Table of Contents Author Guidelines Submit a Manuscript
Stroke Research and Treatment
Volume 2011 (2011), Article ID 712903, 18 pages
Review Article

Hereditary Connective Tissue Diseases in Young Adult Stroke: A Comprehensive Synthesis

1Center for Medical Genetics, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium
2Department of Neurology, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium

Received 15 September 2010; Revised 15 December 2010; Accepted 23 December 2010

Academic Editor: Turgut Tatlisumak

Copyright © 2011 Olivier M. Vanakker et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Though the genetic background of ischaemic and haemorrhagic stroke is often polygenetic or multifactorial, it can in some cases result from a monogenic disease, particularly in young adults. Besides arteriopathies and metabolic disorders, several connective tissue diseases can present with stroke. While some of these diseases have been recognized for decades as causes of stroke, such as the vascular Ehlers-Danlos syndrome, others only recently came to attention as being involved in stroke pathogenesis, such as those related to Type IV collagen. This paper discusses each of these connective tissue disorders and their relation with stroke briefly, emphasizing the main clinical features which can lead to their diagnosis.