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Stroke Research and Treatment
Volume 2014, Article ID 234095, 9 pages
http://dx.doi.org/10.1155/2014/234095
Clinical Study

Autologous Bone Marrow Mononuclear Cells Intrathecal Transplantation in Chronic Stroke

1Department of Medical Services and Clinical Research, NeuroGen Brain and Spine Institute, Stemasia Hospital and Research Centre, Plot No. 19, Sector 40, Near Seawoods Railway Station, Nerul, Navi Mumbai, Maharashtra 400706, India
2Department of Research and Development, NeuroGen Brain and Spine Institute, Stemasia Hospital and Research Centre, Plot No. 19, Sector 40, Near Seawoods Railway Station, Nerul, Navi Mumbai, Maharashtra 400706, India
3Department of Neurorehabilitation, NeuroGen Brain and Spine Institute, Stemasia Hospital and Research Centre, Plot No. 19, Sector 40, Near Seawoods Railway Station, Nerul, Navi Mumbai, Maharashtra 400706, India

Received 9 April 2014; Revised 17 June 2014; Accepted 22 June 2014; Published 8 July 2014

Academic Editor: Wuwei Feng

Copyright © 2014 Alok Sharma et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Cell therapy is being widely explored in the management of stroke and has demonstrated great potential. It has been shown to assist in the remodeling of the central nervous system by inducing neurorestorative effect through the process of angiogenesis, neurogenesis, and reduction of glial scar formation. In this study, the effect of intrathecal administration of autologous bone marrow mononuclear cells (BMMNCs) is analyzed on the recovery process of patients with chronic stroke. 24 patients diagnosed with chronic stroke were administered cell therapy, followed by multidisciplinary neurorehabilitation. They were assessed on functional independence measure (FIM) objectively, along with assessment of standing and walking balance, ambulation, and hand functions. Out of 24 patients, 12 improved in ambulation, 10 in hand functions, 6 in standing balance, and 9 in walking balance. Further factor analysis was done. Patients of the younger groups showed higher percentage of improvement in all the areas. Patients who underwent cell therapy within 2 years after the stroke showed better changes. Ischemic type of stroke had better recovery than the hemorrhagic stroke. This study demonstrates the potential of autologous BMMNCs intrathecal transplantation in improving the prognosis of functional recovery in chronic stage of stroke. Further clinical trials are recommended. This trial is registered with NCT02065778.