no clear solution to the management of blood pressure in patients with RCVS and acute infarcts as these accepted treatments are antagonistic. In this setting, additional diagnostic studies that provide perfusion information, such as Xe-CT, CT perfusion, or MRI perfusion, can be helpful to guide management.
This is the first reported case of an intracranial vertebrobasilar dissection causing ischemic stroke in a patient with PPA and eclampsia. This is significant because of the uniqueness of the case and the uncertainty about blood pressure management. A flow-limiting intracranial dissection may alter the optimal target blood pressure. Blood pressure management tailored to the individual patient’s cerebral hemodynamic needs is likely the best solution to optimizing CBF to areas of relative ischemia while avoiding excessive elevations in perfusion pressure which can exacerbate RCVS. Xe-CT has been utilized to determine CBF in acute stroke, differentiate between normal, ischemic, and irreversibly infarcted tissue, and optimize hemodynamic treatment parameters [20–22]. It has also previously been reported to show changes in regional CBF in a patient with eclampsia . Xe-CT was used in our case to help direct our blood pressure management by presumably increasing CBF to areas of relative ischemia, while minimizing the perfusion pressure needed to accomplish this goal.
Intracranial vertebrobasilar dissection is a rare postpartum complication and likely occurs in vessels with endothelial damage from associated underlying conditions such as eclampsia and PPA. Antihypertensive therapy to treat these diseases may exacerbate ischemia in patients with concurrent cerebral infarction. Individualized therapy, utilizing methods to quantify CBF, may allow clinicians to optimize treatment of their patients and warrants further study.
- C.-H. Kim, Y.-J. Son, S. H. Paek et al., “Clinical analysis of vertebrobasilar dissection,” Acta Neurochirurgica, vol. 148, no. 4, pp. 395–404, 2006.
- T. Hosoya, M. Adachi, K. Yamaguchi, T. Haku, T. Kayama, and T. Kato, “Clinical and neuroradiological features of intracranial vertebrobasilar artery dissection,” Stroke, vol. 30, no. 5, pp. 1083–1090, 1999.
- E. Van de Kelft, J. Kunnen, L. Truyen, and L. Heytens, “Postpartum dissecting aneurysm of the basilar artery,” Stroke, vol. 23, no. 1, pp. 114–116, 1992.
- J. Abisaab, N. Nevadunsky, and N. Flomenbaum, “Emergency department presentation of bilateral carotid artery dissections in a postpartum patient,” Annals of Emergency Medicine, vol. 44, no. 5, pp. 484–489, 2004.
- T. Inoue, S. Nishimura, N. Hayashi, Y. Numagami, H. Takazawa, and M. Nishijima, “Postpartum dissecting aneurysm of the posterior cerebral artery,” Journal of Clinical Neuroscience, vol. 14, no. 6, pp. 576–581, 2007.
- J. M. Waidelich, A. S. Bullough, and J. M. Mhyre, “Internal carotid artery dissection: an unusual cause of postpartum headache,” International Journal of Obstetric Anesthesia, vol. 17, no. 1, pp. 61–65, 2008.
- M. Arnold, M. Camus-Jacqmin, C. Stapf et al., “Postpartum cervicocephalic artery dissection,” Stroke, vol. 39, no. 8, pp. 2377–2379, 2008.
- W. I. Schievink, B. Mokri, and J. P. Whisnant, “Internal carotid artery dissection in a community: Rochester, Minnesota, 1987–1992,” Stroke, vol. 24, no. 11, pp. 1678–1680, 1993.
- T. Sharshar, C. Lamy, and J. L. Mas, “Incidence and causes of strokes associated with pregnancy and puerperium: a study in public hospitals of Ile de France,” Stroke, vol. 26, no. 6, pp. 930–936, 1995.
- A. B. Singhal, “Postpartum angiopathy with reversible posterior leukoencephalopathy,” Archives of Neurology, vol. 61, no. 3, pp. 411–416, 2004.
- R. J. Levine, S. E. Maynard, C. Qian et al., “Circulating angiogenic factors and the risk of preeclampsia,” The New England Journal of Medicine, vol. 350, no. 7, pp. 672–683, 2004.
- R. J. Levine, C. Lam, C. Qian et al., “Soluble endoglin and other circulating antiangiogenic factors in preeclampsia,” The New England Journal of Medicine, vol. 355, no. 10, pp. 992–1005, 2006.
- A. B. Singhal, W. T. Kimberly, P. W. Schaefer, and E. T. Hedley-Whyte, “Case 8-2009: a 36-year-old woman with headache, hypertension, and seizure 2 weeks post partum,” The New England Journal of Medicine, vol. 360, no. 11, pp. 1126–1137, 2009.
- J. Hinchey, C. Chaves, B. Appignani et al., “A reversible posterior leukoencephalopathy syndrome,” The New England Journal of Medicine, vol. 334, no. 8, pp. 494–500, 1996.
- M. C. Morriss, D. M. Twickler, M. R. Hatab, G. D. Clarke, R. M. Peshock, and F. G. Cunningham, “Cerebral blood flow and cranial magnetic resonance imaging in eclampsia and severe preeclampsia,” Obstetrics and Gynecology, vol. 89, no. 4, pp. 561–568, 1997.
- G. G. Zeeman, “Obstetric critical care: a blueprint for improved outcomes,” Critical Care Medicine, vol. 34, supplement 9, pp. S208–S214, 2006.
- A. Ducros, M. Boukobza, R. Porcher, M. Sarov, D. Valade, and M.-G. Bousser, “The clinical and radiological spectrum of reversible cerebral vasoconstriction syndrome. A prospective series of 67 patients,” Brain, vol. 130, no. 12, pp. 3091–3101, 2007.
- “Report of the National High Blood Pressure Education Program Working Group on High Blood Pressure in Pregnancy,” American Journal of Obstetrics and Gynecology, vol. 183, no. 1, pp. S1–S22, 2000.
- H. P. Adams Jr., G. del Zoppo, M. J. Alberts et al., “Guidelines for the early management of adults with ischemic stroke: a guideline from the American Heart Association/American Stroke Association Stroke Council, Clinical Cardiology Council, Cardiovascular Radiology and Intervention Council, and the Atherosclerotic Peripheral Vascular Disease and Quality of Care Outcomes in Research Interdisciplinary Working Groups: The American Academy of Neurology affirms the value of this guideline as an educational tool for neurologists,” Circulation, vol. 115, no. 20, pp. e478–e534, 2007.
- R. R. Pindzola and H. Yonas, “The xenon-enhanced computed tomography cerebral blood flow method,” Neurosurgery, vol. 43, no. 6, pp. 1488–1492, 1998.
- A. M. Kaufmann, A. D. Firlik, M. B. Fukui, L. R. Wechsler, C. A. Jungries, and H. Yonas, “Ischemic core and penumbra in human stroke,” Stroke, vol. 30, no. 1, pp. 93–99, 1999.
- M. M. Kilpatrick, H. Yonas, S. Goldstein et al., “CT-based assessment of acute stroke: CT,CT angiography, and xenon-enhanced CT cerebral blood flow,” Stroke, vol. 32, no. 11, pp. 2543–2549, 2001.
- K. Yamaguchi, Y. Fukuuchi, S. Nogawa, T. Dembo, Y. Tomita, and K. Tanaka, “Recovery of decreased local cerebral blood flow detected by the xenon/CT CBF method in a patient with eclampsia,” The Keio Journal of Medicine, vol. 49, supplement 1, pp. A71–A74, 2000.
Copyright © 2010 James S. McKinney et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.