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Stroke Research and Treatment
Volume 2011, Article ID 186424, 6 pages
Research Article

Comparison of the Effectiveness of Three Methods of Recanalization in a Model of the Middle Cerebral Artery: Thrombus Aspiration via a 4F Catheter, Thrombus Aspiration via the GP Thromboaspiration Device, and Mechanical Thrombectomy Using the Solitaire Thrombectomy Device

1School of Medicine, Keele University, Staffordshire ST5 5BG, UK
2Institute for Science and Technology in Medicine, Keele University, Keele, Staffordshire ST6 6TP, UK
3Biomedical Science Division, University of Wolverhampton, Wolverhampton WV1 1LY, UK
4Department of Vascular Surgery, University Hospital of North Staffordshire, Newcastle Road, Staffordshire ST4 6QG, UK
5Stroke Research Offices, North Staffordshire Royal Infirmary, Princes Road, Stoke-on-Trent, Staffordshire ST4 7LN, UK
6Neuroradiology, University Hospital North Staffordshire, Princes Road, Stoke-on-Trent, Staffordshire ST4 7LN, UK

Received 29 November 2010; Revised 25 January 2011; Accepted 17 February 2011

Academic Editor: Graham S. Venables

Copyright © 2011 Christopher Tennuci et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Introduction. This paper compares different approaches to recanalization in a model of the middle cerebral artery (MCA). Methods. An occlusive thrombus (lamb's blood) was introduced into the MCA of a model of the cerebral circulation perfused with Hartmann's solution (80 pulsations/min, mean pressure 90 mm Hg). Three methods of clot retrieval were tested: thrombus aspiration via a 4F catheter ( ), thrombus aspiration via the GP thrombus aspiration device (GPTAD) ( ), and mechanical thrombectomy via the Solitaire Device ( ). Results. Recanalization rate was similar for all 3 approaches (62%, 77%, and 85%). Time to recanalization was faster with aspiration devices (41 SD 42 s for 4F and 61 SD 21 s for GPTAD) than with the Solitaire (197 SD 64 s Kruksal-Wallis). Clot fragmentation was the same in the Solitaire (23%) and the GPTAD (23%), but higher with the 4F (53%, ). Conclusion. In this model, thrombus aspiration was faster than mechanical thrombectomy, and similarly effective at recanalization. These results should be confirmed in vivo.