|
| Characteristic | | No diabetes |
| | All participants | Underweight/
normal weight | Overweight | Obese |
| | No. (%) | No. (%) | No. (%) | No. (%) |
|
| No. of participants a | 20246 | 5958 | 5881 | 2693 |
| No. of participants who died from all causes | 1485 | 495 | 337 | 126 |
| No. of participants who died from cardiovascular-related causes | 887 | 288 | 190 | 67 |
| Diabetes | | | | |
| No | 14532 (71.78) | | | |
| Yes | 5714 (28.22) | | | |
| BMI categories | | | | |
| Underweight/normal weight | 7864 (38.84) | | | |
| Overweight | 8138 (40.20) | | | |
| Obese | 4244 (20.96) | | | |
| BMI (kg/m2) (median, IQR) | 26.1 (23.6-29.3) | 22.9 (21.3-24.1) | 27.1 (26.0-28.3) | 32.5 (31.1-35.2) |
| Sociodemographic Characteristics | | | | |
| Age | | | | |
| ≥ 65 years | 11107 (54.86) | 3558 (59.72) | 3288 (55.91) | 1364 (50.65) |
| Gender | | | | |
| Male | 12976 (64.09) | 3843 (64.50) | 4025 (68.44) | 1450 (53.84) |
| Race/ethnicity | | | | |
| White | 11600 (57.3) | 2834 (47.57) | 3972 (67.54) | 2118 (78.65) |
| Black | 804 (3.97) | 146 (2.45) | 177 (3.01) | 149 (5.53) |
| Asian | 6645 (32.82) | 2712 (45.52) | 1416 (24.08) | 236 (8.76) |
| Hispanic | 987 (4.88) | 223 (3.74) | 271 (4.61) | 148 (5.50) |
| Other | 210 (1.04) | 43 (0.72) | 45 (0.77) | 42 (1.56) |
| Clinical Characteristics | | |
| Qualifying stroke neurological severity | |
| Mild | 18896 (93.35) | 5512 (92.53) | 5571 (94.76) | 2555 (94.88) |
| Moderate/Severe | 1347 (6.65) | 445 (7.47) | 308 (5.24) | 138 (5.11) |
| Qualifying stroke subtype | |
| Large vessel atherosclerosis | 5789 (28.61) | 1851 (31.09) | 1594 (27.12) | 639 (23.75) |
| Cardioembolic | 369 (1.82) | 111 (1.86) | 126 (2.14) | 64 (2.38) |
| Small vessel disease | 10530 (52.04) | 2999 (50.38) | 2986 (50.80) | 1399 (52.01) |
| Other | 411 (2.03) | 109 (1.83) | 133 (2.26) | 66 (2.45) |
| Unknown | 3135 (15.49) | 883 (14.83) | 1039 (17.68) | 522 (19.41) |
| Baseline systolic blood pressure (median, IQR) | 142 (130-156) | 141 (130-155) | 142 (131-156) | 143 (131-157) |
| Treatment group | |
| A † | 5024 (25.01) | 1499 (25.36) | 1464 (25.07) | 672 (25.17) |
| B ‡ | 5004 (24.91) | 1442 (24.39) | 1472 (25.21) | 680 (25.47) |
| C § | 5041 (25.09) | 1462 (24.73) | 1461 (25.02) | 636 (23.82) |
| D | | | 5019 (24.99) | 1509 (25.52) | 1442 (24.70) | 682 (25.54) |
| Risk Factors and Comorbidities | |
| History of previous stroke or TIA | |
| Yes | 4975 (24.58) | 1482 (24.89) | 1337 (22.74) | 602 (22.37) |
| History of previous myocardial infarction | |
| Yes | 1362 (6.73) | 292 (4.90) | 382 (6.50) | 199 (7.39) |
| History of atrial fibrillation | |
| Yes | 538 (2.66) | 165 (2.77) | 183 (3.11) | 89 (3.30) |
| History of congestive heart failure | |
| Yes | 532 (2.63) | 113 (1.90) | 143 (2.43) | 121 (4.49) |
| History of coronary artery disease | |
| Yes | 3296 (16.28) | 729 (12.24) | 994 (16.90) | 534 (19.83) |
| History of hypertension | |
| Yes | 14987 (74.03) | 3788 (65.58) | 4264 (72.52) | 2152 (79.91) |
| History of hyperlipidemia | |
| Yes | 9453 (46.76) | 2245 (37.73) | 2730 (46.48) | 1366 (50.89) |
| Smoking status | |
| Current smoker | 4288 (21.19) | 1682 (28.24) | 1217 (20.70) | 406 (15.09) |
| Regular alcohol consumption | |
| ≥ 1 drink/week | 7206 (35.45) | 2217 (37.22) | 2434 (41.39) | 959 (35.64) |
| Average physical activity prior to qualifying stroke | |
