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TheScientificWorldJOURNAL
Volume 2 (2002), Pages 1816-1822
http://dx.doi.org/10.1100/tsw.2002.861
Short Communication

The Accumulation of Deficits with Age and Possible Invariants of Aging

Department of Medicine, Dalhousie University, 5955 Veterans’ Memorial Lane, Halifax, Nova Scotia, B3H 2E1, Canada

Received 22 January 2002; Revised 20 May 2002; Accepted 20 May 2002

Copyright © 2002 Arnold B. Mitnitski et al.

Citations to this Article [53 citations]

The following is the list of published articles that have cited the current article.

  • K Rockwood, Aj Mogilner, Ab Mitnitski, and C MacKnight, “The mortality rate as a function of accumulated deficits in a frailty index,” Mechanisms Of Ageing And Development, vol. 123, no. 11, pp. 1457–1460, 2002. View at Publisher · View at Google Scholar
  • Arnold Mitnitski, Kenneth Rockwood, and Alexander Mogilner, “Changes with age in the distribution of a frailty index,” Mechanisms of Ageing and Development, vol. 125, no. 7, pp. 517–519, 2004. View at Publisher · View at Google Scholar
  • K Rockwood, Ab Mitnitski, and Xw Song, “The estimation of relative fitness and frailty in community-dwelling older adults using self-report data,” Journals Of Gerontology Series A-Biological Sciences And Medical Sciences, vol. 59, no. 6, pp. 627–632, 2004. View at Publisher · View at Google Scholar
  • K Rockwood, H Bergman, C Wolfson, Db Hogan, Se Howlett, I McDowell, Bl Beattie, C MacKnight, and R Hebert, “Prevalence, attributes, and outcomes of fitness and frailty in community-dwelling older adults: Report from the Canadian Study of Health and Aging,” Journals Of Gerontology Series A-Biological Sciences And Medical Sciences, vol. 59, no. 12, pp. 1310–1317, 2004. View at Publisher · View at Google Scholar
  • Kenneth Rockwood, Xiaowei Song, Howard Bergman, Ian McDowell, Chris MacKnight, David B. Hogan, and Arnold Mitnitski, “A global clinical measure of fitness and frailty in elderly people,” Cmaj, vol. 173, no. 5, pp. 489–495, 2005. View at Publisher · View at Google Scholar
  • Melissa K. Andrew, “Social capital, health, and care home residence among older adults: a secondary analysis of the Health Survey for England 2000,” European Journal of Ageing, vol. 2, no. 2, pp. 137–148, 2005. View at Publisher · View at Google Scholar
  • Esko Leskinen, Tiina-Mari Lyyra, and Eino Heikkinen, “A cohort study found good respiratory, sensory and motor functions decreased mortality risk in older people,” Journal of Clinical Epidemiology, vol. 58, no. 5, pp. 509–516, 2005. View at Publisher · View at Google Scholar
  • Xiaowei Song, Arnold Mitnitski, and Kenneth Rockwood, “Index Variables for Studying Outcomes in Vascular Cognitive Impairment,” Neuroepidemiology, vol. 25, no. 4, pp. 196–204, 2005. View at Publisher · View at Google Scholar
  • Alexander Kulminski, Anatoli Yashin, Igor Akushevich, Konstantin Arbeev, Kenneth Manton, Svetlana Ukraintseva, and Kenneth Land, “Accumulation of health disorders as a systemic measure of aging: Findings from the NLTCS data,” Mechanisms of Ageing and Development, vol. 127, no. 11, pp. 840–848, 2006. View at Publisher · View at Google Scholar
  • H. Bergman, L. Ferrucci, J. Guralnik, D. B. Hogan, S. Hummel, S. Karunananthan, and C. Wolfson, “Frailty: An Emerging Research and Clinical Paradigm--Issues and Controversies,” The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, vol. 62, no. 7, pp. 731–737, 2007. View at Publisher · View at Google Scholar
