Effectiveness of Thrombolytic Therapy in Acute Embolic Stroke due to Infective Endocarditis
Table 1
Clinical characteristics and outcomes of reported cases of thrombolysis in infective endocarditis.
Ref. no
Year
Age
Gender
IE suspected
Organism
Fever
Symptoms
Admission NIHSS Score
Imaging prior to thrombolysis
Thrombolytic used
Time interval
Microaneurysms
Discharge NIHSS score Bleeding complication
1
2003
31
F
Prethrombolysis
Streptococcus mitis
Absent
Limb weakness Vertigo Tinnitus Gaze palsies
13
CT scan: hypodensity of thalamus
Intra-arterial urokinase
5h
None on CT
NIHSS score 5, no hemorrhage
8
2009
12
F
Post thrombolysis
Streptococcus pneumoniae
Present
Acute hemiparesis Aphasia
18
MRI: multiple diffusion-restricted lesions; MRA absent flow in the left internal carotid artery
Intra-arterial t-PA
6h
None on MRI
NIHSS score 5, no hemorrhage
19
2007
56
M
Post thrombolysis
Beta-hemolytic streptococcus
Present
Acute hemiparesis Aphasia
15
CT scan: loss of insular ribbon with indistinctness of lentiform nuclei, no hypodensity
Intravenous t-PA
2h, 36 min
Unknown
NIHSS score 4, no hemorrhage
Our case
2009
70
M
Post thrombolysis
Streptococcus pneumonia
Present
Acute hemiparesis Aphasia
13
CT scan: hypodensity
Intravenous t-PA
2h, 30 min
None on MRA
NIHSS score 5, no hemorrhage
IE: infective endocarditis; M: male; F: female; NIHSS: National Institute of Health Stroke Scale; CT: computed tomography; MRI: magnetic resonance imaging; MRA: magnetic resonance angiography.
