Ischemic Stroke during Pregnancy and Puerperium

Table 4

Case reports describing the use of thrombolytic treatments in ischemic stroke during pregnancy and puerperium.

Author, year	Thrombolysis	Dosage	Maternal age	Gestational age	Maternal complications	Fetal outcome	Associated conditions
Dapprich, 2002	IV rt-PA	0,9 mg/kg	31 y	12 week	minor hemorrhagic imbition of infarct area	good	Protein S deficiency
Elford, 2002	IA rt-PA	15.5 rng	28 y	I week	hematoma in basal ganglia	good	Ovarian hyperstimulation syndrome
Johnson, 2005	IA rt-PA	15 rng	39 y	37 week	none	good	Undeterminated cause
							Elevated IgG and IgM anti-cardiolipin
Leonhardt, 2006	IV rt-PA	0,9 mg/kg	26 y	23 week	basal ganglia infarction	good	Antibodies
Murugappan, 2006	^aIV rt-PA	0,9 mg/kg	37 y	12 week	intrauterine hematoma	MTP	Mitral valve replacement
	^bIV rt-PA	0,9 mg/kg	31 y	4 week	none	MTP	decreased protein S activity
	^cIV rt-PA	0,9 mg/kg	29 y	6 week	death from dissection during angioplasty	died	Aortic valve replacement
	^dIA rt-PA	21 rng	43 y	37 week	none	good	AT III, protein C and S deficiencies
	^eIA UK	600 000 U	28 y	6 week	buttock hematoma	good	protein C and S deficiencies, PFO
	^flocal UK	700 000 U	25 y	frrst trimester	asymptomatic ICH	SA	bacterial endocarditis
Wiese, 2006	IV rt-PA	0,9 mg/kg	33 y	13 week	none	good	mitral valve replacement
				fifteen hours after
Mendez, 2008	IA UK	100 000 U	37 y	cesarean delivery 6 days after	none		Undeterminated cause
Ronning, 2010	IA rt-PA	20 rng	29 y	delivery	none		Peripartum cardiomyopathy

IV: intravenous; IA: intra-arterial; rt-PA: recombinant tissue plasminogen activator; UK: urokinase; ICH: intracerebral hemorrhage; MTP: medical termination of pregnancy; SA: spontaneous abortion.