  • Y. Rolland, G. Abellan Kan, A. Benetos, H. Blain, M. Bonnefoy, P. Chassagne, C. Jeandel, M. Laroche, F. Nourhashemi, P. Orcel, F. Piette, C. Ribot, P. Ritz, C. Roux, J. Taillandier, F. Tremollieres, G. Weryha, and B. Vellas, “Frailty, osteoporosis and hip fracture: Causes, consequences and therapeutic perspectives,” The Journal of Nutrition Health and Aging, vol. 12, no. 5, pp. a319–a330, 2008. View at Publisher · View at Google Scholar
  • Eugene M.G. Milne, “The natural distribution of survival,” Journal of Theoretical Biology, vol. 255, no. 2, pp. 223–236, 2008. View at Publisher · View at Google Scholar
  • Y. Rolland, G. Abellan van Kan, A. Bénétos, H. Blain, M. Bonnefoy, P. Chassagne, C. Jeandel, M. Laroche, F. Nourhashémi, P. Orcel, F. Piette, C. Ribot, P. Ritz, C. Roux, J. Taillandier, F. Trémollières, G. Weryha, and B. Vellas, “Fragilité, ostéoporose et fracture du col du fémur: causes, conséquences et perspectives thérapeutiques,” Les cahiers de l'année gérontologique, vol. 1, no. 3, pp. 172–187, 2009. View at Publisher · View at Google Scholar
  • Steve A.R. Webb, Carol George, David Pilcher, Graeme K. Hart, Sean M. Bagshaw, Anthony Delaney, and Rinaldo Bellomo, “Very old patients admitted to intensive care in Australia and New Zealand: A multi-centre cohort analysis,” Critical Care, vol. 13, no. 2, 2009. View at Publisher · View at Google Scholar
  • José Juan García-Gonzlez, Carmen García-Pẽa, Francisco Franco-Marina, and Luis Miguel Gutiérrez-Robledo, “A frailty index to predict the mortality risk in a population of senior mexican adults,” BMC Geriatrics, vol. 9, no. 1, 2009. View at Publisher · View at Google Scholar
  • Michael R. H. Rockwood, Arnold Mitnitski, and Kenneth Rockwood, “Physiological redundancy in older adults in relation to the change with age in the slope of a frailty index,” Journal of the American Geriatrics Society, vol. 58, no. 2, pp. 318–323, 2010. View at Publisher · View at Google Scholar
  • Serena Dato, Alberto Montesanto, Vincenzo Lagani, Bernard Jeune, Kaare Christensen, and Giuseppe Passarino, “Frailty phenotypes in the elderly based on cluster analysis: a longitudinal study of two Danish cohorts. Evidence for a genetic influence on frailty,” Age, vol. 34, no. 3, pp. 571–582, 2011. View at Publisher · View at Google Scholar
  • Berstein, “Interrelations between cancer of hormone-dependent tissues and other major noncommunicable diseases: The age-specific aspect,” Advances in Gerontology, vol. 1, no. 2, pp. 140–151, 2011. View at Publisher · View at Google Scholar
  • Prashant Nasa, Deven Juneja, Omender Singh, Rohit Dang, and Vikas Arora, “Severe sepsis and its impact on outcome in elderly and very elderly patients admitted in intensive care unit,” Journal of Intensive Care Medicine, vol. 27, no. 3, pp. 179–183, 2012. View at Publisher · View at Google Scholar
  • R. Romero-Ortuno, and R. A. Kenny, “The frailty index in Europeans: association with age and mortality,” Age and Ageing, vol. 41, no. 5, pp. 684–689, 2012. View at Publisher · View at Google Scholar
  • Vittorio Pavoni, Lara Gianesello, Laura Paparella, Laura Tadini Buoninsegni, Emanuele Mori, and Gabriele Gori, “Outcome and quality of life of elderly critically ill patients: An Italian prospective observational study,” Archives of Gerontology and Geriatrics, vol. 54, no. 2, pp. e193–e198, 2012. View at Publisher · View at Google Scholar
  • Evelien Pijpers, Isabel Ferreira, Coen D.A. Stehouwer, and Arie C. Nieuwenhuijzen Kruseman, “The frailty dilemma. Review of the predictive accuracy of major frailty scores,” European Journal of Internal Medicine, vol. 23, no. 2, pp. 118–123, 2012. View at Publisher · View at Google Scholar
