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Stroke Research and Treatment
Volume 2013, Article ID 394036, 9 pages
Review Article

Early Brain Injury: A Common Mechanism in Subarachnoid Hemorrhage and Global Cerebral Ischemia

1Division of Neurosurgery, St. Michael's Hospital, 30 Bond Street, Toronto, ON, Canada M5B 1W8
2Labatt Family Centre of Excellence in Brain Injury and Trauma Research, Keenan Research Centre, Li Ka Shing Knowledge Institute of St. Michael's Hospital, 209 Victoria Street, Toronto, ON, Canada M5B 1T8
3Department of Surgery, University of Toronto, 30 Bond Street, Toronto, ON, Canada M5B 1W8

Received 11 December 2012; Accepted 27 January 2013

Academic Editor: Ryszard M. Pluta

Copyright © 2013 Mohammed Sabri et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Early brain injury (EBI) has become an area of extreme interest in the recent years and seems to be a common denominator in the pathophysiology of global transient ischemia and subarachnoid hemorrhage (SAH). In this paper, we highlight the importance of cerebral hypoperfusion and other mechanisms that occur in tandem in both pathologies and underline their possible roles in triggering brain injury after hemorrhagic or ischemic strokes.