Science and Technology of Nuclear Installations

Volume 2014, Article ID 345252, 41 pages

http://dx.doi.org/10.1155/2014/345252

Review Article

## Generator Development: Up-to-Date Recovery Technologies for Increasing the Effectiveness of Utilisation

MEDISOTEC and CYCLOPHARM Ltd., 14(1) Dwyer Street, Gymea, NSW 2227, Australia

Received 30 June 2013; Accepted 5 August 2013; Published 16 January 2014

Academic Editor: Pablo Cristini

Copyright © 2014 Van So Le. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

#### Linked References

- P. Richards, W. D. Tucker, and S. C. Srivastava, “Technetium-99m: an historical perspective,”
*International Journal of Applied Radiation and Isotopes*, vol. 33, no. 10, pp. 793–799, 1982. View at Publisher · View at Google Scholar · View at Scopus *Non-HEU Production Technologies for Molybdenum-99 and Technetium-99m*, IAEA Nuclear Energy Series no. NF-T-5.4, International Atomic Energy Agency, Vienna, Austria, 2013.- Expert Review Panel on Medical Isotope Production,
*Report of the Expert Review Panel on Medical Isotope Production*, Ministry of Natural Resources of Canada, Ottawa, Canada, 2009. - National Research Council of the National Academies,
*Medical Isotope Production without Highly Enriched Uranium*, The National Academies Press, 2009. - OECD Nuclear Energy Agency,
*The Supply of Medical Radioisotopes: Review of Potential Molybdenum-99/Technetium-99m Production Technologies*, OECD, Paris, France, 2010. - IAEA-TECDOC-1065,
*Production Technologies for Molybdenum-99 and Technetium-99m*, International Atomic Energy Agency, Vienna, Austria, 1999. - IAEA TECDOC-515, “Fission molybdenum for medical use,” in
*Proceedings of the Technical Committee Meeting*, International Atomic Energy Agency, Karlsruhe, Germany, October 1987. - A. A. Sameh and H. J. Ache, “Production techniques of fission molybdenum-99,”
*Radiochimica Acta*, vol. 41, pp. 65–72, 1987. View at Google Scholar - H. Arino, H. H. Kramer, J. J. McGovern, and A. K. Thornton, “Production of high purity fission product molybdenum-99,” U.S. patent no. 3799883, March 1974.
- D. Novotny and G. Wagner, “Procedure of small scale production of Mo-99 on the basis of irradiated natural uranium target,” in
*Proceedings of the IAEA Consultancy Meeting on Small Scale Production of Fission Mo-99 for Use in Tc-99m Generators*, Vienna, Austria, July 2003. - A. A. Sameh and A. Bertram-Berg, “HEU and LEU as target materials for the production of fission molybdenum,” in
*Proceedings of the International Meeting on Reduced Enrichment for Research and Test Reactors*, pp. 313–333, RERTR, Roskilde, Denmark, 1992, TM19, Conf-9209266. - T. N. van der Walt and P. P. Coetzee, “The isolation of
^{99}Mo from fission material for use in the^{99}Mo/${}_{}{}^{99\text{m}}\text{T}$c generator for medical use,”*Radiochimica Acta*, vol. 92, no. 4–6, pp. 251–257, 2004. View at Publisher · View at Google Scholar · View at Scopus - A. Perkins, A. Hilson, and J. Hall, “Global shortage of medical isotopes threatens nuclear medicine services,”
*The British Medical Journal*, vol. 337, article a1577, 2008. View at Publisher · View at Google Scholar · View at Scopus - N. Ramamoorthy, “Commentary: supplies of molybdenum-99—need for sustainable strategies and enhanced international cooperation,”
*Nuclear Medicine Communications*, vol. 30, no. 12, pp. 899–905, 2009. View at Publisher · View at Google Scholar · View at Scopus - R. O. Marque's, P. R. Cristini, H. Fernandez, and D. Marziale, “Operation of the installation for fission Mo-99 production in Argentina,” IAEA-TECDOC 515, 1989.
- P. R. Cristini, H. J. Cols, R. Bavaro, M. Bronca, R. Centurio'n, and D. Cestan, “Production of molybdenum-99 from low enriched uranium targets,” in
*Proceedings of the International Meeting on Reduced Enrichment for Research and Test Reactor*, Bariloche, Argentina, November 2002. - ANSTO Media Releases, “ANSTO to help supply the world with nuclear medicine,” http://www.ansto.gov.au/AboutANSTO/News/ACSTEST_039937.
- IAEA TECDOC-1601,
*Homogeneous Aqueous Solution Nuclear Reactors for the Production of Mo-99 and Other Short Lived Radioisotopes*, International Atomic Energy Agency, Vienna, Austria, 2008. - A. J. Ziegler, D. C. Stepinski, J. F. Krebs, S. D. Chemerisov, A. J. Bakel, and G. F. Vandegrift, “Mo-99 recovery from aqueous-homogeneous-reactor fuel- behavior of termoxid sorbents,” in
*Proceedings of the International RERTR Meeting*, Washington, DC, USA, October 2008. - D. C. Stepinski, A. V. Gelis, P. Gentner, A. J. Bakel, and G. V. Vandegrift, “Evaluation of radisorb, isosorb (Thermoxid) and PZC as potential sorbents for separation of
^{99}Mo from a homogenous-reactor fuel solution,” IAEA-TECDOC-1601, September 2009. - S. Khamyanov and S. Voloshin, “A proposed international project of low-enriched uranium salt solution reactor for medical isotope production,” in
*Proceedings of the International Meeting on Reduced Enrichment for Research and Test Reactors*, Lisbon, Portugal, October 2010. - F. Stichelbaut and Y. Jongen, “
^{99}Mo production by proton-induced fission with LEU,” in*Proceedings of the CNS Workshop on the Production of Medical Radionuclides*, Ottawa, Canada, 2009. - F. Y. Tsang, “Techniques for on-demand production of medical isotopes such as Mo-99/Tc-99m and radioactive iodine isotopes including I-131,” World Intellectual Property Organization, WO, 2011/093938 A2, August 2011.