  • Adnan Tas, Tamer Tetiker, Yavuz Beyazit, Hacer Celik, and Yusuf Yesil, “Thyroid hormone levels as a predictor of mortality in intensive care patients: A comparative prospective study,” Wiener klinische Wochenschrift, vol. 124, no. 5-6, pp. 154–159, 2012. View at Publisher · View at Google Scholar
  • Philip D. St John, Suzanne L. Tyas, and Patrick R. Montgomery, “Life satisfaction and frailty in community-based older adults: cross-sectional and prospective analyses,” International Psychogeriatrics, vol. 25, no. 10, pp. 1709–1716, 2013. View at Publisher · View at Google Scholar
  • Josje D. Schoufour, Arnold Mitnitski, Kenneth Rockwood, Heleen M. Evenhuis, and Michael A. Echteld, “Development of a frailty index for older people with intellectual disabilities: Results from the HA-ID study,” Research in Developmental Disabilities, vol. 34, no. 5, pp. 1541–1555, 2013. View at Publisher · View at Google Scholar
  • Malcolm Elliott, Linda Worrall-Carter, and Karen Page, “Intensive care readmission: A contemporary review of the literature,” Intensive and Critical Care Nursing, 2013. View at Publisher · View at Google Scholar
  • Benissa E. Salem, Adeline Nyamathi, Lynn Brecht, Linda R. Phillips, Janet Mentes, Catherine Sarkisian, and Judith A. Stein, “Constructing and Identifying Predictors of Frailty among Homeless Adults-A Latent Variable Structural Equations Model Approach,” Archives of Gerontology and Geriatrics, 2013. View at Publisher · View at Google Scholar
  • Adeline M. Nyamathi, Mary-Lynn Brecht, Linda R. Phillips, Janet C. Mentes, Catherine Sarkisian, and Barbara Leake, “Correlates of Frailty Among Homeless Adults,” Western Journal of Nursing Research, vol. 35, no. 9, pp. 1128–1152, 2013. View at Publisher · View at Google Scholar
  • M. E. Salive, “Multimorbidity in Older Adults,” Epidemiologic Reviews, vol. 35, no. 1, pp. 75–83, 2013. View at Publisher · View at Google Scholar
  • Carl-Johan Dalgaard, and Holger Strulik, “Optimal Aging And Death: Understanding The Preston Curve,” Journal of the European Economic Association, 2014. View at Publisher · View at Google Scholar
  • C. Handforth, A. Clegg, C. Young, S. Simpkins, M. T. Seymour, P. J. Selby, and J. Young, “The prevalence and outcomes of frailty in older cancer patients: a systematic review,” Annals of Oncology, 2014. View at Publisher · View at Google Scholar
  • Cristina Buigues, Celia Padilla-Sánchez, Julio Fernández Garrido, Rut Navarro Martínez, Vicente Ruiz Ros, and Omar Cauli, “The relationship between depression and frailty syndrome: a systematic review,” Aging & Mental Health, pp. 1–11, 2014. View at Publisher · View at Google Scholar
  • Holger Strulik, “A Closed-Form Solution For The Health Capital Model,” Journal of Demographic Economics, vol. 81, no. 03, pp. 301–316, 2015. View at Publisher · View at Google Scholar
  • Holger Strulik, “Frailty, Mortality, and the Demand for Medical Care,” The Journal of the Economics of Ageing, 2015. View at Publisher · View at Google Scholar
  • Lenneke E. M. Haas, Attila Karakus, Rebecca Holman, Sezgin Cihangir, Auke C. Reidinga, and Nicolette F. de Keizer, “Trends in hospital and intensive care admissions in the Netherlands attributable to the very elderly in an ageing population,” Critical Care, vol. 19, no. 1, 2015. View at Publisher · View at Google Scholar
  • Philip D. St. John, and Patrick R. Montgomery, “An Early Risk Index: The Original Frailty Measure?,” Journal of the American Geriatrics Society, vol. 63, no. 5, pp. 1030–1031, 2015. View at Publisher · View at Google Scholar
