Remote Assessment of Platelet Function in Patients with Acute Stroke or Transient Ischaemic Attack
Table 1
Characteristics of patients at baseline/prerandomisation who have P-selectin data and were on antiplatelet therapy either taken before stroke or given acutely after stroke. Data are number (%), median [interquartile range], or mean (standard deviation). Comparison across all antiplatelet groups by Chi-square test, Kruskal-Wallis test, or one-way analysis of variance.
Whole trial
With P-selectin
Aspirin
Asp/Dip
Asp/Clop
Clopidogrel
None
Number
3096
689
430
50
42
54
111
Age (years)
69.0 (10.1)
68.6 (10.4)
68.9 (10.3)
70.3 (10.7)
70.5 (9.7)
68.9 (11.4)
66.3 (9.9)
0.078
Sex, male (%)
1945 (62.8)
450 (65.3)
277 (64.4)
33 (66.0)
26 (61.9)
35 (64.8)
78 (70.3)
0.81
History (%)
Hypertension
1827 (59.0)
400 (58.1)
276 (64.2)
27 (54.0)
28 (66.7)
28 (51.9)
41 (36.9)
<0.001
Hyperlipidaemia
1317 (42.5)
278 (40.3)
181 (42.1)
24 (48.0)
20 (47.6)
21 (38.9)
31 (27.9)
0.24
Diabetes
590 (19.1)
144 (20.9)
101 (23.5)
6 (12.0)
13 (31.0)
8 (14.8)
16 (14.4)
0.03
Previous stroke
349 (11.3)
67 (9.7)
32 (7.4)
15 (30.0)
10 (23.8)
7 (13.0)
3 (2.7)
<0.001
Previous TIA
337 (10.9)
68 (9.9)
36 (8.4)
17 (34.0)
4 (9.5)
10 (18.5)
1 (0.9)
<0.001
Ischaemic heart disease
403 (13.0)
71 (10.3)
51 (11.9)
7 (14.0)
5 (11.9)
4 (7.4)
3 (2.7)
0.05
Peripheral vascular disease
70 (2.3)
8 (1.2)
4 (0.9)
2 (4.0)
1 (2.4)
0 (0.0)
1 (0.9)
0.46
Smoking
Current (%)
784 (25.7)
172 (25.4)
111 (26.1)
9 (18.4)
10 (23.8)
9 (17.0)
32 (30.2)
0.32
Past (%)
1160 (38.0)
244 (36.0)
162 (38.0)
22 (44.9)
11 (26.2)
15 (28.3)
33 (31.1)
0.16
Never (%)
1108 (36.3)
262 (38.6)
153 (35.9)
18 (36.7)
21 (50.0)
29 (54.7)
41 (38.7)
0.051
Alcohol
High > 21 upw (%)
291 (9.7)
82 (12.3)
50 (11.9)
8 (17.0)
4 (10.0)
6 (11.8)
14 (13.5)
0.85
Moderate 1–21 upw (%)
1696 (56.5)
385 (57.9)
242 (57.5)
24 (51.1)
23 (57.5)
32 (62.7)
62 (59.6)
0.82
None (%)
1014 (33.8)
198 (29.8)
129 (30.6)
15 (31.9)
13 (32.5)
13 (25.5)
28 (26.9)
0.87
Index event (%)
Ischaemic stroke
2143 (69.2)
517 (75.0)
315 (73.3)
36 (72.0)
32 (76.2)
43 (79.6)
90 (81.1)
0.44
TIA
953 (30.8)
172 (25.0)
115 (26.7)
14 (28.0)
10 (23.8)
11 (20.4)
21 (18.9)
0.44
Stroke
NIHSS (/42)
3.0 [2.0, 5.0]
3.0 [2.0, 5.0]
3.0 [2.0, 5.0]
3.0 [1.5, 4.0]
3.0 [2.0, 4.5]
3.0 [2.0, 5.0]
3.0 [1.0, 5.0]
0.95
Alteplase (%)
336 (15.7)
94 (18.2)
44 (14.0)
6 (16.7)
6 (18.8)
11 (25.6)
27 (30.0)
0.0078
TIA
ABCD2 (/7)
5.0 [5.0, 6.0]
5.0 [5.0, 6.0]
5.0 [5.0, 6.0]
5.5 [5.0, 6.0]
6.0 [5.0, 7.0]
5.0 [5.0, 6.0]
6.0 [5.0, 6.0]
0.18
≥TIA in previous week (%)
183 (19.2)
27 (15.7)
15 (13.0)
4 (28.6)
4 (40.0)
2 (18.2)
2 (9.5)
0.11
TOAST (%)
Cardioembolic
133 (4.3)
29 (4.3)
20 (4.7)
0 (0.0)
3 (7.3)
1 (1.9)
5 (4.5)
0.39
Large artery
1225 (40.1)
256 (37.6)
178 (42.0)
13 (26.0)
10 (24.4)
16 (30.2)
39 (35.5)
0.029
Lacunar
490 (16.0)
130 (19.1)
68 (16.0)
15 (30.0)
9 (22.0)
16 (30.2)
21 (19.1)
0.028
Mixed
22 (0.7)
4 (0.6)
2 (0.5)
1 (2.0)
0 (0.0)
0 (0.0)
1 (0.9)
0.64
Unknown
1181 (38.6)
261 (38.4)
156 (36.8)
21 (42.0)
19 (46.3)
20 (37.7)
44 (40.0)
0.74
Systolic BP (mmHg)
143.5 (18.2)
141.8 (18.2)
142.3 (18.6)
138.4 (18.0)
139.8 (18.5)
143.7 (16.6)
141.8 (17.0)
0.52
Onset to randomisation [hrs]
29.3
29.8
29.7
30.5
32.5
30.0
29.2
0.23
Drug history (%)
In hospital
Aspirin
2197 (71.0)
463 (67.2)
398 (92.6)
40 (80.0)
25 (59.5)
0 (0.0)
0 (0.0)
<0.001
Clopidogrel
208 (6.7)
78 (11.3)
0 (0.0)
0 (0.0)
30 (71.4)
47 (87.0)
0 (0.0)
<0.001
Dipyridamole
154 (5.0)
36 (5.2)
0 (0.0)
35 (70.0)
0 (0.0)
0 (0.0)
0 (0.0)
<0.001
Antihypertensives
1742 (56.3)
383 (55.6)
262 (60.9)
28 (56.0)
29 (69.0)
26 (48.1)
37 (33.3)
<0.001
Lipid lowering
1387 (44.8)
301 (43.7)
196 (45.6)
22 (44.0)
28 (66.7)
25 (46.3)
29 (26.1)
<0.001
Diabetes medication
485 (15.7)
116 (16.8)
85 (19.8)
6 (12.0)
11 (26.2)
6 (11.1)
8 (7.2)
0.0054
Gastroprotection medication
1343 (43.4)
257 (37.3)
165 (38.4)
19 (38.0)
15 (35.7)
22 (40.7)
36 (32.4)
0.80
One patient on triple antiplatelet therapy and one patient on dipyridamole alone (protocol violations) are excluded. Protocol violation [34]; Minimisation factor used during randomisation; number (%) of those given the drug following stroke/TIA and prior to randomisation. Asp: aspirin; BP: blood pressure; Clop: clopidogrel; Dip: dipyridamole; PACS: partial anterior circulation syndrome; TACS: total anterior circulation syndrome.