- S. Lapi, T. Ruth, and J. D'Auria, “The MoRe Project: an alternative route to the production of high specific activity
^{99}Mo,” in*Proceedings of the International Symposium on Technetium and Other Radiometals in Chemistry and Medicine*, Brixen, Italy, 2010. - A. Fong, T. I. Meyer, and K. Zala,
*Making Medical Isotopes: Final Report of the Task Force on Alternatives for Medical-Isotope Production*, TRIUMF, Vancouver, Canada, 2008. - V. S. Le, “Automated modular fission Mo-99 production process,”
*Project Proposal*, ANSTO Life Sciences, Australian Nuclear Science and Technology Organisation, 2010. View at Google Scholar - V. S. Le and C. D. Nguyen, “Separation of Tungsten from LEU fission-produced
^{99}Mo solution to improve technological performance in both the processes of^{99}Mo and ${}_{}{}^{99\text{m}}\text{T}$c generator production,” in*Proceedings of the 5th Asia-Pacific Symposium on Radiochemistry*, p. 197, Kanazawa, Japan, September 2013. - V. S. Le, “Specific radioactivity of neutron induced radioisotopes: assessment methods and application for medically useful
^{177}Lu production as a case,”*Molecules*, vol. 16, no. 1, pp. 818–846, 2011. View at Publisher · View at Google Scholar · View at Scopus - W. C. Eckelman, “Unparalleled contribution of technetium-99m to medicine over 5 decades,”
*JACC: Cardiovascular Imaging*, vol. 2, no. 3, pp. 364–368, 2009. View at Publisher · View at Google Scholar · View at Scopus - P. Gould, “Medical isotopes: time to secure supplies?”
*The Lancet Oncology*, vol. 9, no. 11, p. 1027, 2008. View at Google Scholar · View at Scopus *Technetium-99m Radiopharmaceuticals: Manufacture of Kits*, IAEA Technical Report Series no. 466, International Atomic Energy Agency, Vienna, Austria, 2008.- W. C. Eckelman and B. M. Coursey, “Technetium-99 m generators, chemistry and preparation of radio-pharmaceuticals,”
*The International Journal of Applied Radiation and Isotopes*, vol. 33, pp. 793–950, 1982. View at Google Scholar - J. J. M. de Goeij, “Routes for supply of technetium-99m for diagnostic nuclear medicine,”
*Transactions of the American Nuclear Society*, vol. 77, p. 519, 1997. View at Google Scholar - K. Bremer, “Large-scale production and distribution of Tc-99 m generators for medical use,”
*Radiochimica Acta*, vol. 41, pp. 73–81, 1987. View at Google Scholar - V. J. Molinski, “A review of ${}_{}{}^{99\text{m}}\text{T}$c generator technology,”
*International Journal of Applied Radiation and Isotopes*, vol. 33, no. 10, pp. 811–819, 1982. View at Publisher · View at Google Scholar · View at Scopus - United States Pharmacopeial Convention,
*Official Monographs: USP 28, Sodium Pertechnetate Tc*, United States Pharmacopiea (USP) 28- National Formulary (NF) 23, 2005.^{99m}Injection - British Pharmacopoeia Commission,
*British Pharmacopoeia*, The Stationery Office, Norwich, UK, 2008, http://www.pharmacopoeia.org.uk/. - C. F. Ruddock, “Purification of Technetium-99m pertechnetate solution,” U.S. patent no. 4123497, October 1978.
- P. J. Blower, “Extending the life of a ${}_{}{}^{99\text{m}}\text{T}$c generator: a simple and convenient method for concentrating generator eluate for clinical use,”
*Nuclear Medicine Communications*, vol. 14, no. 11, pp. 995–997, 1993. View at Google Scholar · View at Scopus - V. S. Le, J. McBrayer, and N. Morcos, “A radioisotope concentrator device for use with a radioisotope source, a system, and a process for capturing at least one radioisotope from a radioisotope solution obtained from a radioisotope source,” Australia patent application, AU2012904683, October 2012.
- V. S. Le, N. Morcos, J. McBrayer, Z. Bogulski, C. Buttigieg, and G. Phillips, “Disposable cartridge-based radioisotope concentrator device for increasing ${}_{}{}^{99\text{m}}\text{T}$c and
^{188}Re concentration of commercial radionuclide generator eluates,”*Journal of Labelled Compounds and Radiopharmaceuticals*, vol. 56, supplement 1, p. S190, 2013. View at Google Scholar - V. S. Le and N. Morcos, “An in-line, cartridge-based radioisotope concentrator device for use with multiple elutions from ${}_{}{}^{99\text{m}}\text{T}$c and
^{188}Re generators,”*Journal of Nuclear Medicine*, vol. 54, supplement 2, p. 609, 2013. View at Google Scholar - F. F. Knapp Jr., A. L. Beets, S. Mirzadeh, and S. Gluhlke, “Use of a new tandem cation/anion exchange system with clinical-scale generators provides high specific volume solutions of technetium-99m and rhenium-188,” IAEA-TECDOC-1029, 1998.
- F. F. Knapp, “The development and use of radionuclide generators in nuclear medicine: recent advances and future perspectives,” in
*Modern Trends in Radiopharmaceuticals for Diagnosis and Therapy*, IAEA-TECDOC-1029, pp. 485–495, International Atomic Energy Agency, Vienna, Austria, 1998. View at Google Scholar - F. F. Knapp Jr., A. L. Beets, S. Mirzadeh, and S. Guhlke, “Concentration of perrhenate and pertechnetate solutions,” U.S. patent no. 5729821, March 1998.
- S. Mirzadeh, F. F. Knapp Jr., and E. D. Collins, “A tandem radioisotope generator system for preparation of highly concentrated solutions of Tc-99m from low specific activity Mo-99,” U.S. patent no. 5774782, June 1998.
