Advances in Our Understanding of “Resistance” to Antiplatelet Agents for Prevention of Ischemic Stroke

Table 1

Select steps in platelet activation [16].

	(1) Receptor complexes tether platelets to sites of vascular injury: glycoprotein Ib/V/IX and platelet surface collagen receptors glycoprotein VI and Ia
	(2) Mediators of adhesion phase, and amplification and sustenance of platelet response: adenosine diphosphate (ADP), thrombin, epinephrine, and TXA2
	(3) Final activation pathway by involvement of agonists: activation of platelet integrin glycoprotein IIb/IIIa receptor for adhesion and aggregation

TXA2: thromboxane A2.