Sex, Diastolic Blood Pressure, and Outcome after Thrombolysis for Ischemic Stroke

Table 3

Interaction by gender and diastolic blood pressure and influence on (a) 3-month favorable mRS and (b) 3-month mortality.

(a)

	(% favourable mRS)	Univariable			Multivariable^a			Multivariable^b			Multivariable^c
		OR	95% CI		OR	95% CI		OR	95% CI		OR	95% CI
Sex^1
Men	162 (70.4)	Reference
Women	149 (66.4)	0.8	0.5–1.3	0.5	0.9	0.5–1.8	0.9	1.7	0.7–3.9	0.2
DBP^2
>90 mmHg	68 (63.2)	Reference
<90 mmHg	240 (70.0)	1.4	0.7–2.4	0.3				3.6	1.5–8.9	0.005
DBP males
>90 mmHg	46 (60.9)	Reference
<90 mmHg	115 (74.8)	1.9	0.9–3.9	0.08							5.7	1.7–20	0.006
DBP females
>90 mmHg	22 (68.2)	Reference
<90 mmHg	125 (65.6)	0.9	0.4–2.3	0.8							1.5	0.3–8.1	0.6
Interactions sex and DBP
Male >90 mmHg	46 (60.9)										Reference
Female >90 mmHg	22 (68.2)										5.3	0.9–32.0	0.07
Male <90 mmHg	115 (74.8)										5.9	1.9–18.7	0.001
Female <90 mmHg	125 (65.6)										7.9	2.4–26.0	0.001

Abbreviations: DBP: diastolic blood pressure; mRS: modified rankin scale; 3-month favorable mRS: 3 month modified rankin scale ≤2.
Model 1^a: associations adjusted for hypertension, cholesterol and HDL-cholesterol and diastolic blood pressure. Model 1^b: associations adjusted for age, baseline NIHSS, favourable mRS before treatment, hypertension, cholesterol and HDL-cholesterol and diastolic blood pressure. Model 2^b: associations adjusted for age, baseline NIHSS, favourable mRS before treatment, cholesterol and HDL-cholesterol, sex, ASA and antihypertensive treatment. Model^c: associations adjusted for age, baseline NIHSS, favourable mRS before treatment, hypertension, cholesterol, HDL-cholesterol, ASA and antihypertensive treatment. In the final multivariable analyses 247 patients were included.

(b)

	(% mortality)	Univariable			Multivariable^a			Multivariable^b
		OR	95% CI		OR	95% CI		OR	95% CI
Sex^1
Women	159 (14.5)	Reference
Men	185 (8.1)	0.5	0.3–1.0	0.06	2.1	0.5–9.3	0.3
DBP^2
>90 mmHg	77 (9.1)	Reference
<90 mmHg	264 (9.1)	1.3	0.6–3.1	0.5				0.7	0.2–2.9	0.6
DBP males
>90 mmHg	54 (9.3)	Reference
<90 mmHg	130 (7.7)	0.8	0.3–2.5	0.7				0.6	0.1–5.8	0.5
DBP females
>90 mmHg		Reference
<90 mmHg		1.9	0.4–8.9	0.4				4.3	0.1–143	0.4
Interactions sex and DBP^3
Male >90 mmHg	54 (9.3)							Reference
Female >90 mmHg	23 (8.7)							0.05	0.01–2.0	0.4
Male <90 mmHg	130 (7.7)							0.3	0.03–2.4	0.2
Female <90 mmHg	134 (15.7)							0.1	0.02–1.7	0.1

Abbreviations: DBP: diastolic blood pressure; mRS: modified rankin scale; 3-month favorable mRS: 3 month modified rankin scale ≤2. Model 1^a: associations adjusted for age, baseline NIHSS, favourable mRS before treatment, hypertension, cholesterol and HDL-cholesterol and diastolic blood pressure. Model 2^b: associations adjusted for age, sex, baseline NIHSS, favourable mRS before treatment, cholesterol, HDL-cholesterol, acetyl salicylic acid and antihypertensive treatment. Model 3^b: associations adjusted for age, baseline NIHSS, favourable mRS before treatment, hypertension, cholesterol, HDL-cholesterol, acetyl salicylic acid, hypertension and antihypertensive treatment. In the final multivariable analyses 247 patients were included.