  • Karen Grimmer, Debra Kay, Jan Foot, and Khushnum Pastakia, “Consumer views about aging-in-place,” Clinical Interventions In Aging, vol. 10, pp. 1803–1811, 2015. View at Publisher · View at Google Scholar
  • Swadhin Taneja, Arnold B. Mitnitski, Kenneth Rockwood, and Andrew D. Rutenberg, “Dynamical network model for age-related health deficits and mortality,” Physical Review E, vol. 93, no. 2, 2016. View at Publisher · View at Google Scholar
  • E.H. Gordon, N.M. Peel, M. Samanta, O. Theou, S.E. Howlett, and R.E. Hubbard, “Sex differences in frailty: A systematic review and meta-analysis,” Experimental Gerontology, 2016. View at Publisher · View at Google Scholar
  • Holger Strulik, and Katharina Werner, “50 is the new 30—long-run trends of schooling and retirement explained by human aging,” Journal of Economic Growth, 2016. View at Publisher · View at Google Scholar
  • Karen Grimmer, Kate Kennedy, Steven Milanese, Kay Price, and Debra Kay, “The Australian 75+ Health Assessment: could it detect early functional decline better?,” Australian Health Review, vol. 40, no. 1, pp. 69, 2016. View at Publisher · View at Google Scholar
  • Joanna M. Blodgett, Olga Theou, Susan E. Howlett, and Kenneth Rockwood, “A frailty index from common clinical and laboratory tests predicts increased risk of death across the life course,” GeroScience, 2017. View at Publisher · View at Google Scholar
  • Mark Kelly, “Health capital accumulation, health insurance, and aggregate outcomes: A neoclassical approach,” Journal of Macroeconomics, vol. 52, pp. 1–22, 2017. View at Publisher · View at Google Scholar
  • Holger Strulik, “The Health Hump,” Journal of Demographic Economics, vol. 83, no. 02, pp. 245–258, 2017. View at Publisher · View at Google Scholar
  • Johannes Schünemann, Holger Strulik, and Timo Trimborn, “Going from Bad to Worse: Adaptation to Poor Health Health Spending, Longevity, and the Value of Life,” Journal of Economic Behavior & Organization, 2017. View at Publisher · View at Google Scholar
  • Johannes Schünemann, Holger Strulik, and Timo Trimborn, “The Gender Gap in Mortality: How Much Is Explained by Behavior?,” Journal of Health Economics, 2017. View at Publisher · View at Google Scholar
  • Carl-Johan Dalgaard, and Holger Strulik, “The genesis of the golden age: Accounting for the rise in health and leisure,” Review of Economic Dynamics, vol. 24, pp. 132–151, 2017. View at Publisher · View at Google Scholar
  • A. V. Karnaukhov, E. V. Karnaukhova, L. A. Sergievich, N. A. Karnaukhova, E. V. Bogdanenko, I. A. Manokhina, and V. N. Karnaukhov, “The information theory of aging: The major factors that determine lifespan,” Biophysics, vol. 62, no. 5, pp. 829–835, 2017. View at Publisher · View at Google Scholar
  • Daniel Howdon, and Nigel Rice, “Health care expenditures, age, proximity to death and morbidity: Implications for an ageing population,” Journal of Health Economics, 2017. View at Publisher · View at Google Scholar
  • Holger Strulik, “The Return to Education in Terms of Wealth and Health,” The Journal of the Economics of Ageing, 2017. View at Publisher · View at Google Scholar
  • Marshall G. Miller, Nopporn Thangthaeng, and Barbara Shukitt-Hale, “A Clinically Relevant Frailty Index for Aging Rats,” The Journals of Gerontology: Series A, 2017. View at Publisher · View at Google Scholar
  • Ana Lucia Abeliansky, and Holger Strulik, “Hungry Children Age Faster,” Economics & Human Biology, 2018. View at Publisher · View at Google Scholar
  • Ana Lucia Abeliansky, and Holger Strulik, “How We Fall Apart: Similarities of Human Aging in 10 European Countries,” Demography, 2018. View at Publisher · View at Google Scholar