|
Site | Score | Description |
|
Joints |
|
Cartilage | 0 | Normal |
1 | Minimal focal or multifocal erosion of the most superficial layer of cells of articular cartilage |
2 | Mild focal or multifocal erosion (5–6 cell layers thick) |
3 | Moderate focal or multifocal erosion one-fourth or more of thickness of articular cartilage |
4 | Marked focal or multifocal erosion extending to subchondral bone |
|
Subchondral bone | 0 | Normal |
1 | Minimal evidence of osteoclast remodeling only |
2 | Mild fibrous proliferation within marrow cavity and osteoclast remodeling |
3 | Moderate fibrous proliferation throughout marrow cavity and osteoclast remodeling |
4 | Marked destruction of bone with osteonecrosis and osteomyelitis |
|
Exudate in joint spaces | 0 | None |
1 | Minimal (rare) granulocytes and mononuclear cells |
2 | Mild accumulations of granulocytes, mononuclear cells, fibrin, and necrotic debris |
3 | Moderate accumulations of granulocytes, mononuclear cells, fibrin, and necrotic debris |
4 | Marked accumulations of granulocytes, mononuclear cells, fibrin, and necrotic debris |
|
Synovium/fibrous capsule | 0 | Normal |
1 | Minimal (rare to occasional) granulocytes and macrophages in synovium/fibrous capsule |
2 | Mild accumulations of scattered granulocytes and macrophages in synovium/fibrous capsule |
3 | Moderate, dense accumulations of granulocytes, and macrophages limited to fibrous capsule ± edema |
4 | Marked destruction of fibrous capsule with infiltration into adjacent soft tissues |
|
Brain |
|
Meningitis | 0 | No lesions |
1 | Mild focal meningitis |
2 | Moderate focal or mild to moderate multifocal meningitis |
3 | Focal granulomas associated with meninges |
4 | Severe focal or moderate to severe multifocal meningitis |
|
Encephalitis | 0 | No lesions |
1 | Mild focal encephalitis with infiltration of scattered heterophils and macrophages in neuropil. Minimal tissue destruction |
2 | Moderately dense infiltrates of heterophils and macrophages with associated tissue destruction |
3 | Severe focal or multifocal encephalitis with dense infiltrates of heterophils and macrophages and associated severe destruction of tissue |
|