- S. K. Sarkar, G. Arjun, P. Saraswathy, and N. Ramamoorthy, “Post-elution concentration of ${}_{}{}^{99\text{m}}\text{T}$cO
_{4}^{-}by a single anion exchanger column I: feasibility of extending the useful life of column chromatographic ${}_{}{}^{99\text{m}}\text{T}$c generator,”*Applied Radiation and Isotopes*, vol. 55, no. 4, pp. 561–567, 2001. View at Publisher · View at Google Scholar · View at Scopus - S. K. Sarkar, G. Arjun, P. Saraswathy, and N. Ramamoorthy, “Post-elution concentration of (TcO
_{4}^{-})-${}_{}{}^{99\text{m}}\text{T}$c by a single anion exchanger column: II. Preparation and evaluation of jumbo alumina column chromatographic generator for ${}_{}{}^{99\text{m}}\text{T}$c,”*Nuclear Medicine Communications*, vol. 22, pp. 389–397, 2001. View at Google Scholar - S. K. Sarkar, P. Saraswathy, G. Arjun, and N. Ramamoorthy, “High radioactive concentration of ${}_{}{}^{99\text{m}}\text{T}$c from a zirconium [
^{99}Mo]molybdate gel generator using an acidic alumina column for purification and concentration,”*Nuclear Medicine Communications*, vol. 25, no. 6, pp. 609–614, 2004. View at Publisher · View at Google Scholar · View at Scopus - A. Mushtaq, “Concentration of ${}_{}{}^{99\text{m}}\text{T}$cO
_{4}^{-}/^{188}ReO_{4}^{-}by a single, compact, anion exchange cartridge,”*Nuclear Medicine Communications*, vol. 25, no. 9, pp. 957–962, 2004. View at Publisher · View at Google Scholar · View at Scopus - A. Mushtaq, “Preparation of high specific-volume solutions of technetium-99m and rhenium-188,”
*Applied Radiation and Isotopes*, vol. 58, no. 3, pp. 309–314, 2003. View at Publisher · View at Google Scholar · View at Scopus - S. Chattopadhyay and M. K. Das, “A novel technique for the effective concentration of ${}_{}{}^{99\text{m}}\text{T}$c from a large alumina column loaded with low specific-activity (n,
*γ*)-produced^{99}Mo,”*Applied Radiation and Isotopes*, vol. 66, no. 10, pp. 1295–1299, 2008. View at Publisher · View at Google Scholar · View at Scopus - S. Chattopadhyay, M. K. Das, S. K. Sarkar, P. Saraswathy, and N. Ramamoorthy, “A novel ${}_{}{}^{99\text{m}}\text{T}$c delivery system using (n,
*γ*)^{99}Mo adsorbed on a large alumina column in tandem with Dowex-1 and AgCl columns,”*Applied Radiation and Isotopes*, vol. 57, no. 1, pp. 7–16, 2002. View at Publisher · View at Google Scholar · View at Scopus - T. H. Bokhari, A. Mushtaq, and I. U. Khan, “Lead (Pb) column for concentration of ${}_{}{}^{99\text{m}}\text{T}$c-pertechnetate,”
*Radiochimica Acta*, vol. 95, no. 11, pp. 663–667, 2007. View at Publisher · View at Google Scholar · View at Scopus - S. Seifert, G. Wagner, and A. Eckardt, “Highly concentrated [${}_{}{}^{99\text{m}}\text{T}$c]pertechnetate solutions from (n,
*γ*)^{99}Mo/${}_{}{}^{99\text{m}}\text{T}$c generators for nuclear medical use,”*Applied Radiation and Isotopes*, vol. 45, no. 5, pp. 577–579, 1994. View at Publisher · View at Google Scholar · View at Scopus - R. Chakravarty, S. K. Sarkar, M. Venkatesh, and A. Dash, “An electrochemical procedure to concentrate ${}_{}{}^{99\text{m}}\text{T}$c availed from a zirconium [
^{99}Mo] molybdate gel generator,”*Applied Radiation and Isotopes*, vol. 70, no. 2, pp. 375–379, 2012. View at Publisher · View at Google Scholar · View at Scopus - V. S. Le, “Preparation of gel type chromatographic ${}_{}{}^{99\text{m}}\text{T}$c generators using Titanium and Zirconium Molybdate columns containing (n,
*γ*)Mo-99,” in*Proceedings of the IAEA Research Coordination Meeting*, Bombay, India, March 1990. - V. S. Le and M. K. Le, “Multifunctional sorbent materials and uses thereof,” Australia patent application, AU2013903629, September 2013.
- V. S. Le, “Production of ${}_{}{}^{99\text{m}}\text{T}$c isotope from chromatographic generator using zirconium-molybdate and titanium-molybdate targets as column packing materials,” in
*Proceedings of the IAEA Research Coordination Meeting*, Bandung, Indonesia, October 1987. - V. S. Le, “The radioisotope and radiopharmaceutical production in Vietnam,” in
*Proceedings of the 2nd Asian Symposium on Research Reactors (ASRR '89)*, vol. 2, pp. 1–19, Jakarta, Indonesia, May 1989. - V. S. Le, N. Morcos, J. McBrayer et al., “Development of the in-line, multiple elution cartridge -based radioisotope concentrator device for increasing ${}_{}{}^{99\text{m}}\text{T}$c and
^{188}Re concentration of commercial radionuclide generator eluates and effectiveness of^{99}Mo utilisation,” in*Proceedings of the 5th Asia-Pacific Symposium on Radiochemistry (APSORC '13)*, Kanazawa, Japan, September 2013, abstract ID 23-RPP-01. - V. S. Le, “Sorbent material,” U.S. patent application publication, US, 2013/0048568 A1, February 2013, World Intellectual Property Organization, WO, 2011/106847 A1, September 2011, Australia patent application, AU2010900902, March 2010.
- V. S. Le, “Gallium-68 purification,” U.S. patent application publication, US, 2013/0055855 A1, March 2013, World Intellectual Property Organization, WO, 2011/106846 A1, September 2011, Australia patent application, AU2010900900, March 2010.
