The Scientific World Journal

The Scientific World Journal / 2001 / Article
Special Issue

TSW Collections: 4th International Meeting of the Calcitonin Gene-Related Peptide, 2001

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Volume 1 |Article ID 402790 | https://doi.org/10.1100/tsw.2001.405

W. Born, K. Leuthauser, R. Gujer, R. Muff, J.A. Fischer, "Structural Determinants in the Calcitonin Receptor-Like Receptor (Crlr) Important for Cgrp and Adrenomedullin (Am) Receptor Function of Crlr/Receptor-Activity-Modifying Protein (Ramp) 1 and Crlr/Ramp2 Heterodimers", The Scientific World Journal, vol. 1, Article ID 402790, 1 page, 2001. https://doi.org/10.1100/tsw.2001.405

Structural Determinants in the Calcitonin Receptor-Like Receptor (Crlr) Important for Cgrp and Adrenomedullin (Am) Receptor Function of Crlr/Receptor-Activity-Modifying Protein (Ramp) 1 and Crlr/Ramp2 Heterodimers

Abstract

Cell surface protein cross-linking, coimmmunoprecipitation, and confocal microscopy identified CRLR/RAMP1-, CRLR/RAMP2-, and calcitonin receptor isotype 2 (CTR2)/RAMP1 heterodimers as CGRP-, AM-, and CGRP/amylin receptors, linked to cAMP production. Along these lines, effects of structural alterations in the N-terminal extracellular domain of the human CRLR on cell surface expression as well as the association with RAMP and CGRP or AM have been investigated.


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