Safety and Efficacy of Acute Clopidogrel Load in Patients with Moderate and Severe Ischemic Strokes

Table 2

Demographic and outcome variables according to NIHSS score and load status.

	NIHSS ≥ 4, not loaded	NIHSS ≥ 4, loaded	value
Age, median years (min–max)	65 (19–103)	65 (31–99)	0.989
African American, number (%)	269 (70.6%)	151 (72.3%)	0.757
Gender, number of females (%)	184 (48.3%)	98 (46.9%)	0.744
Hyperlipidemia	148 (39.2%)	95 (45.7%)	0.125
HTN	294 (77.6%)	174 (83.7%)	0.080
Smoking	121 (31.8%)	78 (38.1%)	0.131
DM	141 (37.9%)	74 (36.3%)	0.699
Prior stroke	179 (47.2%)	107 (51.2%)	0.357
Glucose on admission	124 (61–831)	116 (57–574)	0.207
Atrial fibrillation	59 (15.7%)	21 (10.1%)	0.060
Dual Plavix and aspirin	0 (0.0%)	184 (91.5%)	<0.001
Admission NIHSS, median (min–max)	9 (4–37)	8 (4–31)	0.005
Length of stay, median (min–max)	8 (0–95)	7 (1–52)	0.001
Inpatient complications	139/291 (47.8%)	54/137 (39.4%)	0.105
UTI	67 (17.6%)	31 (14.8%)	0.383
Pneumonia	42 (11.0%)	17 (8.2%)	0.271
Recurrent thrombotic events	190 (51.5%)	86 (41.8%)	0.025
Neuroworsening%	179 (48.3%)	81 (38.9%)	0.031
Poor functional outcome (mRS > 2)	311 (81.6%)	152 (72.7%)	0.012
Unfavorable disposition	29 (10.9%)	11 (16.9%)	0.178
NIHSS d/c	6 (0–42)	4 (0–42)	0.002
mRS discharge, median (min–max)	4 (0–6)	3 (0–6)	<0.001
mRS 0–2	70 (18.4%)	57 (27.3%)	0.012
mRS 3-4	200 (52.5%)	114 (54.6%)	0.633
mRS 5-6	111 (29.1%)	38 (18.2%)	0.003
Hemorrhagic infarct in 36 h on F/uCT1 or F/uCT2	56 (24.8%)	24 (24.2%)	0.918
Symptomatic hemorrhage F/uCT1 or F/uCT2	2 (0.9%)	2 (1.8%)	0.599