- V. S. Le, “Gallium-68 generator integrated system: elution-purification-concentration integration,” in
*Theranostics, Gallium-68, and Other Radionuclides, Recent Results in Cancer Research 194*, R. P. Baum and F. Rösch, Eds., pp. 43–75, Springer, Berlin, Germany, 2013. View at Google Scholar - V. S. Le, “Identifying optimal conditions for the production of next generation radiopharmaceutiucals,” in
*Research Selections*, pp. 71–73, ANSTO, 2011, http://apo.ansto.gov.au/dspace/handle/10238/3886. View at Google Scholar - T. Genka, “Needs and current status of Mo-99/Tc-99m production in Japan,” in
*Proceedings of the Meeting on Mo-99 Production by (n,γ) Method*, Tokyo, Japan, March 2012. - A. Mushtaq, “Producing radioisotopes in power reactor,”
*Journal of Radioanalytical and Nuclear Chemistry*, vol. 292, pp. 793–802, 2012. View at Google Scholar - V. S. Le, “Utilisation of nuclear research reactor in Vietnam,” in
*Proceedings of the IAEA Advisory Group Meeting on Optimisation of Research Reactor Utilisation for Production of Radioisotopes*, JAERI, Tokai-Mura, Japan, October 1995. - V. S. Le, “Development of alternative technologies for a gel-type chromatographic ${}_{}{}^{99\text{m}}\text{T}$c generator,” in
*Proceedings of the IAEA Research Coordination Meeting*, Vienna, Austria, May 1994. - IAEA-TECDOC-852,
*Alternative Technologies for*, International Atomic Energy Agency, Vienna, Austria, 1995.^{99m}Tc Generators - K. Tsuchiya, “Atatus of
^{99}Mo-${}_{}{}^{99\text{m}}\text{T}$c production development by (n,*γ*) reaction in Japan,” in*Proceedings of the Specialist Meeting on Mo-99 Production by (n,γ) Method*, Tokyo, Japan, March 2012. - E. Ishitsuka and K. Tatenuma, “Process for producing radioactive molybdenum,” World Intellectual Property Organization, WO, 2008/047946, April 2008.
- B. J. Jun, M. Tanimotor, A. Kimura, N. Hori, H. Izumo, and K. Tsuchiya, “Feasibility study on mass production of (n,
*γ*)^{99}Mo,”*JAEA-Research Report*2010-046, Japan Atomic Energy Agency, 2011. View at Google Scholar - Y. Inaba, K. Iimura, J. Hosokawa, H. Izumo, N. Hori, and E. Ishitsuka, “Status of development on
^{99}Mo production technologies in JMTR,”*IEEE Transactions on Nuclear Science*, vol. 58, no. 3, pp. 1151–1158, 2011. View at Publisher · View at Google Scholar · View at Scopus - C. Ross, R. Galea, P. Small et al., “Using the
^{100}Mo photonuclear reaction to meet Canada's requirement for ${}_{}{}^{99\text{m}}\text{T}$c,”*Physics in Canada*, vol. 66, pp. 19–24, 2010. View at Google Scholar - M. C. Lagunas-Solar, P. M. Kiefer, O. F. Carvacho, C. A. Lagunas, and Y. P. Cha, “Cyclotron production of NCA ${}_{}{}^{99\text{m}}\text{T}$c and
^{99}Mo. An alternative non-reactor supply source of instant ${}_{}{}^{99\text{m}}\text{T}$c and^{99}Mo → ${}_{}{}^{99\text{m}}\text{T}$c generators,”*Applied Radiation and Isotopes*, vol. 42, no. 7, pp. 643–657, 1991. View at Publisher · View at Google Scholar · View at Scopus - M. C. Lagunas-Solar, “Accelerator production of ${}_{}{}^{99\text{m}}\text{T}$c with proton beams and enriched
^{100}Mo targets,” in*IAEA-TECDOC-1065, Production Technologies for Molybdenum-99 and Technetium-99m*, International Atomic Energy Agency, Vienna, Austria, 1999. View at Google Scholar - B. Scholten, R. M. Lambrecht, M. Cogneau, H. V. Ruiz, and S. M. Qaim, “Excitation functions for the cyclotron production of ${}_{}{}^{99\text{m}}\text{T}$c and
^{99}Mo,”*Applied Radiation and Isotopes*, vol. 51, no. 1, pp. 69–80, 1999. View at Publisher · View at Google Scholar · View at Scopus - S. Takács, Z. Szücs, F. Tárkányi, A. Hermanne, and M. Sonckz, “Evaluation of proton induced reactions on
^{100}Mo: new cross sections for production of ${}_{}{}^{99\text{m}}\text{T}$c and^{99}Mo,”*Journal of Radioanalytical and Nuclear Chemistry*, vol. 257, no. 1, pp. 195–201, 2003. View at Publisher · View at Google Scholar · View at Scopus - Y. Nagai and Y. Hatsukawa, “Production of
^{99}Mo for nuclear medicine by^{100}Mo(n, 2n)^{99}Mo,”*Journal of the Physical Society of Japan*, vol. 78, no. 3, Article ID 033201, 2009. View at Publisher · View at Google Scholar · View at Scopus - J. E. Beaver and H. B. Hupf, “Production of ${}_{}{}^{99\text{m}}\text{T}$c on a medical cyclotron: a feasibility study,”
*Journal of Nuclear Medicine*, vol. 12, no. 11, pp. 739–741, 1971. View at Google Scholar · View at Scopus - M. B. Challan, M. N. H. Comsan, and M. A. Abou-Zeid, “Thin target yields and Empire: II. predictions on the accelerator production of technetium-99m,”
*Journal of Nuclear and Radiation Physics*, vol. 2, no. 1, pp. 1–12, 2007. View at Google Scholar - K. Gagnon, F. Bénard, M. Kovacs et al., “Cyclotron production of ${}_{}{}^{99\text{m}}\text{T}$c: experimental measurement of the
^{100}Mo(p,x)^{99}Mo,${}_{}{}^{99\text{m}}\text{T}$c and ${}_{}{}^{99\text{g}}\text{T}$c excitation functions from 8 to 18 MeV,”*Nuclear Medicine and Biology*, vol. 38, no. 6, pp. 907–916, 2011. View at Publisher · View at Google Scholar · View at Scopus - H. T. Wolterbeek and P. Bode, “A process for the production of no-carrier added
^{99}Mo,” European Patents EP, 2131369 (A1), December 2009, Worldwide Patent 2009148306, December 2009, EP, 2301041 (A1), March 2011, U.S. patent US, 2011118491 (A1), May 2011. - B. S. Tomar, O. M. Steinebach, B. E. Terpstra, P. Bode, and H. T. Wolterbeek, “Studies on production of high specific activity