| Sedentary | 7209 (35.83) | 1824 (30.76) | 1865 (31.95) | 1175 (44.01) |
| Some physical activity | 6446 (32.04) | 1979 (33.37) | 1937 (33.18) | 786 (29.44) |
| Intense physical activity | 6465 (32.13) | 2127 (35.87) | 2036 (34.87) | 709 (26.55) |
|
| Characteristic | | Diabetes |
| | | Underweight/
normal weight | Overweight | Obese |
| | | No. (%) | No. (%) | No. (%) |
|
| No. of participants | | 1906 | 2257 | 1551 |
| No. of participants who died from all causes | | 219 | 180 | 128 |
| No. of participants who died from cardiovascular-related causes | | 136 | 111 | 95 |
| Diabetes | | | | |
| No | | | | |
| Yes | | | | |
| BMI categories | | | | |
| Underweight/normal-weight | | | | |
| Overweight | | | | |
| Obese | | | | |
| BMI (kg/m2) (median, IQR) | | 23.0 (21.5-24.0) | 27.2 (26.0-28.4) | 33.1 (31.3-36.3) |
| Sociodemographic Characteristics | | | | |
| Age | | | | |
| ≥ 65 years | | 1000 (52.47) | 1178 (52.19) | 719 (46.36) |
| Gender | | | | |
| Male | | 1271 (66.68) | 1530 (67.79) | 857 (55.25) |
| Race/ethnicity | | | | |
| White | | 482 (25.29) | 1106 (49.00) | 1088 (70.15) |
| Black | | 51 (2.68) | 118 (5.23) | 163 (10.51) |
| Asian | | 1277 (67.00) | 847 (37.53) | 157 (10.12) |
| Hispanic | | 82 (4.30) | 159 (7.04) | 104 (6.71) |
| Other | | 14 (0.73) | 27 (1.20) | 39 (2.51) |
| Clinical Characteristics | | | | |
| Qualifying stroke neurological severity | | |
| Mild | | 1718 (90.14) | 2083 (92.29) | 1457 (93.94) |
| Moderate/Severe | | 188 (9.86) | 174 (7.71) | 94 (6.06) |
| Qualifying stroke subtype | | | | |
| Large vessel atherosclerosis | | 663 (34.78) | 654 (28.99) | 388 (25.02) |
| Cardioembolic | | 21 (1.10) | 27 (1.20) | 20 (1.29) |
| Small vessel disease | | 1036 (54.35) | 1237 (54.83) | 873 (56.29) |
| Other | | 17 (0.89) | 41 (1.82) | 45 (2.90) |
| Unknown | | 169 (8.87) | 297 (13.16) | 225 (14.51) |
| Baseline systolic blood pressure (median, IQR) | | 142 (130-157) | 144 (132-158) | 144 (131-158) |
| Treatment group | | | | |
| A † | | 434 (22.90) | 588 (26.24) | 367 (23.97) |
| B ‡ | | 509 (26.86) | 524 (23.38) | 377 (24.62) |
| C § | | 497 (26.23) | 583 (26.02) | 402 (26.26) |
| D | | | | 455 (24.01) | 546 (24.36) | 385 (25.15) |
| Risk Factors and Comorbidities | | | | |
| History of previous stroke or TIA | | | | |
| Yes | | 547 (28.70) | 621 (27.55) | 386 (24.89) |
| History of previous myocardial infarction | | | | |
| Yes | | 105 (5.51) | 206 (9.14) | 178 (11.48) |
| History of atrial fibrillation | | | | |
| Yes | | 27 (1.42) | 34 (1.51) | 40 (2.58) |
| History of congestive heart failure | | | | |
| Yes | | 34 (1.78) | 52 (2.30) | 69 (4.45) |
| History of coronary artery disease | | | | |
| Yes | | 252 (13.22) | 433 (19.18) | 354 (22.82) |
| History of hypertension | | | | |
| Yes | | 1481 (77.70) | 1901 (84.23) | 1401 (90.33) |
| History of hyperlipidemia | | | | |
| Yes | | 882 (46.35) | 1271 (56.39) | 959 (61.91) |
| Smoking status | | | | |
| Current smoker | | 362 (18.99) | 427 (18.93) | 194 (12.52) |
| Regular alcohol consumption | | | | |
| ≥ 1 drink/week | | 467 (24.50) | 696 (30.85) | 404 (26.06) |
| Average physical activity prior to qualifying stroke | | | | |
| Sedentary | | 694 (36.70) | 896 (39.86) | 755 (48.96) |
| Some physical activity | | 592 (31.31) | 696 (30.95) | 456 (29.57) |
| Intense physical activity | | 605 (31.99) | 656 (29.18) | 331 (21.47) |
|
