Stroke Research and Treatment / 2016 / Article / Tab 1 / Research Article
Effect of Treatment Delay, Stroke Type, and Thrombolysis on the Effect of Glyceryl Trinitrate, a Nitric Oxide Donor, on Outcome after Acute Stroke: A Systematic Review and Meta-Analysis of Individual Patient from Randomised Trials Table 1 Baseline characteristics of enrolled patients by GTN versus no GTN and by trial. Data from the ENOS trial are divided by time to randomisation (
6 hours, 6–48 hours). Data are number (%), median (interquartile range), or mean (standard deviation).
Trial All GTN No GTN GTN-1 [25 ] GTN-2 [26 ] GTN-3 [27 ] RIGHT [20 ] ENOS-early [21 ] ENOS-rest [21 ] 2 Number 4197 2113 2084 37 90 18 41 273 3738 Age (yrs) 70.4 (12.1) 70.4 (12.1) 70.4 (12.2) 73.7 (9.1) 71.8 (11.8) 69.4 (7.4) 76.3 (11) 69.9 (12.7) 70.3 (12.1) 0.012 Male (%) 2383 (56.8) 1198 (56.7) 1185 (56.9) 18 (48.6) 41 (45.6) 5 (27.8) 22 (53.7) 154 (56.4) 2143 (57.3) 0.029 Stroke (%) 623 (15.0) 336 (16.0) 287 (13.9) NC 15 (16.7) 3 (16.7) 11 (26.8) 39 (14.3) 555 (14.8) 0.30 HT (%) 2700 (64.3) 1338 (63.3) 1362 (65.4) 23 (62.2) 36 (40) 7 (38.9) 27 (65.9) 168 (61.5) 2439 (65.2) <0.001 DM (%) 715 (17.2) 354 (16.9) 361 (17.5) NC 12 (13.3) 0 (0.0) 4 (9.8) 37 (13.6) 662 (17.7) 0.049 IHD (%) 686 (16.5) 353 (16.8) 333 (16.1) NC 13 (14.4) 2 (11.1) 2 (4.9) 34 (12.5) 635 (17) 0.062 AF (%) 597 (14.4) 318 (15.2) 279 (13.5) NC 18 (20) 0 (0.0) 8 (19.5) 38 (13.9) 533 (14.3) 0.18 SBP (mmHg) 167.1 (19.3) 167.1 (19.2) 167 (19.4) 161.9 (21.5) 159.2 (27) 163.3 (16.5) 172.5 (28.2) 166.7 (18.2) 167.3 (19) <0.001 Minimum 101 101 110 126 101 137 137 132 110 Maximum 234 234 233 219 224 191 234 223 233 >140 (%) 3976 (94.7) 2000 (94.7) 1976 (94.8) 32 (86.5) 62 (68.9) 16 (88.9) 40 (97.6) 262 (96) 3564 (95.3) <0.001 DBP (mmHg) 89.5 (13.3) 89.7 (13.3) 89.3 (13.4) 91.6 (15.7) 86.8 (16.3) 90.4 (14.9) 92.1 (19.9) 90.8 (13.3) 89.4 (13.1) 0.11 HR (bpm) 77.5 (14.8) 77.8 (14.9) 77.3 (14.6) 77.3 (15.7) 78 (15.2) 68.2 (14) 82.5 (18) 77.5 (14.9) 77.5 (14.7) 0.036 SSS (/58) 33.7 (13.2) 34 (13.1) 33.5 (13.3) NC 32.6 (11.7) 42.1 (10.5) 35.7 (17) 32.1 (11.9) 33.8 (13.3) 0.010 IS (%) 3502 (83.4) 1759 (83.2) 1743 (83.6) 33 (89.2) 84 (93.3) 16 (88.9) 27 (65.9) 208 (76.2) 3134 (83.8) <0.001 ICH (%) 646 (15.4) 323 (15.3) 323 (15.5) 4 (10.8) 5 (5.6) 2 (11.1) 6 (14.6) 61 (22.3) 568 (15.2) 0.003 OTR (hours) 27.2 (16.1) 27.1 (16.4) 27.2 (15.8) 99.2 (38) 55.1 (18.9) 72.2 (26.2) 1.6 (1.8) 4.3 (1.2) 27.6 (11.9) <0.001 <6 hours 312 (7.4%) 168 (8) 144 (6.9) 0 (0.0) 0 (0.0) 0 (0.0) 39 (95.1) 273 (100) 0 (0.0) <0.001 rt-PA (%) 435 (10.4) 211 (10) 224 (10.7) 0 (0.0) 0 (0.0) 0 (0.0) 10 (24.4) 93 (34.1) 332 (8.9) <0.001
Stroke severity measured after randomisation at hospital admission. Percentage includes IS and ICH patients. AF: atrial fibrillation; bpm: beats per minute; DBP: diastolic blood pressure; DM: diabetes mellitus; GTN: glyceryl trinitrate; HR: heart rate; HT: hypertension; ICH: intracerebral haemorrhage; IHD: ischaemic heart disease; IS: ischaemic stroke; OTR: onset time to randomisation; rt-PA: recombinant tissue-plasminogen activator/alteplase; SBP: systolic blood pressure; SSS: Scandinavian Stroke Scale.