^{99}Mo and^{90}Y by Szilard Chalmers reaction,”*Radiochimica Acta*, vol. 98, no. 8, pp. 499–506, 2010. View at Publisher · View at Google Scholar · View at Scopus - T. J. Ruth, “Two routes to solving the Mo/Tc isotope crisis: direct production of ${}_{}{}^{99\text{m}}\text{T}$c and isotope separation,” in
*Proceedings of the CNS Workshop on the Production of Medical Radionuclides*, Ottawa, Canada, 2009. - E. P. Belkas and D. C. Perricos, “Technetium-99m production based on the extraction with methyl-ethyl ketone,”
*Radiochimica Acta*, vol. 11, p. 56, 1969. View at Google Scholar - G. D. Robinson, “A simple manual system for the efficient, routine production of ${}_{}{}^{99\text{m}}\text{T}$c
by methyl-ethyl-ketone extraction,”
*Journal of Nuclear Medicine*, vol. 12, p. 459, 1971. View at Google Scholar - M. P. Zykov, V. N. Romanovskii, D. W. Wester et al., “Use of extraction generator for preparing a ${}_{}{}^{99\text{m}}\text{T}$c radiopharmaceutical,”
*Radiochemistry*, vol. 43, no. 3, pp. 297–300, 2001. View at Google Scholar - T. le Minh and T. Lengyel, “On the separation of molybdenum and technetium crown ether as extraction agent,”
*Journal of Radioanalytical and Nuclear Chemistry Letters*, vol. 135, no. 6, pp. 403–407, 1989. View at Publisher · View at Google Scholar · View at Scopus - M. Maiti and S. Lahiri, “Separation of
^{99}Mo and ${}_{}{}^{99\text{m}}\text{T}$c by liquid-liquid extraction using trioctylamine as extractant,”*Journal of Radioanalytical and Nuclear Chemistry*, vol. 283, no. 3, pp. 661–663, 2010. View at Publisher · View at Google Scholar · View at Scopus - R. E. Boyd, “Technetium-99m generators—the available options,”
*International Journal of Applied Radiation and Isotopes*, vol. 33, no. 10, pp. 801–809, 1982. View at Publisher · View at Google Scholar · View at Scopus - K. Svoboda, “Survey of solvent extraction ${}_{}{}^{99\text{m}}\text{T}$c-generator technologies,”
*Radiochimica Acta*, vol. 41, pp. 83–89, 1987. View at Google Scholar - “Radionuclide generator technology,”
*Radiochimica Acta*, vol. 41, no. 2-3, 1987. - A. A. Kuznetsov, A. A. Kudrin, and G. E. Kodina, “Semi-automatic ${}_{}{}^{99\text{m}}\text{T}$c solvent extraction system,” in
*Proceedings of the 7th International Symposium on Technetium and Rhenium-Science and Utilization*, Moscow, Russia, July 2011, abstract book 4.P13. - E. Taskaev, M. Taskaeva, and P. Nikolov, “Extraction generator for [${}_{}{}^{99\text{m}}\text{T}$c]sodium pertechnetate production,”
*Applied Radiation and Isotopes*, vol. 46, no. 1, pp. 13–16, 1995. View at Publisher · View at Google Scholar · View at Scopus - O. P. D. Noronha, “Solvent extraction technology of
^{99}Mo-${}_{}{}^{99\text{m}}\text{T}$c generator system,” in*Proceedings of the Conference on Radiopharmaceuticals and Labelled Compounds*, Tokyo, Japan, 1984. - Y. N. Reshetnik, A. N. Bykov, G. E. Kodina, and A. O. Malysheva, “Sorption removal of Na ${}_{}{}^{99\text{m}}\text{T}$cO
_{4}from extracts of extraction generator^{99}Mo/${}_{}{}^{99\text{m}}\text{T}$c,” in*Proceedings of the 7th International Symposium on Technetium and Rhenium-Science and Utilization*, Moscow, Russia, July 2011, abstract book 4.P12. - S. Chattopadhyay, S. S. Das, and L. Barua, “A simple and rapid technique for recovery of ${}_{}{}^{99\text{m}}\text{T}$c from low specific activity (n,
*γ*)^{99}Mo based on solvent extraction and column chromatography,”*Applied Radiation and Isotopes*, vol. 68, no. 1, pp. 1–4, 2010. View at Publisher · View at Google Scholar · View at Scopus - S. Chattopadhyay, L. Barua, A. De et al., “A computerized compact module for separation of ${}_{}{}^{99\text{m}}\text{T}$c-radionuclide from molybdenum,”
*Applied Radiation and Isotopes*, vol. 70, no. 11, pp. 2631–2637, 2012. View at Publisher · View at Google Scholar - M. Tanase, A. Kimura, Y. Morikawa et al., “R&D in on extraction and concentration of ${}_{}{}^{99\text{m}}\text{T}$c: a preliminary study using Re instead of ${}_{}{}^{99\text{m}}\text{T}$c,” in
*Proceedings of the Specialist Meeting on Mo-99 Production by (n,γ) Method*, Tokyo, Japan, March 2012. - S. Tachimori, H. Amano, and H. Nakamura, “Preparation of Tc-99m by direct adsorption from organic solution,”
*Journal of Nuclear Science and Technology*, vol. 8, pp. 357–362, 1971. View at Google Scholar - V. S. Le, “${}_{}{}^{99\text{m}}\text{T}$c generator preparation using (n,
*γ*)^{99}Mo produced ex-natural molybdenum,” in*Proceedings of the FNCA Workshop on the Utilization of Research Reactors*, pp. 216–223, Japan Atomic Energy Research Institute, 2003, JAERI-Conf 2003-004. - V. S. Le and R. M. Lambrecht, “Development of alternative technologies for a gel-type chromatographic ${}_{}{}^{99\text{m}}\text{T}$c generator,”
*Journal of Labelled Compounds and Radiopharmaceuticals*, vol. 35, pp. 270–272, 1994. View at Google Scholar · View at Scopus - V. S. Le, “Recent progress in radioisotope production in Vietnam,” in
*Proceedings of the Workshop on the Utilization of Research Reactors*, pp. 308–314, Japan Atomic Energy Research Institute, 1998, JAERI-conf 98-015. - V. S. Le, “Preparation of chromatographic and solid-solvent extraction ${}_{}{}^{99\text{m}}\text{T}$c generator using gel-type targets,” in
*Proceedings of the Workshop on the Utilization of Research Reactors*, pp. 187–192, Japan Atomic Energy Research Institute, 2000, JAERI-conf 2000-017. - T. Genka, “Development of PZC-based Tc-99m Generator,” Forum for Nuclear Cooperation in Asia (FNCA), no. 2, March 2007.
