Determining the Joint Effect of Obesity and Diabetes on All-Cause Mortality and Cardiovascular-Related Mortality following an Ischemic Stroke

Table 4

Adjusted HRs (95% CIs) for cardiovascular-related mortality following an ischemic stroke in relation to categorical indicators of BMI and diabetes.

Cardiovascular-Related Mortality	Obesity Categories
	Underweight/normal weight		Overweight		Obese
	Deaths/total	HR (95% CI)	Deaths/total	HR (95% CI)	Deaths/total	HR (95% CI)
Diabetes
No	288/5,598	1.00	190/5,881	0.72 (0.60, 0.88)	67/2,693	0.55 (0.41, 0.72)
Yes	136/1,906	1.53 (1.23, 1.89)	111/2,257	1.06 (0.85, 1.34)	95/1,551	1.44 (1.12, 1.86)
Interaction (additive): RERI (95% CI),			-0.187 (-0.561, 0.187),		0.372 (-0.064, 0.808)
AP † (95% CI)			-0.176 (-0.296, -0.055)		0.258 (0.155, 0.361)
Interaction on multiplicative scale: p-value			P=0.8118		P=0.0049

HRs are adjusted for age, gender, race/ethnicity, qualifying stroke neurological severity, ischemic stroke sub-type, baseline systolic blood pressure, hypertension, treatment assignment, hyperlipidemia, history of coronary artery disease, history of previous stroke or TIA, history of myocardial infarction, smoking status, and average physical activity prior to qualifying stroke.
RERI: relative excess risk due to interaction; †AP: attributable proportion due to interaction.