Stroke Research and Treatment / 2010 / Article / Tab 1

Review Article

Recanalization Therapies in Acute Ischemic Stroke: Pharmacological Agents, Devices, and Combinations

Table 1

Arterial occlusions and recanalization patterns in some clinical trials in acute ischemic stroke.

TRIALTreatmentNumber of patientsHighest reported recanalization rate (%)Assessment of recanalization

NINDSActiveIV-TPA312None
ControlPlacebo312

DIASActiveDesmopletase (IV)71 (Total)49MRA-complete or partial recanalization
Part-l25 mg1656
37.5/50 mg1346
Part-262.5 mg/kg1323
90 mg/kg1547
125 mg/kg1471
ControlPlacebo26 (Total)19
Part-11619
Part-21020

PROACT-II (TIMI 2 + 3)ActivelAr-proUK12166Cerebral angiography (TIMI 2 + 3)
ControlPlacebo5918

EMSActiveIV + IA TPA1181Cerebral angiography
ControlPlacebo + IA TPA1050

MERCIActiveMERCI ± LyticCerebral angiography (any recanalization)
MCA8045
ICA4753
VAIBA1450
Control

CLOTBUST (at 2 hours)ActiveIV-TPA + TCD6338TCD
ControlIV-TPA6313

TRUMBIActiveIV-TPA + Ultrasound1429.3MRA
ControlIV-TPA1250.0