- V. S. Le, “Procedures for the production of poly-zirconium-compound (PZC) based chromatographic ${}_{}{}^{99\text{m}}\text{T}$c generator to be available for clinical application,” in
*Proceedings of the FNCA Workshop on the Utilization of Research Reactors*, pp. 229–256, Japan Atomic Energy Agency, 2006, JAEA-Conf 2006-001. - V. S. Le, C. D. Nguyen, P. Pellegrini, and V. C. Bui, “Polymeric titanium oxychloride sorbent for
^{188}W/^{188}Re nuclide pair separation,”*Separation Science and Technology*, vol. 44, no. 5, pp. 1074–1098, 2009. View at Publisher · View at Google Scholar · View at Scopus - V. S. Le, “Medical radioisotope development, radionuclide development group, project no. RRI-0168,”
*Report at ANSTO's Board Review Panel*, ANSTO, 2009. View at Google Scholar - V. S. Le, “
^{68}Ga PET-radionuclide generator development,” in*Proceedings of the Seminar on Radiopharmaceutical Development*, Radiopharmaceutical Research Institute, ANSTO, June 2009. - R. E. Boyd, “
^{99}Mo/${}_{}{}^{99\text{m}}\text{T}$c generator,”*Radiochimica Acta*, vol. 30, no. 3, pp. 123–146, 1982. View at Google Scholar - R. E. Boyd, “Technetium generators—status and prospects,”
*Radiochimica Acta*, vol. 41, no. 2-3, pp. 59–63, 1987. View at Google Scholar - J. Gerse, J. Kern, J. Imre, and L. Zsinka, “Examination of a portable
^{99}Mo/${}_{}{}^{99\text{m}}\text{T}$c isotope generator /SUBLITECH(R)/,”*Journal of Radioanalytical and Nuclear Chemistry*, vol. 128, no. 1, pp. 71–80, 1988. View at Google Scholar · View at Scopus - L. Zsinka, “${}_{}{}^{99\text{m}}\text{T}$c sublimation generators,”
*Radiochimica Acta*, vol. 41, pp. 91–96, 1987. View at Google Scholar - F. Rösch, A. F. Novgorodov, and S. M. Qaim, “Thermochromatographic separation of ${}_{}{}^{94\text{m}}\text{T}$c
from enriched molybdenum targets and its large scale production for nuclear medical application,”
*Radiochimica Acta*, vol. 64, pp. 113–120, 1994. View at Google Scholar - R. Chakravarty, M. Venkatesh, and A. Dash, “A novel electrochemical
^{99}Mo/${}_{}{}^{99\text{m}}\text{T}$c generator,”*Journal of Radioanalytical and Nuclear Chemistry*, vol. 290, no. 1, pp. 45–51, 2011. View at Publisher · View at Google Scholar · View at Scopus - R. Chakravarty, A. Dash, and M. Venkatesh, “A novel electrochemical technique for the production of clinical grade ${}_{}{}^{99\text{m}}\text{T}$c using (n,
*γ*)^{99}Mo,”*Nuclear Medicine and Biology*, vol. 37, no. 1, pp. 21–28, 2010. View at Publisher · View at Google Scholar · View at Scopus - K. Tagami and S. Uchida, “Elution behavior of Tc and Re through a Tc-selective chromatographic resin column,”
*Journal of Radioanalytical and Nuclear Chemistry*, vol. 239, p. 643, 1999. View at Google Scholar - X. Hou, M. Jensen, and S. Nielsen, “Use of ${}_{}{}^{99\text{m}}\text{T}$c from a commercial
^{99}Mo/${}_{}{}^{99\text{m}}\text{T}$c generator as yield tracer for the determination of^{99}Tc at low levels,”*Applied Radiation and Isotopes*, vol. 65, no. 5, pp. 610–618, 2007. View at Publisher · View at Google Scholar - M. Fikrle, J. Kučera, and F. Šebesta, “Preparation of ${}_{}{}^{95\text{m}}\text{T}$c radiotracer,”
*Journal of Radioanalytical and Nuclear Chemistry*, vol. 286, no. 3, pp. 661–663, 2010. View at Publisher · View at Google Scholar · View at Scopus - A. Bartosova, P. Rajec, and M. Reich, “Preparation and characterization of an extraction chromatography column for technetium separation based on Aliquat-336 and silica gel support,”
*Journal of Radioanalytical and Nuclear Chemistry*, vol. 261, no. 1, pp. 119–124, 2004. View at Publisher · View at Google Scholar · View at Scopus - E. Akatsu, R. Ono, K. Tsukuechi, and H. Uchiyama, “Radiochemical study of adsorption behavior of inorganic ions on zirconium-phosphate, silica gel and charcoal,”
*Journal of Nuclear Science and Technology*, vol. 2, pp. 141–148, 1965. View at Google Scholar - R. Rogers, P. E. Horwitz, and A. H. Bond, “Process for recovering pertechnetate ions from an aqueous solution also containing other ions,” U.S. patent no. 5603834, February 1997.
- S. Chattopadhyay, S. S. Das, M. K. Das, and N. C. Goomer, “Recovery of ${}_{}{}^{99\text{m}}\text{T}$c from Na
_{2}[^{99}Mo]MoO_{4}solution obtained from reactor-produced (n,*γ*)^{99}Mo using a tiny Dowex-1 column in tandem with a small alumina column,”*Applied Radiation and Isotopes*, vol. 66, no. 12, pp. 1814–1817, 2008. View at Publisher · View at Google Scholar · View at Scopus - R. D. Rogers, A. H. Bond, J. Zhang, and E. Philip Horwitz, “New technetium-99m generator technologies utilizing polyethylene glycol-based aqueous biphasic systems,”
*Separation Science and Technology*, vol. 32, no. 1–4, pp. 867–882, 1997. View at Google Scholar · View at Scopus - S. K. Spear, S. T. Griffin, J. G. Huddleston, and R. D. Rogers, “Radiopharmaceutical and hydrometallurgical separations of perrhenate using aqueous biphasic systems and the analogous aqueous biphasic extraction chromatographic resins,”
*Industrial and Engineering Chemistry Research*, vol. 39, no. 9, pp. 3173–3180, 2000. View at Google Scholar · View at Scopus - J. E. Young and J. J. Hines, “Compact automated radionuclide separator,” U.S. patent no. 6770195, August 2004.
- H. Bond, J. J. Hines, J. E. Young, and E. P. Horwitz, “Automated radionuclide separation system and method,” U.S. patent no. 67870427, September 2004.
