Clinical Study
Intravenous Thrombolytic Treatment in the Oldest Old
Table 2
Clinical outcome and haemorrhagic complications.
| | <85 y-o | Oldest Old | Group comparison
value |
| | Patients lost to followup (%) | 79 (5.65) | 13 (12.26) | | | NIHSS score at 24 hours, median (IQR) | 6 (2–15) | 11 (4–19) | <0.001 | | NIHSS score at day 7, median (IQR) | 3 (0–11) | 6 (1–16.5) | 0.005 | | Long-term outcome parameters (day 90) | | | | | Favourable outcome (mRS 0-1), (%) | 594 (45) | 29 (31.2) | 0.009 | | Independent outcome (mRS 0–2), (%) | 772 (58.7) | 37 (40.2) | 0.001 | | Moderate disability, severe disability, or death (mRS 3–6), (%) | 541 (41.1) | 55 (59.8) | 0.001 | | Mortality (%) | 155 (11.5) | 26 (28) | <0.001 | | Causes of death | | | | | Ischaemic stroke, (%) | 60 (42.3) | 9 (36) | ns | | SICH, (%) | 16 (11.3) | 1 (4) | ns | | Myocardial Infarction, (%) | 5 (3.5) | 1 (4) | ns | | Pneumonia, (%) | 41 (28.9) | 12 (48) | ns | | Pulmonary thromboembolism, (%) | 1 (0.7) | 0 | ns | | Other vascular causes, (%) | 7 (4.9) | 2 (8) | ns | | Hemorrhagic transformation | | | | | AICH, (%) | 201 (16%) | 15 (16%) | 0.983 | | SICH, (%) | 48 (3.7) | 3 (3.1) | 1.000 |
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NIHSS: National Institutes of Health Stroke Scale; mRS: Modified Rankin Scale; IQR: interquartile range. SICH: symptomatic intracranial haemorrhage; AICH: Asymptomatic intracranial haemorrhage. Statistical significance .
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