Table 1: Recommended DOTS treatment regimen for each category of tuberculosis in Ghana.

Patient categoryDefinitionInitial phase treatmentContinuation phase treatment
Daily (28 doses/month)Daily (28 doses/month)

All new cases
I(i) New smear-positive2 (HRZE)2 = 56 doses of HRZE4 (HR) = 112 doses of HR
(ii) New smear-negative PTB
(iii) Concomitant HIV disease
(iv) Extrapulmonary TB

Previously treated sputum smear-positive PTB
II(i) Relapse2 (HRZE)S + 1 (HRZE) = 84 doses of HRZE + 56 doses of S5 (HRE) = 140 doses of HRE
(ii) Treatment after interruption
(iii) Treatment failure

III3Children below 12 years2 (HRZ) = 56 doses of HRZ4 (HR) = 112 doses of HR

Table 1 is adopted from the National Tuberculosis Programme (NTP) Training Manual, 2012. 1Direct observation of treatment intake is required and always in regimens including rifampicin. 2Streptomycin may be used instead of ethambutol. In meningitis, ethambutol should be replaced by streptomycin. 3In children with meningitis, add streptomycin in the initial phase. Category I: new clients; category II: previously treated clients; category III: children < 12 years. TB drugs and codes: H: isoniazid; R: rifampicin; Z: pyrazinamide; S: streptomycin; E: ethambutol. Codes for Fixed Drug Combinations (FDC): (HR): isoniazid + rifampicin; (HRZ): isoniazid + rifampicin + pyrazinamide; (HRZE): isoniazid + rifampicin + pyrazinamide + ethambutol. The administration of these drugs has been expansively explained in the 2012 edition of the NTP Training Manual.