- E. P. Horwitz and A. H. Bond, “Multicolumn selectivity inversion generator for production of ultrapure radionuclides,” U.S. patent no. 6998052, February 2006.
- D. R. McAlister and E. P. Horwitz, “Automated two column generator systems for medical radionuclides,”
*Applied Radiation and Isotopes*, vol. 67, no. 11, pp. 1985–1991, 2009. View at Publisher · View at Google Scholar · View at Scopus - V. S. Le, “Development of alternative technologies for a gel-type chromatographic ${}_{}{}^{99\text{m}}\text{T}$c generator,” IAEA-TECDOC 852, December 1995.
- J. J. Pinajian, “A technetium-99m generator using hydrous zirconium oxide,”
*The International Journal of Applied Radiation and Isotopes*, vol. 17, no. 11-12, pp. 664–670, 1966. View at Google Scholar · View at Scopus - Q. M. Qazi and A. Mushtaq, “Preparation and evaluation of hydrous titanium oxide as a high affinity adsorbent for molybdenum (
^{99}Mo) and its potential for use in ${}_{}{}^{99\text{m}}\text{T}$c generators,”*Radiochimica Acta*, vol. 99, no. 4, pp. 231–235, 2011. View at Publisher · View at Google Scholar · View at Scopus - S. Meloni and A. Brandone, “A new technetium-99m generator using manganese dioxide,”
*The International Journal of Applied Radiation and Isotopes*, vol. 19, no. 2, pp. 164–166, 1968. View at Google Scholar · View at Scopus - J. Serrano Gómez and F. Granados Correa, “${}_{}{}^{99\text{m}}\text{T}$c generator with hydrated MnO
_{2}as adsorbent of^{99}Mo,”*Journal of Radioanalytical and Nuclear Chemistry*, vol. 254, no. 3, pp. 625–628, 2002. View at Publisher · View at Google Scholar · View at Scopus - Y. Maki and Y. Murakami, “${}_{}{}^{99\text{m}}\text{T}$c generator by use of silica gel as adsorbent,”
*Nipon Kagaku Zasshi*, vol. 92, pp. 1211–1212, 1971. View at Google Scholar - J. Serrano, H. González, H. López, N. Aranda, F. Granados, and S. Bulbulian, “Sorption of
^{99}Mo${{\text{O}}_{4}}^{2-}$ ions on commercial hydrotalcites,”*Radiochimica Acta*, vol. 93, no. 9-10, pp. 605–609, 2005. View at Publisher · View at Google Scholar · View at Scopus - V. S. Le,
*Investigation on inorganic ion exchangers supported on silica matrix [Ph.D. thesis]*, Isotope Institute, Hungarian Academy of Sciences, 1985. - F. Monroy-Guzman, V. E. Badillo Almaraz, J. A. Flores de la Torre, J. Cosgrove, and F. F. Knapp Jr., “Hydroxyapatite-based
^{99}Mo/${}_{}{}^{99\text{m}}\text{T}$c and^{188}W/^{188}Re generator systems,” in*Trends in Radiopharmaceutical (ISTR-2005)*, vol. 1, IAEA, Vienna, Austria, 2007. View at Google Scholar - T. Braun, H. Imura, and N. Suzuki, “Separation of ${}_{}{}^{99\text{m}}\text{T}$c from parent
^{99}Mo by solid-phase column extraction as a simple option for a new ${}_{}{}^{99\text{m}}\text{T}$c generator concept,”*Journal of Radioanalytical and Nuclear Chemistry Letters*, vol. 119, no. 4, pp. 315–325, 1987. View at Publisher · View at Google Scholar · View at Scopus - V. S. Le, “Study on the titanium- and zirconium-molybdate gel-type ${}_{}{}^{99\text{m}}\text{T}$c generators,”
*Annual Report*, Vietnam Atomic Energy Committee, 1984. View at Google Scholar - J. V. Evans, P. W. Moore, M. E. Shying, and J. M. Sodeau, “Zirconium molybdate gel as a generator for technetium-99m—I. The concept and its evaluation,”
*International Journal of Radiation Applications and Instrumentation A*, vol. 38, no. 1, pp. 19–23, 1987. View at Google Scholar · View at Scopus - P. W. Moore, M. E. Shying, J. M. Sodeau, J. V. Evans, D. J. Maddalena, and K. H. Farrington, “Zirconium molybdate gel as a generator for technetium-99m—II. High activity generators,”
*International Journal of Radiation Applications and Instrumentation A*, vol. 38, no. 1, pp. 25–29, 1987. View at Google Scholar · View at Scopus - R. E. Boyd, “The gel generator: a viable alternative source of ${}_{}{}^{99\text{m}}\text{T}$c for nuclear medicine,”
*Applied Radiation and Isotopes*, vol. 48, no. 8, pp. 1027–1033, 1997. View at Publisher · View at Google Scholar · View at Scopus - V. S. Le, “Development of alternative technologies for a gel-type chromatographic ${}_{}{}^{99\text{m}}\text{T}$c generator,” in
*Proceedings of the IAEA Research Coordination Meeting*, Budapest, Hungary, February 1993. - J. A. Osso Junior, A. L. V. P. Lima, N. C. da Silva, R. C. Nieto, and A. C. de Velosa, “Preparation of a gel of zirconium molybdate for use in the generators of
^{99}Mo—${}_{}{}^{99\text{m}}\text{T}$c prepared with^{99}Mo produced by the^{98}Mo(n,*γ*)^{99}Mo reaction,” in*Proceedings of the International Meeting on Reduced Enrichment for Research and Test Reactors*, San Paulo, Brazil, October 1998. - V. S. Le, “Investigation on the performance of polymer zirconium compound (PZC) for chromatographic ${}_{}{}^{99\text{m}}\text{T}$c generator preparation,” in
*Proceedings of the FNCA Workshop on the Utilization of Research Reactors*, pp. 90–104, Japan Atomic Energy Research Institute, 2004, JAERI-Conf 2004-010. - Y. Hasegawa, M. Nishino, T. Takeuch et al., “Mo adsorbent for
^{99}Mo-${}_{}{}^{99\text{m}}\text{T}$c generators and manufacturing thereof,” US patent no. 5681974, October 1997. - M. Tanase, K. Tatenuma, K. Ishikawa, K. Kurosawa, M. Nishino, and Y. Hasegawa, “A ${}_{}{}^{99\text{m}}\text{T}$c generator using a new inorganic polymer adsorbent for (n,
