Role of Matrix Metalloproteinase Activity in the Neurovascular Protective Effects of Angiotensin Antagonism
Figure 3
Effects of candesartan alone and in combination with FeTPPS and GM6001 on infarct size (a, d), edema (b, e), and hemoglobin content (c, f) at 24 h after MCAO. Infarct size and Hb content were significantly reduced in all three treatment groups in FeTTPS compared to the saline treated group (). Candesartan alone and in combination with GM6001 did not reduce these outcomes when administered with DMSO, but GM6001 alone resulted in a significantly reduced infarct size. Values are mean ± SEM ().
