Stroke Research and Treatment

Research Article

Thrombin Generation in Acute Ischaemic Stroke

Table 1

Demographic characteristics of all participants.


Criteria	Subject ()	Control ()

Age, mean (SD)	71 ± 11.4	70 ± 17.6
Male, n (%)	44 (23.4)	26 (37.0)
Ethnicity
African-Caribbean, (%)	58 (30.9)	26 (36.6)
Caucasians, (%)	130 (69.1)	45 (63.3)
Risk factors
Hypertension, (%)	111 (59.0)	7 (9.9)
Diabetes mellitus, (%)	43 (22.3)	3 (4.2)
Smoking, (%)	31 (16.5)	2 (2.2)
Atrial fibrillation, (%)	43 (22.9)	—
Dyslipidaemia, (%)	47 (25.0)	—
IHD, (%)	43 (22.9)	—
Peripheral vascular disease, (%)	6 (3.2)	—
BMI, mean kg/m² (SD)	27.6 ± 5.7	28 ± 5.6
Medications
Antiplatelets, (%)	14 (7.5)	—
Statins, (%)	44 (23.4)	—
Antihypertensive, (%)	59 (31.4)	5 (7)
rtPA, (%)	63 (33.5)	(—)
No rtPA, (%)	109 (58.0)	(—)
Stroke type (TOAST criteria)
ICH, (%)	16 (9.4)	(—)
Large artery atherosclerosis, (%)	35 (20.5)	(—)
Lacunar, (%)	67 (39.4)	(—)
Cardioembolic, (%)	39 (22.9)	(—)
Unknown, (%)	9 (5.2)	(—)
Other causes, (%)	4 (2.3)	(—)
Time to acquisition of tested variables
NIHSS, median (IQR), min	28 (17, 42)	(—)
Barthel index, median (IQR), min	28 (17, 42)	(—)
NCCT, median (IQR), hours	3.8 (0.5, 23)	(—)
Sample collection, median (IQR), hours	19 (10, 36)	(—)
DtN time (rtPA), median (IQR), hours	47 (34, 84)	(—)

(—): not relevant; IHD: ischaemic heart disease; rtPA: recombinant tissue plasminogen activator; PICH: primary intracerebral haemorrhage; NIHSS: National Institute of Health Stroke scale; NCCT: noncontrast computerised tomography; DtN: door to needle time.