Genomic Characterization and Pathogenicity of BJEU06-1-Like PRRSV-1 ZD-1 Isolated in China

Table 2

Comparison of pathogenicity of different PRRSV-1 strains.

Infected PRRSV strain	Subtype	Country	The days of inoculation (dpi)	Inoculated dose	Parameters of evaluation	Challenge group	Reference
ZD-1	Subtype 1	China	21	4 × 10^4 TCID50	Clinical symptoms	Medium clinical symptoms	This study
					Days of fever	6 days (≥40.0°C)
					Pathological and histopathological lesions	Obvious pathological changes
					Viremia	Peaked at 7 dpi, longer than 21 days
HLJB1	Subtype 1	China	14	1 × 10^5 TCID50	Clinical symptoms	Severe clinical symptoms, 3/7 pigs died	[16]
					Days of fever	3 days (≥40°C)
					Pathological and histopathological lesions	Obvious pathological changes
					Viremia	Peaked at 7 dpi, longer than 21 days
GZ11-G1	Subtype 1	China	21	2 × 10^5 TCID50	Clinical symptoms	Mild clinical symptoms	[17]
					Days of fever	3 days (≥40.0°C)
					Pathological and histopathological lesions	Mild pathological changes
					Viremia	Peaked at 7 dpi, longer than 21 days
PR40/2014	Subtype 1	Italy	35	1 × 10^5 TCID50	Clinical symptoms	Severe clinical symptoms, 3/7 pigs died	[49]
					Days of fever	19 days (≥40°C)
					Pathological and histopathological lesions	Severe pathological changes
					Viremia	Peaked at 7 dpi, longer than 35 days
WestSib13	Subtype 2	Russia	14	5 × 10^4.7 TCID50	Clinical symptoms	Severe clinical symptoms, 5/5 pigs died	[52]
					Days of fever	No fever
					Pathological and histopathological lesions	Severe pathological changes
					Viremia	Peaked at 6 dpi, all pigs died seven days after infection
Lena	Subtype 3	Belarusian	21	1 × 10^6 TCID50	Clinical symptoms	Severe clinical symptoms, 4/10 pigs died	[45]
					Days of fever	25 days (≥40°C)
					Pathological and histopathological lesions	Severe pathological changes
					Viremia	Peaked at 14 dpi, longer than 35 days