*γ*)^{99}Mo,”*Applied Radiation and Isotopes*, vol. 48, no. 5, pp. 607–611, 1997. View at Publisher · View at Google Scholar · View at Scopus - V. S. Le, “Preparation of PZC based ${}_{}{}^{99\text{m}}\text{T}$c generator to be available for clinical application,” in
*Proceedings of the IAEA Research Coordination Meeting on Development of Generator Technologies for Therapeutic Radionuclides*, ANSTO, Vienna, Austria, October 2004, http://apo.ansto.gov.au/dspace/handle/10238/3713. - V. S. Le, “Chemical synthesis and application of zirconium and titanium polymer compounds for the preparation of Tc-99m and Re-188 chromatographic generators,” in
*Proceedings of the 2nd Research Coordination Meeting on Development of Generator Technologies for Therapeutic Radionuclides*, ANSTO, Milan, Italy, April 2006, http://apo.ansto.gov.au/dspace/handle/10238/3714. - V. S. Le, C. D. Nguyen, V. C. Bui, and C. H. Vo, “Synthesis, characterization and application of PTC and PZC sorbents for preparation of chromatographic ${}_{}{}^{99\text{m}}\text{T}$c and
^{188}Re generators,” in*Proceedings of the IAEA Research Coordination Meeting on Development of Generator Technologies for Therapeutic Radionuclides*, ANSTO, Daejeon, Republic of Korea, October 2007, http://apo.ansto.gov.au/dspace/handle/10238/3715. - V. S. Le, C. D. Nguyen, V. C. Bui, and C. H. Vo, “Preparation of inorganic polymer sorbents and their application in radionuclide generator technology,” in
*Therapeutic Radionuclide Generators:*, IAEA Technical Report Series no. 470, chapter 20, International Atomic Energy Agency, Vienna, Austria, 2009. View at Google Scholar^{90}Sr/^{90}Y and^{188}W/^{188}Re Generators - M. Asif and A. Mushtaq, “Evaluation of highly loaded low specific activity
^{99}Mo on alumina column as ${}_{}{}^{99\text{m}}\text{T}$c generator,”*Journal of Radioanalytical and Nuclear Chemistry*, vol. 284, no. 2, pp. 439–442, 2010. View at Publisher · View at Google Scholar · View at Scopus - J. S. Lee, H. S. Han, U. J. Park et al., “Adsorbents for radioisotopes, preparation method thereof, and radioisotope generators using the same,” U.S. patent application publication, US, 2009/0277828 A1, November 2009.
- A. Mushtaq, “Inorganic ion-exchangers: their role in chromatographic radionuclide generators for the decade 1993–2002,”
*Journal of Radioanalytical and Nuclear Chemistry*, vol. 262, no. 3, pp. 797–810, 2004. View at Publisher · View at Google Scholar · View at Scopus - V. S. Le, M. Izard, P. Pellegrini, and M. Zaw, “Development of
^{68}Ga generator at ANSTO,” in*Proceedings of the 1st World Congress on Ga-68 and Peptide Receptor Radionuclide Therapy (THERANOSTICS '11)*, ANSTO, Bad Berka, Germany, June 2011, World Journal of Nuclear Medicine, vol. 10, no. 1, pp. 73–89, P-023, http://apo.ansto.gov.au/dspace/handle/10238/3701. - R. Chakravarty, R. Shukla, S. Gandhi et al., “Polymer embedded nanocrystalline titania sorbent for
^{99}Mo-${}_{}{}^{99\text{m}}\text{T}$c generator,”*Journal of Nanoscience and Nanotechnology*, vol. 8, no. 9, pp. 4447–4452, 2008. View at Publisher · View at Google Scholar · View at Scopus - R. Chakravarty, R. R. Shukla, R. Ram, A. K. Tyagi, A. Das, and M. Venkatesh, “Nanocrystalline zircona: a new sorbent for the preparation of
^{99}Mo-${}_{}{}^{99\text{m}}\text{T}$c generators,”*Journal of Labelled Compounds and Radiopharmaceuticals*, vol. 52, supplement 1, p. S500, 2009. View at Google Scholar - R. Chakravarty,
*Development of radionuclide generator for biomedical applications [Ph.D. thesis]*, Homi Bhabha National Institute, 2011. - J. V. Evans and R. W. Matthews, “Technetium-99m generators,” U.S. patent no. 4280053, July 1981.
- V. H. Tran and V. S. Le, “Activation analysis of trace elements in titanium-molybdate gel target used for pre-formed TiMo-gel-based ${}_{}{}^{99\text{m}}\text{T}$c generator production and radionuclidic impurity of ${}_{}{}^{99\text{m}}\text{T}$c pertechnetate eluate,” in
*Proceedings of the FNCA Workshop on the Utilization of Research Reactors*, pp. 105–111, Japan Atomic Energy Research Institute, June 2004, JAERI-Conf 2004-010. - R. Chakravarty, R. Ram, R. Mishra et al., “Mesoporous Alumina (MA) based double column approach for development of a clinical scale
^{99}Mo/${}_{}{}^{99\text{m}}\text{T}$c generator using (n,*γ*)^{99}Mo: an enticing application of nanomaterial,”*Industrial & Engineering Chemistry Research*, vol. 52, no. 33, pp. 11673–11684, 2013. View at Publisher · View at Google Scholar - A. Dash, F. F. (Russ) Knapp Jr., and M. R. A. Pillaia, “
^{99}Mo/${}_{}{}^{99\text{m}}\text{T}$c separation: an assessment of technology options,”*Nuclear Medicine and Biology*, vol. 40, no. 2, pp. 167–176, 2013. View at Google Scholar - V. S. Le and N. Morcos, “New SPE column packing material: retention assessment method and its application for the radionuclide chromatographic separation,”
*Journal of Radioanalytical and Nuclear Chemistry*, vol. 277, no. 3, pp. 651–661, 2008. View at Publisher · View at Google Scholar · View at Scopus - I. Zolle, Ed.,
*Technetium-99m Radiopharmaceuticals: Preparation and Quality Control in Nuclear Medicine*, Springer, Berlin, Germany, 2007.