Renal Dysfunction Is an Independent Risk Factor for Poor Outcome in Acute Ischemic Stroke Patients Treated with Intravenous Thrombolysis: A New Cutoff Value
Table 3
Univariate analysis of clinical characteristics of all patients.
Baseline characteristics
Poor outcome (mRS 3–6)
Mortality
SICH
Age
1.04 (1.03–1.06) value < 0.001
1.06 (1.03–1.09) value < 0.001
1.02 (0.98–1.06) p value = 0.194
Sex
0.74 (0.50–1.11) p value = 0.157
0.89 (0.54–1.47) p value = 0.656
1.05 (0.47–2.36) p value = 0.889
Onset to time (each minute)
1.002 (0.998–1.006) p value = 0.332
1.001 (0.996–1.006) p value = 0.332
1.00 (0.99–1.01) p value = 0.163
NIHSS (each point)
1.24 (1.18–1.30) value < 0.001
1.14 (1.08–1.21) value < 0.001
1.06 (0.98–1.15) p value = 0.109
SBP (each mm Hg)
1.002 (0.998–1.006) p value = 0.640
1.005 (0.996–1.015) p value = 0.235
1.00 (0.98–1.01) p value = 0.806
DBP (each mm Hg)
1.002 (0.992–1.011) p value = 0.745
1.004 (0.992–1.016) p value = 0.495
1.01 (0.99–1.03) p value = 0.119
Glucose (each mg/dL)
1.007 (1.004–1.010) value < 0.001
1.006 (1.003–1.009) value < 0.001
1.004 (1.000–1.008) value = 0.028
Diabetes mellitus
2.43 (1.54–3.82) value < 0.001
1.37 (0.81–2.33) p value = 0.239
1.90 (0.83–4.32) p value = 0.125
Smoking
0.52 (0.34–0.81) value = 0.004
0.72 (0.41–1.27) value = 0.268
0.84 (0.34–2.07) value = 0.708
Hyperlipidemia
0.87 (0.58–1.31) p value = 0.517
0.58 (0.33–1.02) value = 0.061
1.20 (0.51–2.81) p value = 0.671
Hypertension
1.52 (1.00–2.31) value = 0.049
1.25 (0.73–2.15) p value = 0.414
1.70 (0.66–4.37) p value = 0.414
Atrial fibrillation
1.45 (0.93–2.26) value = 0.095
1.56 (0.92–2.66) value = 0.101
1.18 (0.49–2.85) p value = 0.706
Previous stroke or TIA
0.83 (0.43–1.61) p value = 0.590
0.45 (0.15–1.31) p value = 0.147
0.37 (0.04–2.84) p value = 0.343
Previous use of antithrombotics
1.34 (0.82–2.19) p value = 0.690
1.44 (0.76–2.73) p value = 0.258
1.27 (0.51–3.19) p value = 0.598
Decreasing GFR (by 10 mL/min/1.73 m2)
1.19 (1.09–1.30) value < 0.001
1.18 (1.06–1.32) value = 0.002
1.05 (0.88–1.24) value = 0.561
DBP = diastolic blood pressure; GFR = glomerular filtration rate; mRS = modified Rankin Scale; NIHSS = NIH Stroke Scale; SBP = systolic blood pressure; SICH = symptomatic intracranial hemorrhage. Data are odds ratio (95% confidence interval).
