Role of Matrix Metalloproteinase Activity in the Neurovascular Protective Effects of Angiotensin Antagonism
Figure 4
Effects of candesartan alone and in combination with FeTPPS and GM6001 on neurobehavioral tests: Bederson scores (a, d), beam walk (c, e), and paw grasp (c, f) at 24 h after MCAO. All three treatment groups in FeTTPS demonstrated improved behavior compared to the saline treated group (). Candesartan did not affect neurobehavioral outcomes when administered with DMSO, but the combination of candesartan with GM6001 resulted in significantly improved outcomes in Bederson score and paw grasp. Values are mean ± SEM ().
