The Scientific World Journal

The Scientific World Journal / 2001 / Article
Special Issue

TSW Collections: 4th International Meeting of the Calcitonin Gene-Related Peptide, 2001

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Extended Abstract | Open Access

Volume 1 |Article ID 892524 | 1 page |

Study of Cgrp-Receptors in Human Isolated Middle Meningeal Arteries Using Bibn4096Bs, Compound 1, and HαCgrp(8-37)


Calcitonin, CGRP, adrenomedullin, and amylin require both CRLR (calcitonin-gene receptor like receptor) and receptor activity modifying proteins (RAMP1, RAMP2, and RAMP3) in different combinations for expression of selective, functional receptors[1]. We investigated whether the antagonists BIBN4096BS[2], Compound 1 (WO98/11128, [3]), and CGRP(8-37) are functionally selective for CGRP receptors in human middle meningeal arteries (HMMA).

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