TSW Collections: 4th International Meeting of the Calcitonin Gene-Related Peptide, 2001View this Special Issue
Extended Abstract | Open Access
Study of Cgrp-Receptors in Human Isolated Middle Meningeal Arteries Using Bibn4096Bs, Compound 1, and HαCgrp(8-37)
Calcitonin, CGRP, adrenomedullin, and amylin require both CRLR (calcitonin-gene receptor like receptor) and receptor activity modifying proteins (RAMP1, RAMP2, and RAMP3) in different combinations for expression of selective, functional receptors. We investigated whether the antagonists BIBN4096BS, Compound 1 (WO98/11128, ), and CGRP(8-37) are functionally selective for CGRP receptors in human middle meningeal arteries (HMMA).